What is Tianeptine?

As mentioned above, Tianeptine is a stimulant mostly used to treat severe depressive disorder, but it has also been researched to treat irritable bowel syndrome (IBS). [R]

It is structurally categorized as a tricyclic antidepressant (TCA), but its pharmacological characteristics differ from those of standard tricyclic antidepressants. [R]

The French Society of Medical Research discovered and patented tianeptine in the 1960s. [R]

Currently, Laboratories Servier SA, which produces and sells tianeptine, has obtained regulatory approval to do so in France. It is also sold under the brand names “Stablon” and “Tatinol” in Asia (including Singapore) and Latin America but is not currently available in Australia, Canada, New Zealand, the United Kingdom, or the United States.

Purerawz sells all forms of Tianeptine for research purposes only.

How Does Tianeptine Work?

According to recent investigations, tianeptine fully agonistically activates the mu opioid receptor (MOR). [R] [R] The mu-opioid receptors are being researched as potential antidepressant therapy targets, mostly due to their potential as a selective serotonin reuptake enhancer. [R] It is thought that tianeptine’s regulation of these receptors is what causes the therapeutic effects it has shown. [R]

Previous research has linked its effects on the serotonin receptor, dopamine (D2/3) receptors, and glutamate receptors, in addition to its effects on the opioid receptor, as will be addressed below: [R] [R] [R]

Tianeptine has contested the monoaminergic theory of depression as well as the widely accepted monoaminergic processes that have been used to explain the effects of the majority of well-known antidepressants. [R] The hippocampus CA3 commissural associational synapse’s glutamate receptor bursting is specifically thought to be persistently altered by this medication. [R]

According to recent studies, tianeptine affects the production of brain-derived neurotrophic factor (BDNF), which affects neuronal plasticity, and glutamate receptor activity (such as AMPA and NMDA receptors), to create its antidepressant effects. [R] The significance of tianeptine in regulating glutaminergic activity in the amygdala, the emotional part of the brain connected to memories, is supported by more recent research.

Tianeptine lessens the hypothalamic-pituitary-adrenal reaction to stress, hence preventing behavioral problems brought on by stress. The effect of acute constraint on mice’s extracellular glutamate levels in the basolateral amygdala was decreased by tianeptine. [R]

Unaffected by the presence of stress, the SSRI fluoxetine raised basolateral amygdala extracellular glutamate levels. These findings support the theory that the mechanism of action of tianeptine involves altering glutaminergic activity in the amygdala and the hippocampus and show that it differs from that of SSRIs.[R]

Tianeptine is a special antidepressant and anxiolytic substance that enhances serotonin (5-hydroxytryptamine; 5-HT) and 5-hydroxy indole acetic acid (5-HIAA) uptake in brain tissue, in addition to the aforementioned processes.

Although serotonin (5-HT), noradrenaline (NA), and dopamine (DA) are monoaminergic neurotransmitters that have been linked to the development of depressive disorders, it is now understood that monoamine deficiencies do not fully account for how antidepressant drugs work. [R]

Tianeptine Research

Numerous clinical studies and trials on human and animal models have been done on Tianeptine. Below we will highlight some of the potential future research implications of Tianeptine:

Tianeptine and Depression

As an antidepressant tianeptine is similar to amitriptyline, imipramine, and fluoxetine, tianeptine exhibits efficacy against major depressive episodes, but with much fewer adverse effects. [R]

In a group of patients with concurrent major depression and anxiety, it was found to be more beneficial than maprotiline. [R]

According to a study, tianeptine exhibits significant anxiolytic properties and is effective in treating a variety of anxiety disorders, including panic disorder. Participants who received 35% CO2 gas (carbogen) while receiving paroxetine or tianeptine therapy exhibited similar panic-blocking effects. [R]

It may also improve cognition in persons with depression-related cognitive dysfunction, just like many antidepressants do (including bupropion, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, moclobemide, and countless others). [R]

Tianeptine is beneficial in treating men with erectile dysfunction and depression, according to a 2005 Egyptian study.[R]

Tianeptine has also been found to be just as safe and effective as fluoxetine and moclobemide for treating post-traumatic stress disorder, Parkinson’s disease, and depression. [R] [R] [R]

Tianeptine and Irritable Bowel Syndrome

In clinical research comparing its effectiveness and tolerability with that of amitriptyline in the management of irritable bowel syndrome, tianeptine was found to be at least as effective and to have less noticeable side effects, such as constipation and dry mouth. [R]

Tianeptine and Asthma

Asthma patients and respiratory depression have shown great success with tianeptine. The findings of a 52-week randomized controlled study of asthmatic children were published in August 1998 by Dr. Fuad Lechin and colleagues at the Central University of Venezuela Institute of Experimental Medicine in Caracas. The children in the groups that received tianeptine had a significantly lower clinical rating and improved lung function. [R]

They discovered a strong, significant correlation between free serotonin levels in plasma and the severity of asthma in those who were exhibiting symptoms two years prior.

They chose to utilize tianeptine to investigate if lowering plasma levels of free serotonin would be beneficial as it was the only medication known to decrease free serotonin and increase serotonin uptake in platelets.

Two double-blind placebo-controlled crossover trials and a seven-year open-label research with less than 25,000 participants both showed efficacy by November 2004. [R]

Tianeptine and Pain

In addition to its analgesic and anticonvulsant properties, tianeptine also has anticonvulsant properties. [R]

A clinical trial conducted in Spain that was completed in January 2007 revealed that tianeptine is beneficial in treating fibromyalgia-related pain. [R]

Tianeptine and Attention Deficit Disorder

The effectiveness of tianeptine in the treatment of attention-deficit hyperactivity disorder has been demonstrated, and its adverse effects are kept to a minimum. [R]

FAQs

What is the Legal Status of Tianeptine in the US?

Except for Michigan, Minnesota, and Alabama, where it is now regarded as a scheduled prohibited substance, tianeptine is legal in the United States. Tianeptine is not an approved food additive, it is not a dietary item, and the FDA does not typically consider it as safe for human ingestion and as a result, is not FDA approved.

Purerawz sells Tianeptine for Research Purposes as a research chemical only.

Can Tianeptine be Addictive in Subjects?

When tianeptine is used improperly for its opioid-like qualities, studies indicate substantial potential for addiction. It is known that long-term abuse of tianeptine at high doses results in withdrawal symptoms that are on par with other opioid drugs, if not worse.

In Europe, tianeptine abuse and addiction are well-documented problems, and there are an increasing number of tianeptine addiction cases being reported in the United States and poison control centers.

Where to Buy Tianeptine Online

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