Enclomiphene Citrate
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Description
Enclomiphene Citrate – Product Information
Enclomiphene is an estrogen receptor (ER) modulator. It acts as an ER antagonist in humans, sheep, and rabbits and an ER agonist in rats. Enclomiphene inhibits the binding of 17beta-estradiol in isolated rabbit uterus. It decreases E2-induced inhibition of follicle-stimulating hormone (FSH) secretion in primary sheep pituitary cells in a concentration-dependent manner.
Enclomiphene (0.25 and 0.5 mg/animal) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats. Formulations containing enclomiphene have been used in the treatment of ovarian dysfunction.
Enclomiphene is being studied for its potential to increase serum total testosterone levels while maintaining sperm counts in the normal range in men with secondary hypogonadism.
| Enclomiphene | |
| CAS Number | 7599-79-3 |
| Molar Mass | 598.1g.mol-1 |
| Chemical Formula | C32H36ClNO8 |
| IUPAC Name | 2-[4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid |
How does Enclomiphene Citrate Work?
Enclomiphene citrate blocks estrogen from binding to receptors in the hypothalamus and increases gonadotropin release. [R]
In men, this results in increased testicular stimulation and testosterone production by increasing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. In women, this leads to ovulation. [R] [R]
Enclomiphene Citrate Research
Initial animal testing of enclomiphene citrate was conducted by Repros Therapeutics, this compound’s manufacturer. Later on, clinical phase II, phase IIB, and phase III studies have been carried out on this selective estrogen receptor modulator.
All these studies have shown that enclomiphene citrate effectively increases serum testosterone levels in hypogonadal men and maintains sperm counts. However, the impact of this compound on hypogonadal symptoms remains unknown. [R]
Enclomiphene Citrate and Hypogonadism
Hypogonadism is a condition in which the body doesn’t produce enough testosterone or sperm, or both. In adult males, symptoms of hypogonadism include decreased sex drive, decreased energy, and depression. Over time, hypogonadism can cause erectile dysfunction in men. [R]
In an animal study, baboons were given zuclomiphene, enclomiphene, or clomiphene for 12 days. Their serum hormone levels were measured at 0, 12, and 19 days. The study found that enclomiphene-treated baboons had a greater increase in testosterone than their clomiphene-treated counterparts. [R]
In a 2013 phase IIB human study, researchers noted a sustained increase in testosterone levels among the men in enclomiphene- and testosterone-treatment groups at three months of treatment. At follow-up, only enclomiphene treatment was associated with elevated sperm counts. [R]
A 2016 study found that oral enclomiphene nitrate raises testosterone and preserves sperm counts in obese hypogonadal men. Enclomiphene citrate treatment maintained sperm concentrations in the normal range. Topical testosterone wasn’t able to maintain sperm concentrations. [R]
Enclomiphene Citrate and Female Infertility
A randomized double-blind study was conducted to compare the effects of enclomiphene citrate (100 mg) with clomiphene citrate (100 mg) on women with unexplained infertility. It is to be noted that clomiphene citrate (Clomid) is an FDA-approved treatment for female infertility.
In terms of clinical pregnancy rate, no statistically significant difference was observed between the enclomiphene and clomiphene groups. The total number of mature follicles was significantly more in the enclomiphene group compared to clomiphene citrate. [R]
Pure Rawz offers Enclomiphene citrate for sale online for research use only.
Enclomiphene Citrate FAQs
Is Enclomiphene Citrate Legal?
Enclomiphene citrate is legal to buy and sell as a research chemical.
Pure Rawz sells enclomiphene citrate for research and laboratory use only. It should only be handled by qualified professionals and shouldn’t be used for veterinary or human use. This product isn’t in a sterile solution and shouldn’t be injected.
Is Enclomiphene the Same as Clomiphene?
Enclomiphene citrate is the trans-isomer of clomiphene citrate. While the latter consists of a mixture of isomers, enclomiphene citrate is a single isomer.
Does Enclomiphene Raise Testosterone?
One animal study and multiple clinical studies have shown that enclomiphene citrate may increase testosterone levels and maintain sperm concentrations in the normal range. It may carry out gonadotropin-dependent testosterone secretion.
Where to Buy Enclomiphene Citrate Online
PureRawz is the best place to buy Enclomiphene Citrate for sale.
In order to be the best research chemicals online supplier, we provide reference materials with every product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.
Summary
Enclomiphene citrate is a SERM that has demonstrated the potential ability to raise testosterone levels and maintain sperm concentrations in the normal range. It has been under review by the FDA since 2007 and is currently classified as a research chemical.
PureRawz is the best place to buy USA peptides (US-made peptides), SARMs, and other research chemicals online.
18 reviews for Enclomiphene Citrate
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Brad Olivier –
As a man in his 60s this works excellently for me and your team is always super helpful.
J Black –
This is a excellent for me in my late 40’s, boosted my strength and all round feeling healthier.
Chris Reps –
I know where to find my PCT from now on. You guys are great. I appreciate the friendly staff
Rick F Daniels –
Finally, everything works well. This product is very legit and I couldn’t wait to place a new order. By the way, thank you for great customer services.
Takahiro N –
I was actually being treated for secondary hypogonadism. This Enclomiphene worked like a charm.
Anthony –
I’ll buy it again. It really helps with recovering and in the end, with gains.
Timothy S. Chase –
A little expensive, but comparable to other places. Shipping was very fast to Canada, and free dropper was a nice added gift. Overall quite happy.
Roberto Wolf –
Best Enclomiphene source on the market!
Cicero Boyer –
Fast goods dispatch, fantastic product. I highly recommend, however I do find it quite expensive, especially in the UK when you get hammered by customs.
Anonymous –
I have been feeling great and absolutely destroying in the gym, very happy with the quality of this.
Jay Hudson –
This has really been helping boost my test levels, very happy with the quality of this.
Nick S –
I have been on this medication for low testosterone levels for almost a year and it works better than other brands. Amazing!
Mateo Villarreal –
Great results. Great service… Would definitely recommend!
Joel (verified owner) –
Quick shipping, no issues with product, is good stuff
Jamie Carey –
Absolutely love this product and thanks for the quick and efficient shipping, and awesome customer service.
Alex Maddison –
I highly recommend this Enclo. It really helped balance things out and keep most of the changes.
Anthony –
Always seems to amaze me!
Brody –
I noticed results in a week. At 40 I was tired, losing muscle and I couldn’t count on performing with aid. Well, I feel great, and everything works like I’m in my twenties.