Silymarin (Milk Thistle)


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Silymarin (Milk Thistle) – Product Information

Silymarin is a natural compound derived from the seeds and fruit of the milk thistle plant (Silybum marianum). It is a mixture of several flavonolignans, including silybin, silydianin, and silychristin, and has been studied for its potential health benefits, particularly in supporting liver health and function.

CAS Number 65666-07-1
Molar Mass 482,44 g/mol
Chemical Formula C25H22O10
IUPAC Name (2R,3R)-3,5,7-trihydroxy- 2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl) -2,3-dihydrobenzo[b][1,4]dioxin-6-yl]chroman-4-one

What are Silymarin 98% capsules?

Silymarin 98% capsules are a concentrated compound made from milk thistle (Silybum marianum) seeds and contain an extraordinarily high amount of silymarin, the main active ingredient in milk thistle seed extract. Silymarin is well known for its potential ability to support liver health and shield liver cells from harm brought on by pollutants, free radicals, and oxidative stress. These capsules are frequently researched as a potential natural medicine to improve liver function, detoxification procedures, and general well-being. [R]

How It Works

Silymarin, the main active ingredient in milk thistle, is a key part of how its potential effects work. It may help fight inflammation and is potentially a good antioxidant. Once silymarin is administered, it has the potential to get into the bloodstream and go straight to the liver. Silymarin may then have the potential to protect liver cells from free radicals, which are waste products of metabolism that can harm liver cells. As an antioxidant, silymarin may potentially help to get rid of these free radicals. This could potentially keep the liver’s hepatocytes, or liver cells, from getting hurt by toxins like alcohol, drugs, and environmental pollutants. Also, silymarin may have the potential to help the body make more enzymes that are needed for detoxification. This helps the liver do its important job of getting rid of harmful substances from the body. Its anti-inflammatory properties can help reduce inflammation in the liver and improve liver health as a whole.[R] [R]

Silymarin 98% Research

Numerous studies have been conducted on the potential application of Silymarin. Below are some of the relevant findings on Silymarin:

Silymarin as Anti-inflammatory

One of silymarin’s possible advantages for numerous aspects of health is the anti-inflammatory effects it may have. Two silymarin compounds, silybin A and B, have been demonstrated to have a dose-dependent ability to inhibit T-cell proliferation and proinflammatory cytokine release in vitro studies. Silymarin has been demonstrated to have anti-inflammatory and antioxidant properties that guard against inflammation and reperfusion injury. In terms of preventing skin cancer, silymarin has also been found to have immunomodulatory qualities and to lessen inflammation. Silymarin has anti-inflammatory qualities in part because it scavenges free radicals and regulates enzymes linked to the onset of cellular damage, fibrosis, and cirrhosis. [R] [R] [R]

Silymarin on Skin Cancer

Silymarin, a natural compound derived from milk thistle seeds (Silybum marianum), is gaining attention for its potential benefits in the field of skin cancer research. Skin cancer, often triggered by factors like exposure to harmful chemicals and solar ultraviolet (UV) radiation, is a significant concern worldwide. While sunscreen is commonly used for protection, it may have limitations such as incomplete spectral coverage and potential toxicity. This is where silymarin steps in. Research indicates that silymarin has shown promise as a chemopreventive agent against both chemical and UV-induced skin carcinogenesis in animal models. When applied topically, silymarin has been found to inhibit the development of skin tumors in mice exposed to various tumor-promoting agents. What’s intriguing is that silymarin appears to possess antioxidant, anti-inflammatory, and immunomodulatory properties, making it a potentially valuable tool in the prevention of skin cancer. While silymarin’s benefits have primarily been demonstrated in animal studies, it holds promise as a safe and effective candidate for further exploration in human skin cancer research. Additionally, silymarin may complement traditional sunscreen protection, providing an extra layer of defense against the risk of skin cancer from UV radiation.[R] Still it is important to consult a physician for cancer-related illnesses.

Silymarin on Cardiovascular diseases

Cardiovascular diseases (CVDs) are a major global health concern, often associated with serious health risks. One key factor contributing to these heart-related issues is oxidative stress, which essentially means an imbalance in harmful molecules in our bodies. This imbalance can lead to various CVDs like atherosclerosis, hypertension, and heart problems. Researchers are exploring new avenues to tackle this issue, and one intriguing area of study is Silymarin.

