GHRP-6

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Description

GHRP-6 – Product Information

GHRP-6 is a synthetic growth hormone secretagogue. Research has shown that it elicits a dose-related release of growth hormone (GH) in vivo and in vitro. GHRP-6 has also been found to enhance stage 2 sleep and cortisol release in healthy male subjects.

Results from a clinical trial show that GHRP-6 is more effective than GH-releasing hormone (GHRH) in increasing GH secretion in patients with hypothyroidism.

Furthermore, in an animal study, GHRP-6 treatment prevented the failure of cardiac function.

In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

PureRawz sells GHRP-6 for testing and laboratory experimentation.

GHRP-6 
CAS Number 87616-84-0
Molar Mass 873.032 g·mol−1
Chemical Formula C46H56N12O6
IUPAC Name L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide

What is GHRP-6?

Growth hormone-releasing peptide-6 is a synthetic hexapeptide that stimulates the secretion of GH. Just like GHRP-2, GHRP-6 is a ghrelin receptor agonist. Ghrelin is a hormone that regulates appetite, protects cardiovascular health, and stimulates GH secretion from the pituitary. [R]

GHRP-6 was the first-ever synthetic peptide that elicited a dose-related release in GH in vivo and in vitro. It was only after this peptide’s success that a heptapeptide, GHRP-1, and two other hexapeptides, GHRP-2 and Hexarelin, were synthesized and addressed by clinical studies. [R]

Various clinical studies have been conducted on GHRP-6. These studies have shown that GHRP-6 elicits GH release in healthy men as well as those with hypothyroidism. Furthermore, GHRP-6 has been shown to enhance second-wave sleep and cortisol release in healthy men. [R][R]

In animal and cell-based studies, GHRP-6 has been shown to enhance learning and memory, protect brain tissue during acute stroke, and expedite wound healing. The peptide has also been found to prevent failure of cardiac function and alleviate depression in animal models.

PureRawz only sells this research chemical for scientific research purposes.

 

How Does GHRP-6 Work?

GHRP-6 acts specifically on pituitary somatotrophs to stimulate GH release. This action of GHRP-6 seems to be mediated via the activation of phospholipase C and phosphoinositide breakdown, together with increased calcium (Ca2+) influx through voltage-dependent calcium channels. [R]

The peptide’s action isn’t limited to eliciting GH release, though. Recent evidence indicates that GHRP-6 may also stimulate the secretion of adrenocorticotrophic (ACTH) and prolactin hormones. This effect is generally attributed to the abovementioned central action of this peptide. [R]

GHRP-6 Research

Following is a summary of the existing clinical, animal, and cell-based research on GHRP-6.

The information given in this section is for educational purposes only. It shouldn’t be constituted medical advice. PureRawz sells research chemicals strictly for laboratory use.

GHRP-6 and Sleep

GHRP-6 treatment enhanced stage 2 sleep in a trial involving healthy men. After GHRP-6 administration, time spent in sleep stage 2 increased significantly. The amount of intermittent wakefulness also showed a trend toward decline, but the reduction wasn’t significant. [R]

Stage 2 sleep sees the body enter a more subdued state, including a drop in temperature, relaxed muscles, and slowed breathing. It lasts for about 10 to 25 minutes during the first sleep cycle and collectively accounts for about half the time an average person spends in their sleep.

GHRP-6 and Obesity

A pre-clinical study on mice investigated the effects of GHRP-6 administration on food intake, body weight, and blood glucose. Results from the study show that after 7 days of subcutaneous treatment, GHRP-6 decreased food intake in mice fed high-fat and standard diets. [R]

Furthermore, it was noted that GHRP-6 reduced body weight and blood glucose. The peptide also decreased insulin and leptin levels. These data suggest that ghrelin agonists could be especially beneficial for individuals with common obesity (high body fat).

