Gonadorelin Acetate Nasal Spray

Description

Overview of Gonadorelin Acetate

Gonadorelin Acetate is a synthetic analog of gonadotropin-releasing hormone (GnRH), which is a naturally occurring decapeptide normally produced by the hypothalamus. In biological systems, GnRH plays a central role in regulating reproductive hormone signaling. It interacts with the pituitary gland and triggers the release of two key hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are involved in reproductive hormone regulation and related physiological processes.

Gonadorelin acetate is studied for its role in the hypothalamic-pituitary-gonadal (HPG) axis and hormone signaling pathways in research models. It can be beneficial for investigating endocrine feedback mechanisms, reproductive hormone regulation, and GnRH-related biological activity in laboratory models.

Note: At PureRawz, Gonadorelin Acetate comes as a nasal spray. 20 mcg per spray (2 mg per bottle).

Chemical Properties of Gonadorelin Acetate

Property	Information
CAS Number	34973-08-5
Molecular Formula	C57H79N17O15
Molecular Mass	1242.3 g/mol
Synonyms	Gonadorelin acetate, ABBOTT-41070, GONAbreed, 2RG1XQ1NYJ
IUPAC Name	acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Storage	2-8°C (36-46°F)

How Does Gonadorelin Acetate Work?

Gonadorelin acetate functions as a synthetic analog of GnRH. It interacts with GnRH receptors located on the anterior pituitary gland. This interaction stimulates the release of two key gonadotropins, LH and FSH, in research models. These hormones subsequently influence gonadal activity and regulate the production of reproductive hormones such as testosterone and estrogen.

Because of this upstream signaling role, gonadorelin acetate is used in research to investigate hormonal signaling pathways and pituitary responses. It is also studied to better understand regulatory mechanisms within the hypothalamic-pituitary-gonadal (HPG) axis.

Research Findings on Gonadorelin Acetate

Gonadorelin Acetate has been studied in scientific and clinical research.Here are some areas where it is often used in research:

In a controlled aquatic research model, gonadorelin administration altered endocrine profiles by increasing circulating sex steroids such as estradiol, progesterone, and testosterone. It also promoted final oocyte maturation and ovulation compared with untreated research models. These findings shows gonadorelin's ability to modulate gonadotropin‑driven reproductive processes in vertebrate endocrine research.

In a mammalian research model, administration of gonadorelin at specific doses induced ovulation of persistent ovarian follicles. It also initiated a new follicular wave, demonstrating a dose-dependent effect on follicular dynamics and pituitary-gonadal signaling pathways.

Note: Gonadorelin was previously approved by the FDA for certain diagnostic and clinical applications. However, no actively marketed FDA-approved gonadorelin products are currently available. This compound is now supplied by PureRwaz for research purposes only.

Where to Buy Gonadorelin Acetate Nasal Spray?

PureRawz provides high-purity Gonadorelin Acetate Nasal Spray for laboratory and research applications. The compound is  prepared to ensure consistent performance in experimental studies of hormone signaling and pituitary-gonadal regulation.

All the products undergoes rigorous quality control and is accompanied by an independent Certificate of Analysis (COA). This verification confirms the compound's identity, purity, and overall quality.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.

Reference Links

PubChem. (2026). Gonadorelin Acetate. Nih.gov; PubChem.https://pubchem.ncbi.nlm.nih.gov/compound/11980076

Oliveira, R. G. de S., de Morais, I. S., Paixao, R. V., Bandeira, I. C., Duncan, W. L. P., & O'Sullivan, F. L. de A. (2025). Effects of gonadorelin on gonadotropin expression, plasma sex steroid concentrations and ovarian follicle dynamics in mature tambaqui (Colossoma macropomum). Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 279, 111126. https://doi.org/10.1016/j.cbpb.2025.111126

Pereira, R. G., Pires, O. S., Hoefle, C. A., Fritzen, A., Fiordalisi, G., Ferst, J. G., de Oliveira, F. C., Vieira, A. D., Mondadori, R. G., Maggi, G., Rovani, M. T., Gasperin, B. G., Goncalves, P. B., & Ferreira, R. (2024). GnRH analogs induce a LH peak and increase pregnancy per timed-AI in ewes. Theriogenology, 215, 132-137.https://doi.org/10.1016/j.theriogenology.2023.12.003