Silymarin is a natural compound known for its antioxidant properties. When cells experience oxidative stress, they release harmful molecules that can damage vital cell components like proteins, DNA, and lipids, setting the stage for heart problems. Silymarin steps in as a protective shield against these harmful effects, potentially offering protection against oxidative stress-induced hypertension, atherosclerosis, and cardiac toxicity. Silymarin is emerging as a fascinating subject of study for researchers aiming to understand and address cardiovascular diseases. While it’s not for human use, Silymarin’s potential benefits for research purposes could lead to new insights into managing and preventing CVDs.[R] 

Silymarin as Hepatoprotective

One of the standout qualities of Silymarin is its ability to potentially act as a shield for the liver. This compound works as a potent antioxidant, battling against harmful free radicals that can arise from the breakdown of toxic substances like ethanol, acetaminophen, and carbon tetrachloride. These free radicals can wreak cellular membranes, leading to lipoperoxidation – a process that can harm the liver. Silymarin steps in to bolster the liver’s antioxidant defenses by enhancing the levels of glutathione. Additionally, it aids in protein synthesis within hepatocytes, showcasing its potential to boost liver function. While research continues, some studies have even suggested that Silymarin might contribute to the improved survival of individuals with cirrhotic alcoholism. Remember, though, that this research is for scientific purposes only, and the compound is not intended for human use outside of controlled research settings. [R] 

Silymarin on the Immune system

Silymarin, extracted from the Silybum marianum plant, is a versatile compound that plays a fascinating role in influencing the immune system.  Research has revealed that silymarin possesses immunomodulatory properties, capable of both boosting and calming our immune responses. At lower doses, it restrains the activity of T-lymphocytes, helping to regulate the immune system, while at higher doses, it can stimulate certain inflammatory processes. This dual-action ability makes it a compelling subject for study. Scientists have found evidence that silymarin may have applications in addressing a wide range of immune-related conditions, including autoimmune diseases, allergies, and cancer, and may support healthy liver function Moreover, it shows promise in protecting against the damaging effects of oxidative and nitrosative substances on the immune system. While much has been uncovered about silymarin’s effects, ongoing research is essential to unlock its full potential for the treatment of medical conditions related to immune diseases in humans. [R] 

Silymarin on Enhancing Growth and Lowering HDL and ALT, AST Levels

Milk thistle extract is the name of a plant in the Asteraceae family that looks matte green as its natural color variation and has prickly leaves. One of its most important parts is silymarin, which is mostly found in the plant’s seeds and makes up between 70% and 80% of flavonolignans. It also has between 20% and 30% of polymeric and oxidized polyphenolic compounds, such as tannins. Throughout history, milk thistle extract has been traditionally used for various purposes. It has been relied upon to boost milk production, alleviate menstrual cramps, reduce depression, mitigate gallstones and jaundice, and enhance the functions of the liver, spleen, and kidneys. Recent studies have delved into its effects on Japanese quail when incorporated into their diet. These studies found that including milk thistle powder at levels of 0.5% and 1% significantly improved feed intake, body weight, and the quality of carcass components. Moreover, it led to positive changes in blood components such as increased levels of total protein and albumin, while reducing harmful factors like HDL, ALT, and AST. The addition of milk thistle also showed promise in enhancing the overall antioxidant capacity of the quail’s blood plasma. Notably, it increased white blood cell count, calcium, vitamin D3, and albumin levels while decreasing the relative weights of the bursa of Fabricius and the spleen. These findings give additional support that milk thistle holds the potential to enhance growth performance, improve feed conversion ratios, and bolster the immune system in quail, shedding light on its intriguing possibilities for scientific studies purposes. [R] 

Silymarin Potential Side Effects

Silymarin, derived from milk thistle, liver has a long history of research by traditional herbalists; however, further research is recommended to fully understand its effects. Despite its traditional use by herbalists, potential side effects include gastrointestinal symptoms, headaches, allergic reactions, immunomodulatory effects, lowered blood sugar, and a mild laxative effect.[R][R]

Where to Buy  Silymarin   Online

At PureRawz, your number one source for buying Silymarin milk thistle capsules online, we have, a high degree of commitment to excellence. Our product is the gold standard, providing an equivalent number of benefits for your research needs This product may also be offered in vegetarian formula, at 150 mg with milk thistle dandelion and is alcohol-free.

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Silymarin 98% is a potent nutritional supplement derived from milk thistle seeds, known for their remarkably high silymarin content. Silymarin, the primary active ingredient in milk thistle, is renowned for its liver-supporting properties and its ability to shield liver cells from the harm caused by pollutants, free radicals, and oxidative stress. This supplement is commonly used as a natural remedy to enhance liver function, support detoxification processes, and promote overall well-being. Additionally, it holds potential benefits for cardiovascular health, immune system modulation, and skin cancer prevention.

The ingredients in Silymarin 98% work in synergy to provide these potential benefits. Silymarin, with its anti-inflammatory and antioxidant properties, plays a central role in protecting liver cells from damage and aiding detoxification. It also shows promise in addressing cardiovascular diseases by combatting oxidative stress. Furthermore, silymarin demonstrates potential in preventing skin cancer through its antioxidant, anti-inflammatory, and immunomodulatory qualities. Additionally, it possesses immunomodulatory capabilities that could have applications in various immune-related conditions. While silymarin is known for its hepatoprotective qualities, it may also enhance growth and lower HDL, ALT, and AST levels in research contexts, as seen in studies with Japanese quail. However, it’s important to note that the use of silymarin is intended for scientific research purposes and not for human consumption outside of controlled research settings.


This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

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