NAC (N-Acetyl L-Cysteine) – Product Details

N-acetyl cysteine (NAC) comes from the amino acid cysteine, a sulfur containing amino acid, or L-cysteine. Proteins are composed of these amino acids which are often referred to as building blocks. NAC is an FDA-approved medication with numerous potential  applications.

As an antioxidant, N-acetyl cysteine may help to prevent cancer. It is a medication that medical professionals use to treat acetaminophen (Tylenol) toxicity. It also functions by potentially binding the toxic acetaminophen forms produced in the liver and as a result enhancing liver health.

N-Acetyl L-Cysteine
CAS Number	616-91-1
Molar Mass	163.195 g·mol−1
Chemical Formula	C5H9NO3S
IUPAC Name	(2R)-2-acetamido-3-sulfanylpropanoic acid

What is NAC?

As mentioned above, Cysteine is a semi-essential amino acid and is available synthetically as N-acetyl cysteine (NAC). Upon ingestion, NAC decomposes into cysteine, which is then converted into glutathione. Glutathione is an essential antioxidant for healthy immune system operation, detoxification, tissue synthesis, and repair.

There are a number of potential health benefits associated with n acetyl cysteine supplements and stable form NAC research, including enhanced mental health, balanced immune system function to some viruses, and relief from respiratory problems. However, many of these benefits haven’t received FDA approval (FDA).

NAC Research

Researchers have investigated the potential for n acetyl cysteine as a dietary supplement to help treat a wide variety of health issues. Some research indicates that NAC may help in the following ways:

FDA Approved for Acetaminophen Poisoning

The FDA has approved NAC n acetyl cysteine as a potential treatment for acetaminophen toxicity. Acetaminophen can harm the liver when consumed in high dosages. N acetyl cysteine has shown research potential to lessen the severity of this damage when given orally or intravenously, but it cannot undo damage that has already been done. [R]

Increased glutathione levels, which serve as a potent liver detoxifier, are thought to be how NAC works. The hazardous byproduct of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is then deactivated with the aid of glutathione. But quick administration is essential. According to research, NAC is most effective when administered eight hours or less after taking acetaminophen. [R]

N-Acetyl L-Cysteine May Reduce Symptoms of Respiratory Disease

NAC may be a potential successful treatment for some respiratory tract disorders, including chronic bronchitis and chronic obstructive pulmonary disease, according to evidence (COPD). [R]

Inflammation and excessive mucus production are common features of several of these disorders of the airways. Mucus is produced by the body to protect itself from airborne pathogens, but too much of it can impair breathing and weaken the lungs.

As mucus secretions in the airways are potentially broken up and made thinner by n acetyl cysteine , it should be simpler to cough out and clear the airway. This may result in better respiratory health.

N-Acetyl L-Cysteine May Aid Mental Health Conditions

Preliminary research suggests that NAC may help treat some mental health issues. [R]

Schizophrenia

A small 2018 study found that using NAC in combination to antipsychotic medication reduced the symptoms of schizophrenia. The compound was linked to improvements in negative symptoms such emotional expressiveness, productivity of thought and speech, motivation, and attention span. [R]

Depression

According to one analysis of data from numerous individual trials (containing data from 574 depression sufferers and healthy volunteers), NAC has the potential ability to improve depressive symptoms and general daily functioning within three to six months of administration. [R]

Additionally, through a reduction in oxidative stress in the brain, NAC may potentially regulate mood. One study on 76 depressed patients found that those who took NAC had increased antioxidant levels in their brains. [R]

Bipolar Disorder

NAC is now being studied in the lab for its ability to treat bipolar disorder patients’ chronic health problems, such as heart disease and hormone abnormalities.

One exploratory small-scale investigation found that in 51% of bipolar patients with cardiovascular or hormonal problems, NAC had an indirect impact on overall health, antioxidant status, and inflammation. [R]

While the available scientific data so far only comes from small-scale studies, larger clinical studies are currently underway to investigate the potential benefits of NAC for bipolar disorder. Purerawz sells NAC for research purpose only.

Obsessive Compulsive Disorder

By regulating glutamate and raising antioxidant levels in the brain, NAC may aid in the treatment of OCD. Even in patients with rather severe cases of OCD, augmenting with NAC as an addition to regular drugs was observed to alleviate symptoms in a study of 44 OCD patients. [R]

In a research involving 48 OCD patients who had previously not responded to traditional pharmacological treatments, NAC was found to alleviate symptoms after 3 months of supplementation with no significant rates of negative side effects. [R]

Finally, a fairly comprehensive evaluation found that NAC appears to have relatively few adverse effects and may have a major future promise for treating obsessive-compulsive disorders. [R]

Autism

Early studies suggest that NAC may one day be used to treat some of the symptoms connected to autism.

