How Does Stenabolic Work?

Stenabolic (SR-9009) works by binding to REV-ERBα in the body.

REV-ERBs are proteins that regulate circadian rhythms (24-hour cycles that are part of the body’s clock). Circadian rhythms carry out various crucial functions in the body. These include eating habits and digestion, cycles of alertness and sleepiness, and body temperature. [R]

REV-ERBs are also proven to promote fat burning and turn off genes responsible for storing fat. In an In Vivo study, treatment of diet-induced obese mice with a REV-ERB agonist (SR9009) decreased obesity by reducing fat mass. [R] [R]

Stenabolic Research

Various animal studies have been conducted on Stenabolic (SR-9009). These have demonstrated the positive effects of this research compound on lipid and glucose metabolism, skeletal muscle growth, blood cholesterol levels, endurance, and other functions.

However, since its development by researchers at the Scripps Research Institute, SR-9009 is yet to undergo any clinical trial. The available clinical data is thus insufficient to claim that it is safe for human consumption. Randomized long-term clinical trials are needed.

Stenabolic and Fat Mass

In an animal study, SR-9009 treatment resulted in a decrease in fat mass and plasma lipids in diet-induced obese mice. After 12 days of dosing, SR-9009 suppressed the degree of weight gain normally observed in leptin-deficient mice. [R]

Stenabolic and Blood Cholesterol

In another animal study, genetically modified mice were administered Stenabolic for eight weeks. The mice were on a high-cholesterol diet to obtain a fat profile similar to humans. Stenabolic treatment reduced total cholesterol, triglycerides, and LDL, though HDL cholesterol was unaffected. [R]

Stenabolic and Endurance

Mice treated with Stenabolic ran significantly longer, both in time and distance, than mice treated with the vehicle, per a study conducted by scientists at Institut Pasteur de Lille in France. The researchers found that Stenabolic increased the running capacity by 50 times. [R]

Stenabolic and Heart Health

Atherosclerotic plaque size was significantly reduced (p<0.05) in mice administered SR-9009 (100mg/kg) for seven weeks compared to control mice. These results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for the treatment of atherosclerosis. [R]

Stenabolic and Inflammation

In a study involving rats with ventilator-induced lung injury (VILI), SR-9009 treatment greatly diminished VILI-induced lung edema, inflammatory cell infiltration, and the production of the pro-inflammatory cytokine TNF-α (the protein that causes inflammation in response to infection). [R]

Stenabolic and Wakefulness

In a report, researchers examined the effects of REV-ERB agonists on patterns of sleep and wakefulness and found that the compounds increase wakefulness. Furthermore, it was found during the analysis that the compounds also decreased anxiety-like behavior. [R]

However, mice treated with SR-9009 returned to normal patterns of wakefulness/sleep 12 hours after administration.

SR-9009 FAQs

Is SR-9009 Legal?

While it is banned by the World Anti-Doping Agency (WADA), SR-9009 Stenabolic is legal to buy and sell as a research compound for laboratory research use.

Is SR-9009 A SARM?

SR-9009 isn’t a selective androgen receptor modulator. It is a synthetic REV-ERBa agonist and has been used to demonstrate that pharmacological targeting of REV-ERBs may be useful in treating circadian disorders, such as metabolic syndrome.

Does SR-9009 Burn Fat?

In diet-induced obese mice, SR-9009 treatment resulted in a decrease in fat mass. Longer randomized trials are needed to verify the anabolic effects of Stenabolic in select populations. Longer randomized trials are needed to verify whether significant fat loss is possible in select populations.

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SR-9009 Summary

SR-9009 is a synthetic REV-ERBa agonist that has been shown to increase endurance, decrease fat mass, and reduce blood cholesterol levels in animal studies. However, long-term randomized clinical trials are needed to verify its safety and efficacy in select populations.