Ligandrol (LGD-4033)
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Description
Ligandrol (LGD-4033) – Product Details
Ligandrol is a novel nonsteroidal oral selective androgen receptor modulator currently being investigated in research as a potential treatment for conditions relating to muscle dystrophy and osteoporosis.
Recent studies investigated the effects of LGD 4033 on muscle tissue in ovariectomized rats. A daily dose of LGD was administered and calculated according to the body weight of each individual rat at the onset of the study.
Results and changes were noted as soon as week 2, the control group having weighed significantly less than rats undergoing LGD treatment. This difference remained until the end of the study, irrespective of LGD treatments.
Additionally, the LGD treatments resulted in a higher number of capillaries in all muscles studied. Longer randomized trials and research could potentially evaluate its efficacy in improving physical function and health outcomes in select populations.
| LGD-4033 | |
| CAS Number | 1165910-22-4 |
| Molar Mass | 338.253 g·mol−1 |
| Chemical Formula | C14H12F6N2O |
| IUPAC Name | 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
How Does Ligandrol Work?
Ligandrol LGD-4033 works by binding androgen receptors (ARs) on a tissue-selective basis. It primarily targets ARs in the bone and muscle tissues, sparing the vital organs. This distinguishes LGD-4033 and other SARMs from testosterone and anabolic steroids, whose approach isn’t as targeted.
Ligand Pharmaceuticals developed LGD-4033 for increasing anabolic activity and the treatment of conditions such as muscle wasting and osteoporosis. This research compound was patented in 2009 and has attracted at least one clinical trial since.
Ligandrol Research
In phase 1 clinical trials, this SARM has been shown to increase lean muscle mass and strength, though it also suppressed total testosterone. Animal studies have highlighted its effects on bone density and strength.
Still, the available clinical data isn’t enough to verify its safety and efficacy. Long-term randomized clinical trials are needed.
Ligandrol and Muscle Mass
In the phase 1 clinical trial, 76 healthy men (ages 21-50 years) were randomized to placebo or 0.1, 0.3, or 1.0mg LGD-4033 daily for 21 days. Among other metrics, lean and fat mass and muscle strength were measured during and for 5 weeks after intervention.
LGD 4033 increased lean body mass in a dose-dependent manner. The gains in lean body mass were similar to those reported with Ostarine, although the treatment duration in the Ostarine trial was substantially longer (12 weeks). [R] [R]
Ligandrol and Muscle Strength
The phase 1 clinical trial also noted the effect of LGD-4033 on muscle strength. An increase in muscle strength averaging 68.3N was observed among the 1.0mg dose group, but this change was not significantly different from that in the placebo group.
This 3-week study, by demonstrating the safety and tolerability of LGD-4033 and significant gains in lean muscle mass and strength, paves the way for longer-term efficacy trials.
Ligandrol and Body Fat
The abovementioned trial also evaluated the impact of Ligandrol on body fat. While subjects who were administered 1mg/day LGD 4033 experienced more fat loss than those on 0.1mg and 0.3mg daily doses, on the whole, the fat mass did not change significantly.
More extensive research and randomized trials could potentially evaluate its efficacy in reducing body fat mass and increasing muscle growth in select populations.
Ligandrol and Bone Strength
In the 62nd Annual Meeting of the Gerontology Society of America in Atlanta, data from a preclinical study on LGD-4033 was featured. It was observed that Ligandrol increased bone density and bending strength (an indicator of resistance to fracture) in osteopenic female rats. [R]
Statistically significant improvements in bone mineral density were also observed after 12 weeks of administering LGD-4033 at doses as low as 0.03mg/kg/day (in cortical bone) and 0.3mg/kg/day (in cancellous bone).
Ligandrol FAQs
Is LGD-4033 Legal?
Ligandrol LGD-4033 is legal to buy and sell as a research compound. Like other SARMs, it can only be used for laboratory research use and isn’t approved for human consumption
Is LGD-4033 Safe?
In its only clinical trial conducted to date, LGD-4033 was well-tolerated.
There were no drug-related adverse events and the frequency of adverse events was similar between the placebo and any dose group. There were no clinically significant changes in liver enzymes, hematocrit, prostate-specific antigen, or electrocardiogram at any dose.
What is the half-life of LGD 4033?
Ligandrol LGD-4033 has a prolonged elimination half-life (24 – 36 hours) in research subjects.
Does Ligandrol suppress endogenous testosterone?
In a placebo-controlled study, there was a dose-dependent suppression of total testosterone and sex-hormone globulin levels from baseline to day 21. Upon discontinuation of LGD-4033, the hormone levels returned to baseline by day 56.
Does LGD-4033 cause liver toxicity?
In a placebo-controlled randomized clinical trial of LGD-4033 on healthy subjects, there were no clinically significant changes in liver enzymes.
Where to Buy LGD-4033 Online
PureRawz is the best place to buy LGD-4033 for sale.