GHRP-6 and Delayed Gastrointestinal Transit

Delayed gastrointestinal transit is a condition in which the stomach takes too long to empty. Its symptoms include loss of appetite, sensation of fullness in the body, and bloating. This condition might affect your nutrition, weight, and overall quality of life. [R]

In a study involving diabetic mice, GHRP-6 significantly improved the time the stomach took to get emptied. The peptide also improved intestinal transit or the time the food took to reach the stomach. Thus, GHRP-6 has therapeutic potential for diabetic patients with this condition. [R]

GHRP-6 and Stress Ulcers

Stress ulcers refer to the development of sores in the body and the stomach. These ulcers are caused by trauma, surgery, or sepsis. They damage the gastrointestinal lining and cause pain and a feeling of burning. The damage ranges from minor irritation to severe bleeding. [R]

Results obtained from a pre-clinical study show that GHRP-6 exerts a protective effect on gastric stress ulceration. These findings suggest a clinical application for the growth hormone-releasing peptide 6 in treating the stress-related or stress-caused gastric injury. [R]

GHRP-6 and Heart Health

In a mouse model of acute myocardial infarction, GHRP-6 prevented myocardial injury via a decrease in reactive oxygen species (ROS) and by preserving antioxidant defense systems. Thus, GHRP-6 exhibits antioxidant effects that may reduce myocardial ischemic damage. [R]

GHRP-6 also prevented ischemic-induced death in dogs with chronic dilated cardiomyopathy, a type of heart muscle disease that causes the heart chambers to stretch and become thin. Dilated cardiomyopathy is the most common type of heart disease. [R] [R]

GHRP-6 and Brain Health

A pre-clinical study assessed the effect of co-administration of human epidermal growth factor (EGF) and GHRP-6 on stroke therapy. It was found that the drugs improved survival and neurological outcome, and reduced stroke volume compared with vehicle treatment. [R]

Additionally, in another animal study, GH and GHRP-6 activated an intracellular signaling pathway that protects brain tissue. This coincided with GH and GHRP-6 modulating the expression of insulin-like growth factor 1 (IGF-1) in the central nervous system. [R]

GHRP-6 and Wound Healing

Evidence obtained by an animal study indicates that GHRP-6 enhances the healing process and improves the esthetic outcome of wounds. It was also found that the administration of this peptide did not hinder wound angiogenesis, nor did it promote blood vessel growth. [R]

GHRP-6 Safety

A 2014 study investigated the clinical safety of GHRP-6 in healthy volunteers. All the participants were between 18 and 35 years of age. Results from the study show that this peptide hormone’s administration was safe and tolerable under the conditions studied. [R]

Frequently Asked Questions

What are growth hormone-releasing peptides?

Growth hormone-releasing peptides (GHRPs) are synthetic peptides that stimulate GH release from the anterior pituitary gland. GHRPs are reportedly more effective than GH-releasing hormones in stimulating natural growth hormone release. Examples include GHRP-2, GHRP-6, and Hexarelin. [R][R]

What are the differences between GHRP-6 and GHRP-2?

GHRP-6 and GHRP-2 are synthetic agonists of ghrelin receptors. Both contain 6 amino acids in their chain and stimulate GH release in the body. However, they have slightly different amino acid sequences, half-lives (2.5 hours vs. 30 minutes), and molecular weights. [R]

Where to Buy GHRP-6?

PureRawz is the best place to buy GHRP-6 online.

In order to be the best supplier of research peptides, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers say about our products and great customer service.

Summary

GHRP-6 is a growth hormone secretagogue that has shown the ability to improve sleep, treat stress ulcers, and improve heart health in pre-clinical studies. The peptide hormone may also expedite wound healing and also possess neuroprotective effects.

Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.

14 reviews for GHRP-6

  1. micheal

    Got mine a week ago, and I am very happy with it so far. You guys never disappoint!

  2. Allen Rowans

    My test was a huge success! I saw significant results in my rat after 2 months of using it properly.

  3. Ethan

    Significant results. After using this for 3 weeks I can already see a change.

  4. Anonymous

    This product really works well, I’ve never had any issues with any products from you guys. Delivery is sometimes a bit long, but I’m always satisfied with the quality.

  5. Celvin Cook

    Great product, ordered more already! Shipping was quick this time.

  6. Alex Bowen

    Works like a charm!

  7. Jay Barrett

    I take it before gym and not only does it give me a super boost, it also helps me reduce belly fat.

  8. Torrey Raynor

    I have just begun taking this peptide. Amazing!

  9. Zayn

    Not only is my sleeping quality better, my overall performance as well.

  10. J Carter

    One of Purerawz’s best products!

  11. Randy

    I can definitely feel the difference.

  12. Allen Flynn

    I am seeing great results, visible muscle gain and I am losing some fat, very happy with the quality of this.

  13. Harry Rogers

    Great addition to my daily life!

  14. Brett Rangel

    My test subject told me this helps a lot with recovery and sleep whilst building mad muscle. He says he’s feeling much younger as well, so one big thumbs up from me!

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