For instance, a preliminary small-scale investigation found that supplementing 33 autistic children with NAC for three months reduced their irritability.[R]

In two further studies including a total of 80 autistic children, those who added NAC supplementation to two months of antipsychotic (risperidone) therapy reported having decreased agitation and hyperactivity. [R][R]

Cognition

Very early research suggests that NAC supplementation may have some potential benefits for cognition, particularly in older individuals with age-related cognitive decline or certain neurodegenerative illnesses.

For instance, NAC and a number of other antioxidant substances have been used in combination to treat healthy older adults with mild cognitive impairment (MCI), and these results have been found to improve cognition.[R] [R]

These findings raise the question of whether NAC itself specifically caused these cognitive advantages or whether younger populations would experience a similar range of cognitive effects.

Additionally, preliminary studies are being conducted to examine the potential effectiveness of NAC supplementation for treating some cognitive deficits associated with Alzheimer’s disease, Parkinson’s disease, and schizophrenia as well as its potential to enhance cognitive outcomes following anesthesia-related surgical procedures.[R]

Addiction

Some researchers have hypothesized that NAC may have some potential to aid in the treatment of various forms of addiction based on a few early observations from investigations of animal models of binge eating. [R]

NAC may be potentially useful for treating cannabis and cocaine addictions, according to a large-scale analysis of data from nine different studies, which included a total of 165 addiction patients. Although the evidence for these uses is somewhat less and less clear, the authors of this study also propose that NAC may be useful for treating other addictions, such as nicotine, methamphetamine, and pathological gambling. [R]

N-Acetyl L-Cysteine Might Support Healthy Brain Function

NAC may help enhance brain function and lessen symptoms of several neurodegenerative disorders, such as Alzheimer’s and Parkinson’s, according to some research. Additionally, it might lessen neuropathic pain brought on by injury to the central nervous system. [R]

The effects of NAC on brain health need to be confirmed by additional research. Nevertheless, the dietary supplement’s capacity to raise glutathione levels and assist in the prevention of oxidative stress—a disruption in the equilibrium between the generation of free radicals and antioxidant defenses that can result in cell damage—may be a factor in its neuroprotective effects.

NAC and Viral Infections

The clinical research on NAC’s potential efficacy against SARS-CoV-2 are ongoing. According to clinical studies, the severity, duration, and frequency of influenza, common colds, recurrent bronchitis, and recurrent pneumonia can all be potentially reduced with n acetyl cysteine . [R]

According to research, n acetyl cysteine prevents the replication of viruses, strengthens the immune system, and fights viral illnesses. N acetyl cysteine and its antioxidant function might be helpful for those with viral infections, but more research is required to validate these effects. [R]

N-Acetyl L-Cysteine and Male Infertility

According to certain research, NAC may help infertile men’s sperm quality and lower oxidative stress.

According to a small 2019 study, men who used n acetyl cysteine for three months had considerably higher sperm counts and motility (the sperm’s capacity to move effectively). [R]

The results also imply that n acetyl cysteine might lessen sperm DNA damage and aid to correct abnormal sperm structure.

Based on these findings, it is thought that n acetyl cysteine may increase overall sperm quality and, as a result, may aid in the treatment of male infertility.

N-Acetyl L-Cysteine and Chronic Kidney Disease

A disorder known as chronic kidney disease (CKD) is when your kidneys are harmed and unable to operate correctly. Due to the body’s inability to eliminate waste and extra fluid, other health issues, such as high blood pressure and heart disease, arise.

According to certain studies, taking NAC may be able to stop the course of CKD. These results, however, are refuted by other investigations. The usefulness of n acetyl cysteine in CKD needs more investigation. [R]

FAQs

N-acetylcysteine vs. l-cysteine

To maintain normal function, the body requires 20 amino acids. 11 of those can be produced by the body on its own, so a person does not require food to obtain them. One of these amino acids is L-cysteine.

NAC is transformed by the body into the non-essential amino acid l-cysteine. L-cysteine is then utilized by the body to create glutathione, a tripeptide or chain of amino acids made of cysteine, glycine, and glutamic acid. [R]

Antioxidant glutathione performs a variety of vital bodily processes, including DNA synthesis, immune system support, immune system support, support for particular enzyme functions, support for specific organ functions, and more.

The rate at which glutathione is produced in the body is thought to be constrained by the amount of l-cysteine present in cells. Therefore, increasing the supply of l-cysteine can raise this rate and present healthy glutathione levels. NAC is frequently used in supplements rather than l-cysteine alone because it may be less toxic and more soluble. [R]

Where to Buy NAC Online

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