What is GHRP-6?

Growth hormone releasing peptide-6 is a synthetic hexapeptide that stimulates the secretion of GH. Just like GHRP-2, GHRP-6 is a ghrelin receptor agonist. Ghrelin is a hormone that regulates appetite, protects cardiovascular health, and stimulates GH secretion from the pituitary. [R]

GHRP-6 was the first ever synthetic peptide that elicited a dose-related release in GH in vivo and in vitro. It was only after this peptide’s success that a heptapeptide, GHRP-1, and two other hexapeptides, GHRP-2 and Hexarelin, were synthesized and addressed by clinical studies. [R]

Various clinical studies have been conducted on GHRP-6. These studies have shown that GHRP-6 elicits GH release in normal men as well as those with hypothyroidism. Furthermore, GHRP-6 has been shown to enhance second-wave sleep and cortisol release in healthy men. [R][R]

In animal and cell-based studies, GHRP-6 has been shown to enhance learning and memory, protect brain tissue during acute stroke, and expedite wound healing. The peptide has also been found to prevent failure of cardiac function and alleviate depression in animal models.

Pure Rawz only sells this research chemical for scientific research purposes.

 

How does GHRP-6 Work?

GHRP-6 acts specifically on pituitary somatotrophs to stimulate GH release. This action of GHRP-6 seems to be mediated via activation of phospholipase C and phosphoinositide breakdown, together with increased calcium (Ca2+) influx through voltage-dependent calcium channels. [R]

The peptide’s action isn’t limited to eliciting GH release, though. Recent evidence indicates that GHRP-6 may also stimulate the secretion of adrenocorticotrophic (ACTH) and prolactin hormones. This effect is generally attributed to the abovementioned central action of this peptide. [R]

 

GHRP-6 Research

What follows is a summary of the existing clinical, animal, and cell-based research on GHRP-6. The information given in this section is for educational purposes only. It shouldn’t be constituted medical advice. Pure Rawz sells research chemicals strictly for laboratory use.

 

1) GHRP-6 and Sleep

GHRP-6 treatment enhanced stage 2 sleep in a trial involving healthy men. After GHRP-6 administration, time spent in sleep stage 2 increased significantly. The amount of intermittent wakefulness also showed a trend toward decline, but the reduction wasn’t significant. [R]

Stage 2 sleep sees the body enter a more subdued state, including a drop in temperature, relaxed muscles, and slowed breathing. It lasts for about 10 to 25 minutes during the first sleep cycle and collectively accounts for about half the time an average person spends in their sleep.

 

2) GHRP-6 and Obesity

A pre-clinical study investigated the effects of GHRP-6 administration on mice’s food intake, body weight, and blood glucose. Results from the study show that after 7 days of subcutaneous treatment, GHRP-6 decreased food intake in mice fed high-fat and standard diets. [R]

Furthermore, it was noted that GHRP-6 reduced body weight and blood glucose. The peptide also decreased insulin and leptin levels. These data suggest that ghrelin agonists could be especially beneficial for individuals with common obesity (high body fat).

 

3) GHRP-6 and Delayed Gastrointestinal Transit

Delayed gastrointestinal transit is a condition in which the stomach takes too long to empty. Its symptoms include loss of appetite, sensation of fullness in the body, and bloating. This condition might affect your nutrition, weight, and overall quality of life. [R]

In a study involving diabetic mice, GHRP-6 significantly improved the time the stomach took to get empty. The peptide also improved intestinal transit or the time the food took to reach the stomach. Thus, GHRP-6 has therapeutic potential for diabetic patients with this condition. [R]

 

4) GHRP-6 and Stress Ulcers

Stress ulcers refer to the development of sores in the body of the stomach. These ulcers are caused by trauma, surgery, or sepsis. They damage the gastrointestinal lining and cause pain and a feeling of burning. The damage ranges from minor irritation to severe bleeding. [R]

Results obtained from a pre-clinical study show that GHRP-6 exerts a protective effect on gastric stress ulceration. These findings suggest a clinical application for the growth hormone releasing peptide 6 in treating stress-related or stress-caused gastric injury. [R]

 

5) GHRP-6 and Heart Health

In a mouse model of acute myocardial infarction, GHRP-6 prevented myocardial injury via a decrease in reactive oxygen species (ROS) and by preserving antioxidant defense systems. Thus, GHRP6 exhibits antioxidant effects that may reduce myocardial ischemic damage. [R]

GHRP-6 also prevented ischemic-induced death in dogs with chronic dilated cardiomyopathy, a type of heart muscle disease that causes the heart chambers to stretch and become thin. Dilated cardiomyopathy is the most common type of heart disease. [R] [R]

 

6) GHRP-6 and Brain Health

A pre-clinical study assessed the effect of co-administration of human epidermal growth factor (EGF) and GHRP-6 on stroke therapy. It was found that the drugs improved survival and neurological outcome, and reduced stroke volume compared with vehicle treatment. [R]

Additionally, in another animal study, GH and GHRP-6 activated an intracellular signaling pathway that protects brain tissue. This coincided with GH and GHRP-6 modulating the expression of insulin-like growth factor 1 (IGF-1) in the central nervous system. [R]

 

7) GHRP-6 and Wound Healing

Evidence obtained by an animal study indicates that GHRP-6 enhances the healing process and improves the esthetic outcome of the wounds. It was also found that the administration of this peptide did not hinder wound angiogenesis, nor did it promote blood vessel growth. [R]

 

GHRP-6 Safety

A 2014 study investigated the clinical safety of GHRP-6 in healthy volunteers. All the participants were between 18 and 35 years of age. Results from the study show that this peptide hormone’s administration was safe and tolerable under the condition studied. [R]

 

Frequently Asked Questions

What are growth hormone-releasing peptides?

Growth hormone-releasing peptides (GHRPs) are synthetic peptides that stimulate GH release from the anterior pituitary gland. GHRPs are reportedly more effective than GH-releasing hormones in stimulating natural growth hormone release. Examples include GHRP-2, GHRP-6, and Hexarelin. [R][R]

 

What are the differences between GHRP-6 and GHRP-2?

GHRP-6 and GHRP-2 are synthetic agonists of ghrelin receptors. Both contain 6 amino acids in their chain and stimulate GH release in the body. But they have slightly different amino acid sequences, half-lives (2.5hrs vs. 30 minutes), and molecular weights. [R]

 

Does GHRP-6 enhance learning and memory formation?

No clinical evidence exists to support this hypothesis.

 

Where to Buy GHRP-6?

Pure Rawz is the best place to buy GHRP-6 online.

In order to be the best supplier of research peptides, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

 

Summary

GHRP-6 is a growth hormone secretagogue that has shown the ability to improve sleep, treat stress ulcers and improve heart health in pre-clinical studies. The peptide hormone may also expedite wound healing and also possesses neuroprotective effects.

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