DSIP (Delta Sleep Inducing Peptide) – Product Information
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring substance. Clinical research has shown that it could increase total sleep time and sleep efficiency in people with insomnia. It has also exhibited the ability to reduce sleep latency and awakening after sleep onset.
It has also been found to improve the daytime performance of people with narcolepsy, a chronic neurological disorder in which people feel very sleepy throughout the day. Its effects have led to the assumption that DSIP might modulate sleep and wake cycles.
PureRawz sells DSIP for laboratory and research use only.
|Delta sleep-inducing peptide|
|Molar Mass||848.8 g/mol|
|IUPAC Name||DL-tryptophyl-DL-alanyl-glycyl-glycyl-DL-alpha-aspartyl-DL-alanyl-DL-seryl-glycyl-DL-glutamic acid|
What is DSIP?
Delta sleep-inducing peptide is a neuropeptide that was first detected in the rabbit brain in 1963. In 1977, the peptide was isolated from cerebral venous blood for the first time. Subsequent research has shown that DSIP is normally synthesized in the hypothalamus. [R]
Research has shown that DSIP is present in small amounts in the blood. Its levels vary throughout the day and are higher in the afternoons. This peptide has also been found in relatively high concentrations in human milk, with values ranging from 10 ng m/L to 30 ng m/L. [R]
Preclinical studies have shown that it can cross the blood-brain barrier. DSIP has also shown the ability to be readily absorbed by the gut without being denatured by enzymes. Furthermore, it has been established that it causes mild side effects and no withdrawal symptoms. [R]
In a clinical study, the administration of DSIP increased sleep duration and reduced sleep disturbance and latency in people with insomnia. Another study reported that this neuropeptide reduced sleep onset and increased sleep duration and efficiency in healthy adults. [R]
How Does DSIP Work?
Until now, various effects of DSIP have been reported, including:
Increases Delta-Wave Activity in the Brain
Delta sleep-inducing peptide got its current name because of its delta-wave (-sleep) increasing effect. This effect was first observed in rabbits and later reported in rats and mice. Delta waves are the slowest recorded brain waves. They are associated with the deepest levels of restorative, healing sleep. [R][R]
Increase Rapid-Eye-Movement Sleep
In a preclinical study involving cats, DSIP was reported to produce a more pronounced increase in rapid-eye-movement sleep than in delta sleep. REM sleep is a stage of sleep during which your eyes move around rapidly. It is associated with dreaming and memory consolidation. [R][R]
Increase Non-REM Sleep
In a pilot study investigating the sleep-inducing capacity of it in humans, this neuropeptide produced enhancements in non-REM as well as REM sleep. Researchers have proposed that abnormalities in NREM sleep may play a role in Alzheimer’s and Parkinson’s disease. [R][R][R]
Potentially Increases Slow-Wave Sleep
A preclinical study reported a significant increase in slow wave sleep (SWS) in cats following DSIP administration. SWS consists of stage three of NREM sleep and usually lasts between 70 and 90 minutes. Your body is at its most restful during this stage of sleep. [R]
Delta Sleep-Inducing Peptide Research
Following is a summary of the existing research on the Delta sleep-inducing peptide. The information given in this section is for educational purposes only. It doesn’t constitute medical advice. PureRawz sells DSIP for laboratory, educational, and scientific research purposes only.