In order to be the best SARMs supplier, we provide reference materials with every product we sell. Each of our SARMS comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.
Summary
Ligandrol LGD-4033 achieved significant dose-dependent gains in lean body mass and muscle strength in a short-duration placebo-controlled clinical trial. The compound was well tolerated by the subjects and there were no drug-related adverse events.
COA
45 reviews for Ligandrol (LGD-4033)
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Martin –
Probably my favorite SARM. Always get awesome results with ligandrol!
Paul Peterson –
My #1 PureRawz compound!
Bryan B (verified owner) –
Great Product, Noticeable strength in two weeks.
Morgan –
Never been more shredded!
Mike S –
Great quality with great results.
Anonymous –
The results are insane – lost some fat and gained awesome lean muscle.
Kyle Curran –
Super product and awesome customer service. Very easy ordering.
bigcajun-2784 –
Great quality. Slow steady increase in strength, muscle density, vascularity and weight. Absolutely recommend giving it a try
John S –
My first time using this product and so far I love the results. Thank you to my friend Mark who recommended this website. I owe you, buddy!
Jack Rosenman (verified owner) –
Will update with another review when I thoroughly test it out. I just got this today, and I ordered 3 days ago… I’m not sure how they can ship it from the UK to a small town in the US in 3 days, but damn was that quick. I did not expect that and will definitely order from them again. Not enough information testing it yet to give anything else to this review, but thought it was important.
Nigel Lawley –
Strength gains almost immediately.
Davis Robbins –
Always the best quality on the market.
Jeffrey Price –
I have been taking Ligandrol since the end of April, and so far it has helped me sustain energy and strength through my home workouts.
Alex Brooks –
I highly recommend this if you are looking to boost your athletic performance
David D. –
Got great strength gains, highly recommend this product!!
Rondon Cane –
I could not wait to get mine. The delivery time was well on point!
Mike Violet –
I got my products delivered in just five days!
I must say this is the best one for me 🙂
Bryan –
Awesome!
Flem93 –
The vial of oil(injectable form) was nice. The oil is thin and smooth with no pip. It worked very well for the research subject to put on size and muscle. Perfectly satisfied.
Sam –
Excellent quality. I read the description and got what I was hoping for. I highly recommend this if you are just starting out.
Kyle Simmers –
Without a doubt the best LGD I have tried.
Nelson White –
Gaining lean mass weekly – GREAT stuff this.
Anonymous –
You always have what I am looking for and you have the best customer service 🙂
Theron McLaughlin –
Best quality and brilliant results! Thank you for this wonderful product.
Lambert A –
Still affordable and convenient to place an order on your website.
Ben –
I have been blown away by the results, this product is perfect for me.
Joe L –
Very satisfied.
Devon –
Perfect for what i needed.
Gregorio –
Good quality Ligandrol.
Aaron P –
I wasn’t sure what to expect, having never taken this product before. I certainly feel more energized and leaner. I will continue using it!
Ernest Coffey –
This is top quality, strength gains are insane.
Jaxon Roth –
Very happy with the qualify of this, my muscle growth has been steady but at a very impressive rate.
JD Hegmann –
After observing results within the first several weeks, my test subject has genuinely transformed himself.
Jordan Mccarthy –
Definitely going to go for another cycle soon!
Damian Juarez –
Would recommend this to all the gym-rat vets! Good for decreasing muscle loss.
Andrew Brennan –
This has been great to use, my overall energy levels have increased and I am seeing a ton of muscle gains.
Benjamin Phillips –
It’s a great supplement, I would highly recommend it!
Dave C (verified owner) –
Had I read the reddit reviews beforehand I probably wouldnt have purchased from here because it get a bad rap from last year on. BUT not only is the COA from a legitimate source but the sides, headache and dry mouth, are on par with what this substance is known for. IMO this is just as good as the stuff I got from science.bio My “mice” gainz in strength and volume are noticable only 1 week out on 1.7 mg ED however tbh my shreds have gone done the toilet from the water weight and slight increase in appetite. It will be worth it at the end. Cheers guys and TY for the quality SARMs. I highly recommend LGD 4033 but dont be a SARM goblin, start your mice at 1mg and see how they acclimate first, but in my experience this is extremely well tolerated. I had chest pain on 80mg of TRT a week and with this stuff there is none of that. Gotta love the selectivity of this substance as it doesnt tax your organs like PEDs. Be safe and make gainz guys!
Absalom Minsk (verified owner) –
Shipping was super fast, my lab rat felt the effects within hours of first dose. Will be ordering again.
rickgaray –
Great product with solid strength results
Andrew Hanes –
Awesome! I’ll keep buying this great product because it’s so great.
Theo Holland –
The results are incredible: I reduced weight while gaining lean muscle. I highly recommend giving it a try for yourself.
Verified Buyer (verified owner) –
Increased strength 5%
Gary C. (verified owner) –
Verified Buyer (verified owner) –
good customer service. complained about batch quality and they sent a new one for free.