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Matrixyl – Product Information

Matrixyl, more commonly known as a cosmetic peptide, is a combination of fatty acids and proteins. Research has shown that it boosts the formation of collagen, a protein that gives your skin structure. In animal studies, Matrixyl has accelerated the wound healing process.

In a clinical study, treatment using this reduced fine lines in Caucasian female subjects. In vivo and in vitro studies have also demonstrated this peptide’s anti-wrinkle effects. Plus, it has been shown that Matrixyl stimulates collagen production in a concentration-dependent manner.

  • Matrixyl is offered as 10mg lyophilized powder.
  • In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

Pure Rawz sells Matrixyl for laboratory and research purposes only.

Matrixyl Peptide
CAS Number 214047-00-4
Molar Mass 802.05 g/mol
Chemical Formula C39H75N7O10
IUPAC Name palmitoyl-Lys-Thr-Thr-Lys-Ser-OH


What is Matrixyl?

It is a synthetic lipopeptide (amino acids + fatty acids). Its scientific name is Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3). Research has shown that it can successfully penetrate the skin’s upper (epidermis) and middle (dermis) layers. [R]

It was initially launched by Sederma Inc. in France in 2000. Early studies on this anti-aging peptide indicated its ability to penetrate the two upper layers of skin. In vivo, studies on this reported that it can enhance the secretion of collagen I by fibroblasts. [R][R]

A trial involving 94 healthy Caucasian females with facial wrinkles investigated the clinical outcome of this peptide. Results indicated that Matrixyl treatment reduced the length of fine lines. It also improved skin texture, age spots, and dark circles under the eyes. [R]

In addition to stimulating collagen production and reducing fine lines, it has been shown to increase hyaluronic acid synthase-1 expression in vitro. Hyaluronic acid is a substance produced in your body. It helps keep your connective tissues well-lubricated. [R][R]


How does Matrixyl Work?

Although its precise working mechanism remains unknown, it has been shown to:

  • Enhance collagen production by fibroblasts [R]
  • Up-regulate hyaluronic acid expression [R]
  • Increase pro-collagen (the precursor of collagen) secretion [R]


Matrixyl Research

Following is a summary of the existing preclinical and clinical studies on Matrixyl. The information presented in this section is for educational purposes only and doesn’t constitute medical advice. Speak to your doctor to know more about your skin type and this lipoprotein.

Matrixyl and Fine Lines/Wrinkles

In a double-blind, placebo-controlled trial, a moisturizer containing Matrixyl (a few drops) significantly reduced fine lines/wrinkles after just 12 weeks of application. The trial involved 93 Caucasian female subjects with ages ranging from 35 to 65 years. [R]

Matrixyl and Dark Circles

In addition to compiling the results, the above study’s authors asked the female subjects to perform self-assessments. Members of the Matrixyl group reported a reduction in age spots and dark circles. They also noted that the skin’s firmness increased. [R]

Matrixyl and Collagen

In an in vitro study, it was shown to penetrate the skin’s epidermis layer and enhance overall collagen synthesis by fibroblasts (cells that contribute to the formation of connective tissue). Collagen plays a role in strengthening your skin. It also potentially keeps skin sagging at bay. [R][R]

Matrixyl and Skin Elasticity

In a clinical trial involving 60 volunteers with no history of skin diseases, twice-daily application for 8 weeks increased skin elasticity on the forearm by 41.3%. Depletion of skin elasticity leads to signs of aging and strips of vibrant skin and a youthful appearance. [R][R]

Matrixyl and Skin Hyaluronic Acid

In a preclinical study, the application of Matrixyl 3000 produced a 12.6-fold increase in the expression of hyaluronic acid synthase-1 (HAS1), one of the enzymes that synthesize hyaluronic acid. Hyaluronic acid helps skin stretch and is crucial for younger-looking skin. [R][R]

Frequently Asked Questions

Why is Collagen Essential for Skin?

Collagen gives skin its structure and firmness. It keeps sagging skin at bay. Dermatological research has shown that increased collagen production in the body leads to fewer wrinkles and improved hydration of the skin. That’s why all skincare products aim to boost collagen production.

Has Matrixyl Been Tested With Vitamin C in Clinical Studies?

No clinical or preclinical study has investigated the effects of any Palmitoyl peptides with vitamin C.

Where to Buy Matrixyl Online?

PureRawz is the best place to buy fragrance-free Matrixyl online.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. We sell liquid, powder, and capsule high-quality TUDA formulations. All the formulations are equally high-quality.


It is a synthetic lipoprotein with five amino acids in its chain.

Clinical studies, it has demonstrated the ability to reduce fine lines/wrinkles, improve skin elasticity and firmness, and reduce age spots and dark circles. Preclinical studies have shown that it can help your body produce more collagen and hyaluronic acid. Pure Rawz sells Matrixyl for laboratory research use only.



This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority – if you are not 100% satisfied with the product you received, please contact us at [email protected]

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.

14 reviews for Matrixyl

  1. Anonymous (verified owner)

    Good product

  2. Samuels Jacob

    I ordered two wrong products from you, and your customer service was really amazing with the entire process. Really impressed with your team.

  3. Jim

    I highly recommend this product.

  4. Allen Campbell

    At my age, early fifties, this is an excellent product

  5. Ramps J

    Though it did not arrive on time it’s still worth the wait. The quality of this product is superb. Thank you for helping me out until I received it.

  6. Marshall Drake

    This stuff works wonders on lines on my face.

  7. Carl Tyler

    I saw such great improvements!

  8. Sanford Stokes

    My wife really likes how this is working for her skin!

  9. Jenny

    I’ve been using this product for almost 2 weeks now, and I can already tell a difference. My skin’s texture is smoother.

  10. S Hahn

    I really love this product! I’ve never had any issues with any products from you guys. Thank you for having a good experience with you.

  11. Albert

    It’s working great on my skin so far.

  12. Edward Turner

    Great value for the price! I will definitely order this product again.

  13. Amy

    As usual, the product and quality are excellent.

  14. Verified Buyer (verified owner)

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