Gonadorelin Acetate For Sale – Product Details

• Gonadorelin Acetate Spray is offered as 20mcg per spray and 2mg in total.

What is Gonadorelin Acetate?

Gonadorelin acetate is a synthetic form of the natural hormone gonadotropin-releasing hormone agonist (GnRH). [R] It is used by researchers as a potential diagnostic and therapeutic agent in the treatment of infertility, certain types of cancer, and other conditions related to hormonal imbalances.

Researchers show that when administered in pulses, gonadorelin acetate stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, which in turn may regulate the production of estrogen and testosterone by the ovaries and testes, respectively. [R]

How Does Gonadorelin Acetate Work?

Gonadorelin acetate works by potentially stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. LH and FSH play important roles in the regulation of the reproductive system, including the production of testosterone in males and the release of eggs from the ovaries in females. [R]

In males, LH stimulates the production of testosterone by the testes, while FSH plays a role in sperm production. In females, LH and FSH work together to stimulate the growth and maturation of ovarian follicles and the subsequent release of eggs during ovulation. By increasing the levels of LH and FSH, gonadorelin acetate can potentially help to stimulate these reproductive processes in individuals with certain medical conditions. [R]

Gonadorelin Acetate Research

Gonadorelin has been the subject of numerous clinical trials and has also been extensively studied in animal and cell-based research. These investigations have revealed various potential benefits of this synthetic peptide.

It should be noted that PureRawz provides Gonadorelin for research purposes only and not for human consumption.

Breast Cancer Prevention

Research has indicated that gonadorelin may have potential applications in breast cancer prevention, particularly for postmenopausal women. This is based on studies showing that GnRH analogs, such as gonadorelin, can reduce the risk of breast cancer by blocking estrogen receptors and decreasing circulating estrogen levels in this high-risk group. [R] This alludes to the potential of Gonadorelin in blocking excessive estrogen production which may lead to developing breast cancer.

Additionally, several studies have demonstrated the potential anti-tumor effects of gonadorelin, including its ability to reduce the proliferation, invasion, and migration of breast cancer cells, as well as promote apoptosis and inhibit metastasis. [R] [R] [R]

Male Infertility Studies

In 2016, a study reported a case of a man with hypogonadotropic hypogonadism (HH), azoospermia, and a history of anabolic steroid use, who underwent gonadotrophin therapy and successfully achieved conception. [R]

GnRH has shown potential in inducing spermatogenesis, resulting in the production of mature sperm in approximately 85% of patients. With an average treatment time of nine months, around 60% of couples were able to achieve pregnancy. [R]

Moreover, some men receiving GnRH treatment may potentially experience improvements in their sexual characteristics, such as an increase in testicular volume and growth of pubic hair. These changes serve as positive indicators of potential treatment effectiveness. [R]

Prostate Cancer Research

According to a study, localized prostate cancer cases can be potentially cured by at least 90% with combined androgen blockade (CAB) treatment. This treatment involves the combination of gonadorelin and newer, localized compounds that are already used to treat prostate cancer. [R]

Early diagnosis of prostate cancer is crucial for successful treatment with CAB therapy. The available diagnostic techniques have a 99% success rate in detecting prostate cancer at an early stage, making death from prostate cancer a rare occurrence with CAB treatment. This alludes to the future potential of Gonadorelin in treating prostate cancer.

Ovarian Cancer Research

A systematic review highlighted the potential role of GnRH in ovarian cancer with respect to its development, progression, and treatment. The study found that GnRH agonists may have an anti-proliferative effect that is dependent on the dose and duration of treatment in multiple cell lines from various cancer types.

Moreover, the study showed that GnRH agonists may have anti-tumor effects in ovarian cancer and that the expression of GnRH receptors could be used as a diagnostic tool to treat ovarian cancer metastases. [R]

Dementia Research

In 2005, a study found that LH and GnRH have neuronal receptors. LH can cross the blood-brain barrier, and the receptors for LH are most concentrated in the hippocampus, the brain region that is most susceptible to Alzheimer’s disease (AD). [R]

Another study showed that GnRH agonists may have therapeutic benefits for AD. The study followed two groups of patients for a twelve-year period after surgery, analyzing the development rate of select diagnoses of dementia, including AD. Compared to the control group, men hospitalized with prostate cancer who received GnRH therapy displayed potential protection against dementia. [R]

Bone Mineral Density Research

A study aimed to assess the effect of gonadorelin on bone mineral density in young men diagnosed with hypogonadotropic hypogonadism (HH). A total of 22 HH male patients and 20 healthy control subjects were recruited for the clinical trial.

Following six months of pulsatile gonadorelin therapy, a considerable increase in bone mineral density in the lumbar spine 2-4, femoral neck, and total hip was observed. Statistical analysis showed that the increase in bone mineral density in all of these regions was highly significant (P < 0.01, for all). [R]

FAQs

What is the difference between Gonadorelin and Gonadorelin Acetate?

Gonadorelin is the natural form of the hormone, while gonadorelin acetate is a synthetic form of gonadorelin. Gonadorelin acetate is created by modifying the amino acid sequence of natural gonadorelin, making it more stable and allowing for a longer half-life. This modification also increases the potency of gonadorelin acetate compared to natural gonadorelin. Gonadorelin acetate is typically used in medical treatments, while natural gonadorelin is not commonly used due to its short half-life and rapid degradation.

Is Gonadorelin a controlled substance?

Gonadorelin is not considered a controlled substance in most countries. However, it is regulated by the US Food and Drug Administration (FDA) and other regulatory agencies to ensure its safety and effectiveness.

Purerawz sells Gonadorelin Acetate for research purposes only.

What is the link between Gonadorelin and Growth Hormone Releasing Factor?

Gonadorelin and growth hormone-releasing factor (GRF) are both peptides that play potentially important roles in the endocrine system. Gonadorelin is a gonadotropin-releasing hormone that may stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, while GRF is a peptide hormone that stimulates the release of growth hormone (GH) from the pituitary gland.

There is a link between gonadorelin and GRF, as both hormones share a common precursor molecule known as progonadoliberin or pro-GnRH. Pro-GnRH is processed in different ways to form either gonadorelin or GRF, depending on the specific enzymes and receptors present in the target tissues. [R]

Additionally, it has been shown that gonadorelin can indirectly stimulate the release of GH by increasing the secretion of LH and subsequently testosterone, which in turn stimulates the release of GH from the pituitary gland. However, this effect is not as strong as the direct stimulation of GH release by GRF. Overall, the relationship between gonadorelin and GRF is complex and involves multiple pathways and interactions within the endocrine system. [R]

Where to Buy Gonadorelin Acetate Online?

Pure Rawz is the best place to buy Gonadorelin Acetate for sale.

In order to be the best supplier of tissue-selective research compounds, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

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