Oleoylethanolamide OEA (Powder) – Product Details

Oleoylethanolamide(OEA) is a naturally occurring weight, cholesterol, and appetite regulator. The metabolite is synthesized in small amounts in the small intestine. The natural molecule is responsible for the feeling of fullness after eating. [R]

Oleoylethanolamide regulates body fat by binding to the peroxisome proliferator-activated receptor alpha (PPAR-Alpha). This natural metabolite boosts body fat metabolism and alerts your brain that you’ve had enough food and should stop eating. [R]

Oleoylethanolamide also increases non-workout calorie expenditure. [R]

Even though OEA is believed to provide weight-loss benefits, it is still recognized as an experimental chemical.

This fact suggests that OEA must be purchased only for laboratory and research purposes.

What is Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) refers to a naturally occurring ethanolamide lipid mediator that impedes food intake by activating the nuclear receptor peroxisome proliferator-activated receptor- (PPAR-).

OEA is derived from oleic acid, a monounsaturated fatty acid produced in the small intestine that has beneficial effects on body composition and regional fat distribution. It aids the body in the absorption, storage, and utilization of fat.

The role of OEA in modulating food consumption and body weight gain makes it an appealing molecule that warrants further investigation in obesogenic environments. Thus, the usage of OEA is strictly restricted to laboratory-controlled studies only.

Oleoylethanolamide synonyms include n-oleoylethanolamine, 111-58-0, and oleoylethanolamide OEA 98.

Possible Applications of Oleoylethanolamide OEA

Oleoylethanolamide OEA and Depression

Uncontrollable chronic stress is a significant risk factor for metabolic and psychiatric disorders. [R]

The current study on animal models found that repeated daily treatment with Oleoylethanolamide OEA prevented chronic social stress-induced social interaction deficits and short-term memory impairment. [R]

This application still requires more research studies.

Oleoylethanolamide OEA and Obesity

According to laboratory studies, oleoylethanolamide OEA, an endocannabinoid-like compound, causes satiation or inhibits food intake via PPAR activation and fatty acid translocase (FAT)/CD36. [R]

Furthermore, the lipid-amide OEA promotes food intake control by stimulating fatty acid uptake, lipolysis, and beta-oxidation. OEA promotes satiety by activating hedonic dopamine pathways and increasing homeostatic oxytocin and brain histamine levels. [R] [R]

To summarize, OEA may be a vital component of the physiological system involved in regulating dietary fat consumption and energy homeostasis; thus, it is proposed that oleoylethanolamide OEA has anti-obesity effects and may be used as a potential therapeutic agent for the management of obesity. [R] [R]

Despite OEA’s potential to help obese people burn fat, such chemical quality is still subject to more in-depth research.

Oleoylethanolamide OEA and Parkinson’s Disease

Oleoylethanolamide (OEA) is a peroxisome proliferator-activated receptor (PPAR) alpha agonist that has been shown to have neuroprotective properties when administered locally in animal models of a variety of neurological disorders, including stroke and Parkinson’s disease. [R]

Still, there is lacking conclusive results about OEA’s positive effect on Parkinsons’ disease.

Oleoylethanolamide OEA and Oxidative Stress

Laboratory findings suggest that OEA reduces fatty liver, liver damage, oxidative stress, and ER stress in the livers of HFD-fed rats via a mechanism that involves Nrf1 and Nrf2, thus broadening OEA’s previously known anti-obesity effects to new targets. [R]

Mechanisms of Action

Oleoylethanolamide (OEA) acts as an appetite suppressant. Oleoylethanolamide regulates food intake by signaling to the brain that the subject is full and it’s time to stop eating. As a result, they consume less food daily, and their bodies stop packing on weight over time. [R]

Oleoylethanolamide (OEA) is synthesized and mobilized in the small intestine from dietary oleic acid. Foods high in fat can inhibit Oleoylethanolamide production in the proximal small intestine. [R]

By stimulating histamine brain circuitry, homeostatic oxytocin, and hedonic dopamine pathways, oleoylethanolamide reduces food intake. It is clear that oleoylethanolamide can also suppress CB1R signaling, which, when activated, can lead to increased food intake. To reduce lipid transport into adipocytes, oleoylethanolamide is administered.

OEA also stimulates PPAR, which lowers fat storage while increasing fat burning. When you eat, your OEA levels rise while your appetite decreases. Because of the PPAR-, the sensory nerves connected to your brain informing it that you are full. PPAR- is a ligand-activated nuclear receptor involved in energy homeostasis pathways and lipid metabolism gene expression. [R]

As a GPR119 agonist, OEA is being studied as a possible treatment for diabetes. GPR119 has been implicated in controlling insulin release by pancreatic beta-cells and GLP-1 secretion by gut enteroendocrine cells in vitro. [R]

Further studies are still needed before we can safely say that OEA is a cure for diabetes.

Safety and Side Effects of Oleoylethanolamide

Because there are still small-scale studies about OEA, the chemical has no recorded serious side effects. However, we still recommend using this product cautiously by buying it for research purposes alone.

Frequently Asked Questions

What is oleoylethanolamide used for?

Oleoylethanolamide (OEA) is a molecule in the intestines that the body produces. It is in charge of the feeling of fullness after eating. More research is needed to determine whether taking OEA orally can help with weight loss.

Is oleoylethanolamide an endocannabinoid?

OEA is a shorter, monounsaturated analog of the endocannabinoid anandamide, but unlike anandamide, it acts independently of the cannabinoid pathway to stimulate lipolysis by regulating PPAR- activity.

Where can you buy oleoylethanolamide?

PureRawz is the best place to buy oleoylethanolamide online. By visiting our website, you’ll discover more research chemicals that you may use for your research studies. Our wide selection of peptides and nootropics should be able to help you in your clinical studies.

In order to be the best research peptides supplier, we provide reference materials with every product we sell. Each of our research peptides comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

PRODUCT TYPE	POWDER
Product Name	Oleoylethanolamide (OEA) 98%
Application	Scientific
CAS	111-58-0
Molar Mass	325.537 g·mol−1
Chemical Formula	C20H39NO2
IUPAC Name	(Z)-N-(2-Hydroxyethyl)octadec-9-enamide
Synonyms	N-(Hydroxyethyl)oleamide, N-(cis-9-Octadecenoyl)ethanolamine, OEA, oleoylethanolamide
Storage	Minimize open air exposure, store in a cool dry place
Terms	Kindly make yourself aware of the scientific uses of this product, and make sure to read the Terms and Conditions before making a purchase. By completing your order and making the payment, you agree to our Terms and Conditions. Please note that the packaging of the product might be slightly different than what is shown on the website. In case you are not 100% satisfied with the product you receive, you can contact us at support@purerawz.co. We will be glad to help you as customer satisfaction is our top priority.   ATTENTION: All Purerawz products are strictly restricted to LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used on humans or animals.