How Does Trestolone Acetate Work?

Trestolone acetate works by inhibiting the release of follicle-stimulating hormone (FSH) in the body. This results in impaired spermatogenesis. Trestolone also suppresses luteinizing hormone (LH), causing decreased testosterone production.

Testosterone Vs Trestolone

Testosterone and trestolone can both impair spermatogenesis. What distinguishes trestolone is that it does not undergo 5 alpha- reduction in the prostate as does testosterone. This means that it might be less prone to cause diseases of the prostate than T. [R]

A preclinical study found Trestolone and Testosterone as effective replacement therapies to stimulate bone and muscle in hypogonadal rats. However, trestolone reduced fat mass and suppressed bone turnover rate to a greater extent than T. [R]

Pharmacokinetic studies performed in men and monkeys showed that MENT, in contrast to testosterone, shows no binding to the sex hormone-binding globulin (SHBG). Furthermore, its metabolic clearance rate (MCR) is much faster than values reported for T. [R]

Trestolone Research

Multiple animal studies have been conducted on trestolone. The synthetic steroid has also attracted at least two studies in men. However, in the absence of large-scale, randomized clinical trials, the full range of effects trestolone acetate can produce remain unclear.

Trestolone and Muscle Growth

The differential bioactivities of testosterone and MENT acetate were investigated in castrated rats. The effects of trestolone on the weights of bulbocavernosus plus levator ani muscles (muscle) were 10 times greater than that of testosterone.

In conclusion, the researchers found that trestolone can maintain muscle mass and normal gonadotropin levels in androgen-deficient rats without hyperstimulating the prostate. These benefits suggest that it may offer some benefits to men who require androgen treatment. [R]

Trestolone and Sexual Behavior

A recent study investigated the effects of MENT on sexual interest and activity, spontaneous erection, and mood states in comparison with testosterone enanthate (TE). 20 Caucasian and Chinese hypogonadal men were recruited in Edinburgh and Hong Kong.

Both MENT and TE treatments resulted in significant increases in sexual interest and activity, spontaneous erection, and increases in positive moods. The results demonstrate that MENT has similar effects on sexual activity and mood as testosterone in hypogonadal men. [R]

Trestolone and Bone Strength

Overt male hypogonadism causes osteoporosis and unfavorable changes in body composition, which can be prevented by testosterone replacement. A preclinical study evaluated the potential of MENT as an alternative treatment for male hypogonadism in comparison with T.

Both androgens restored muscle fiber type composition and trabecular bone volume. Both also stimulated periosteal bone formation but with a stronger effect of T.

In contrast, MENT more strongly suppressed bone turnover rate. [R]

Trestolone and Fat Loss

In the abovementioned preclinical study, trestolone also reduced fat mass. In fact, the lipolytic action of MENT was found to be stronger than testosterone. This shows the massive potential research applications of the anabolic effects that this potent anabolic steroid may possess.

Trestolone FAQs

What is the half-life of Trestolone?

Trestolone acetate has a half-life of 40 minutes.

What are the side effects of trestolone?

Trestolone acetate side effects include low estrogen levels.

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Summary

Trestolone acetate was developed to be used as a potential male contraceptive in injectable form. Multiple studies have shown that it possesses muscle and bone anabolic effects. At least one human study has found that it could increase sexual behavior and activity in males.

Still, long-term randomized clinical trials are needed to verify this drug’s efficacy and safety.