Indole 3 Carbinol


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Indole 3 Carbinol – Product Information

Indole-3-carbinol, a sulfur-containing compound, is synthesized from glucobrassicin, which is abundantly present in cruciferous vegetables (cabbage, broccoli, cauliflower, and more). This transformation occurs when these vegetables are sliced, masticated, or exposed to heat. Indole-3-carbinol can also be artificially generated.

Indole-3-carbinol is often employed for various purposes, including the promotion of proper detoxification, counteracting free radicals, and potentially aiding in cancer prevention. It is also sometimes used in the management of conditions like systemic lupus erythematosus (SLE). However, it’s crucial to note that there’s a lack of robust scientific evidence supporting these purported benefits.

Indole 3 Carbinol
CAS Number 700-06-1
Molar Mass 147,18 g/mol
Chemical Formula C9H9NO
IUPAC Name (1H-Indol-3-yl)methanol

What is Indole 3 Carbinol?

Indole-3-carbinol (I3C), a sulfur-containing compound found in foods like cabbage, broccoli, cauliflower, and other cruciferous vegetables, plays a significant role in promoting proper detoxification and supporting cellular health.

Derived from the breakdown of glucobrassicin, I3C undergoes a transformative process in the acidic stomach environment, yielding biologically active compounds such as 3,3′-diindolylmethane (DIM) and 5,11-dihydroindolo-[3,2-b]carbazole (ICZ). These molecules possess the ability to neutralize free radicals and influence biotransformation enzymes, crucial for metabolizing various biologically active substances, including hormones, drugs, carcinogens, and toxins.

I3C and DIM have been observed to modulate the expression and activity of these enzymes, potentially reducing the risk of hormone-dependent cancers. While their effects on breast cancer risk remain unclear, preclinical studies indicate their impact on multiple signaling pathways relevant to cancer cell behaviors.

Furthermore, preliminary trials suggest that I3C supplementation may hold promise in addressing conditions associated with human papillomavirus (HPV) infection, such as cervical/vulvar intraepithelial neoplasias and recurrent respiratory papillomatosis. However, the need for randomized controlled trials to establish the benefits of I3C supplementation in these contexts is evident.

Today Indole-3-Carbinol is available in different variants. Some come with 200 mg 60 veg capsules. Other sellers offer vegan products wherein tree nut ingredients are not present.

Possible Applications of Indole-3-Carbinol for Sale

Cancer Risk Reduction

Epidemiologic studies have linked a diet rich in cruciferous vegetables, the source of I3C, to lower cancer risk. Preclinical research indicates I3C’s potential in inhibiting various cancer types, including breast, and other reproductive organs. [R][R][R]

Multiple preclinical studies have demonstrated I3C’s anti-cancer effects in various cancer cell lines and animal models, suggesting its potential as a cancer-preventative agent. [R][R][R]

Antimicrobial and Anti-Inflammatory Properties

I3C exhibits antimicrobial and anti-inflammatory properties, which may contribute to its potential health benefits. [R][R]

Hormone Regulation

I3C has been shown to possess anti-estrogenic effects owing to its average rating value, suggesting a potential role in hormone-related conditions. Preclinical studies indicate I3C’s ability to modulate estrogen-related pathways. [R]

Angiogenesis Inhibition

I3C has demonstrated antiangiogenic properties, which could be valuable in limiting the formation of new blood vessels that feed tumors. Preclinical studies highlight I3C’s antiangiogenic effects. [R][R]

Enhanced Cancer Treatment

There’s preliminary evidence that I3C may enhance the effectiveness of certain cancer treatments, including chemotherapy drugs like tamoxifen, doxorubicin, and gemcitabine. Preliminary studies suggest I3C’s potential to enhance the effects of various cancer treatments. [R][R][R]

Precancerous Lesion Treatment

Clinical trials have shown promise in using I3C for treating precancerous conditions such as cervical dysplasia and vulvar intraepithelial neoplasia. Early-phase clinical trials have indicated the possible effectiveness of I3C against precancerous lesions. [R][R]

Hormone Metabolism Regulation

I3C and its active metabolite, DIM, may positively influence estrogen metabolism and hormone-binding globulin levels in premenopausal women, potentially reducing breast cancer risk. Randomized controlled trials (RCTs) involving DIM supplementation in breast cancer patients on tamoxifen suggest beneficial changes in estrogen metabolism. [R]

It’s important to note that while the preclinical and early clinical research shows promise, I3C’s effects in humans are not yet fully understood. Some studies suggest potential limitations and interactions with medications, and the optimal dosage for achieving its chemo-preventive benefits requires further investigation. [R]

Additionally, recent research indicates that the benefits of cruciferous vegetables like I3C may not necessarily require large quantities or high-dose supplements, suggesting that a balanced diet rich in these vegetables may be sufficient for health benefits. Further studies are needed to clarify these findings and establish I3C’s suitability as a chemo-preventive agent in participants. [R]

How Does Indole-3-Carbinol Work?

Indole-3-Carbinol (I3C) exerts its effects through a complex mechanism of action in the human body. Derived from the breakdown of a sulfur-containing compound called glucobrassicin found in cruciferous vegetables, I3C serves as a uniquely abundant source of health-protective benefits. Some of its actions are linked to epigenetic mechanisms that influence gene expression. Notably, I3C counters immune evasion by viruses like HPV16 by antagonizing key protein repression. It also acts as a histone deacetylase class I inhibitor, reducing proinflammatory cytokine production and dampening T-cell activation. In terms of hepatoprotective mechanisms, I3C modulates the immune response, inhibits proinflammatory cytokines and chemokines, and affects microRNAs associated with liver damage.

In cancer cells, I3C demonstrates diverse effects, inducing apoptosis at higher doses and inhibiting cell growth at lower doses. It regulates microRNAs, modulates estrogen receptors, and reduces the expression of enzymes like aromatase involved in estrogen synthesis. However, its role in carcinogenesis remains complex, and further human studies are needed to elucidate its precise impact.

Safety and Side Effects

Research findings suggest that indole-3-carbinol (I3C) is generally considered safe. However, in supplemental forms and higher doses, it may lead to digestive upset or gastrointestinal discomfort, particularly in sensitive subjects. Subjects who accidentally ingest I3C and feel certain side effects should seek to consult physician to address a particular medical condition. Test subjects who are taking medication are not advised to participate in any laboratory studies for I3C.

Frequently Asked Questions

How does I3C combat free radicals and promote detoxification?

I3C’s possible effect to combat free radicals is attributed to its antioxidant properties. It may neutralize these harmful molecules, potentially reducing oxidative stress in the body. I3C also promotes detoxification by influencing the activity of biotransformation enzymes, aiding in the metabolism and elimination of various toxins and potentially harmful substances.

How is I3C different from Flax Seed Lignan Extract?

I3C and Flax Seed Lignan Extract are distinct compounds. I3C is derived from cruciferous vegetables (cabbage broccoli cauliflower etc.) are uniquely abundant in a sulfur-containing compound called Indole 3 Carbinol (i3C) and is known for its role that supporting cellular health. Flax Seed Lignan Extract, on the other hand, is obtained from flaxseeds and is rich in lignans, which have their own set of health benefits.

Where Can You Buy Indole-3-Carbinol Online?

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This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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