Delta Sleep-Inducing Peptide and Insomnia
In a double-blind, placebo-controlled study, DSIP injections (30 nmol/kg body weight) increased sleep time by 22.5% compared with baseline. The treatment increased sleep efficiency by 26.8% and reduced sleep latency and awakening after sleep onset by 53% and 45%, respectively. [R]
Another study investigated the effects of DSIP treatment on chronic insomniac patients. It was reported that the DSIP group experienced higher sleep efficiency and shorter sleep latency compared to the placebo. One measure of subjectively estimated tiredness decreased within the DSIP group. [R]
A separate study reported that 6 out of 7 patients with severe insomnia had normalized sleep after receiving 10 DSIP injections within 14 days. [R]
Delta Sleep-Inducing Peptide and Normal Sleep
Three phase-1 studies investigated the effects of DSIP treatment on healthy volunteer subjects. Final results indicated that DSIP enhanced sleep, retained effects on sleep function up to 20 hours post-injection, and was well tolerated, with no side effects. [R][R][R]
A preclinical study showed DSIP increased some sleep patterns (i.e., SWS). DSIP was found to produce a significant increase in deep slow wave sleep (S2), while light slow wave sleep (S1) was significantly decreased. REM and NREM sleep cycles remained unaffected. [R]
Delta Sleep-Inducing Peptide and Schizophrenia
A clinical investigation compared cerebrospinal fluid levels of Delta sleep-inducing peptide in healthy volunteers and patients with schizophrenia. That is because DSIP neuropeptide has been shown to have direct effects on the central nervous system functioning in various mammals. [R]
Results from the study show that patients with schizophrenia had significantly lower CFC levels of DSIP than the healthy volunteers. [R]
Delta Sleep-Inducing Peptide and Major Depressive Disorder
The above clinical investigation also compared the CFL levels of DSIP in healthy volunteers and patients with major depressive disorder. Just as it was with schizophrenia, patients with MDD had significantly lower CSF levels of DSIP than healthy volunteers. [R]
Significantly, the levels of it in CSF tended to be inversely correlated to the sleep disturbance scores in depressed patients. [R]
Another study investigated the levels of plasma DSIP in suicidal patients with MDD. It reported significantly elevated DSIP levels in MDD patients. A significant correlation was also established between cortisol (aka the “stress hormone”) and DSIP levels in healthy controls. [R]
Delta Sleep-Inducing Peptide and Narcolepsy
Narcolepsy is a chronic neurological disorder characterized by daytime drowsiness and sudden bouts of sleep. People with narcolepsy can fall asleep anywhere, anytime, without clinical or laboratory signs.
A researcher investigated the effects of DSIP on a male narcoleptic. Repeated injections of this sleep-inducing peptide, either in the evening or in the morning, were associated with enhanced daytime activity. The frequency of sleep attacks was also reduced, and daytime performance increased. [R]
Delta Sleep-Inducing Peptide and Pain
In a clinical study, 6 out of 7 patients suffering from chronic pain syndromes responded well to DSIP therapy. The patients were feeling different types of discomfort. These included migraine headaches, vasomotor headaches, foot pain of psychogenic origin, and tinnitus. [R]
All the patients were required to report their pain perception on a visual analog scale. Except for one patient with migraine, all others reported reduced pain and improved mood. The changes (significantly reduced pain perception) persisted for up to 91 days. [R]
Delta Sleep-Inducing Peptide and Drug Abuse
According to a clinical study with 41 opiate addicts and 47 alcoholics, 97% of the opiate and 87% of the alcoholic patients were successfully treated with DSIP-injected IV. Significantly, the Delta sleep-inducing peptide treatment was considered superior to the usual withdrawal treatments. [R]
Delta Sleep-Inducing Peptide and Blood Pressure
A preclinical study investigated whether DSIP could regulate blood pressure. Final results indicated that Delta sleep-inducing peptide treatment decreased control rats’ heart rate and blood pressure level. However, it had no such effect on the already depressed level of blood pressure in the other group. [R]
DSIP and Somatostatin
Somatostatin is a protein that inhibits muscle growth. One preclinical study inhibited somatostatin release via a dopaminergic (related to dopamine) mechanism in muscle cells. [R]
Where to Buy Delta Sleep-Inducing Peptide Online?
PureRawz is the best place to buy the highest-quality Delta sleep-inducing peptide online.
In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. We sell liquid, powder, and capsule high-quality TUDA formulations. All the formulations are equally high-quality.
Delta sleep-inducing peptide has demonstrated the ability to influence sleep-wake cycles, increase sleep duration, and reduce sleep onset in insomniacs as well as healthy subjects. However, its effects aren’t limited to just sleep. It may also significantly reduce pain perception in patients with chronic pain of various origins.
PureRawz sells Delta sleep-inducing peptides for laboratory and research purposes only.