Protirelin (TRH Thyrotropin) – Product Information
Protirelin is a thyrotropin-releasing hormone (TRH), which refers to a small peptide hormone generated in the anterior pituitary gland. TRH research has revealed that it could treat thyroid disorders and may offer anti-depressant and anti-suicidal qualities. This chemical is also thought to promote proper kidney function and may be helpful in treating an overdose of opioids.
It has also been studied for its possible benefits in the aging process, eating behavior, free radical reduction, and autonomic nervous system modulation.
Even though Protirelin seems to produce several health benefits (such as stimulating thyroid function that could prevent thyroid disease), it is still classified as an experimental peptide.
It is not advisable for human consumption.
PureRawz sells protirelin for research purposes only.
|TRH Thyrotropin (Protirelin) Peptide|
|Molar Mass||362.38 g/mol-1|
What is Protirelin?
Thyrotropin-releasing hormone (protirelin) is one of the smallest hormones in the body, made up of only three amino acid building blocks. It is produced by a cluster of nerve cells in the hypothalamus, an area at the base of the brain just above the pituitary gland.
The paraventricular nucleus is the name given to this group of nerve cells. The nerve fibers that emerge from it transport the thyrotropin-releasing hormone and release it into the blood surrounding the pituitary gland, where it has the most impact.
This serves to control the formation and secretion of thyroid-stimulating hormone in the pituitary gland, which in turn controls thyroid hormone production in the thyroid gland. The thyrotropin-releasing hormone has a very short half-life, lasting only a few minutes.
Possible Applications of Protirelin
Below are clinical trials done to determine the possible health benefits of protirelin. Most of these studies are in a dose-dependent manner. Although you may find the results promising, note that these are still insufficient to explain protirelin’s mechanisms of action fully.
As a result, the chemical is not recommended for human treatment or consumption.
TRH Thyrotropin Protirelin and Depression
It is believed that protirelin could become a future treatment for severe depression.
In a double-blind crossover design, eight medication-free in patients with refractory depression received 500 micrograms of protirelin via lumbar intrathecal injection and an identical sham lumbar puncture procedure separated by one week. [R]
As a result, intravenous administration of protirelin induced a rapid improvement in mood and suicidality in these refractory depressed patients, supporting the hypothesis that thyrotropin-releasing hormone could be a positive mood modulator. [R]
TRH Thyrotropin Protirelin and Opioid Overdose
In morphine-treated rats, TRH and talirelin both increased mean arterial blood pressure. TRH, when administered before morphine, prevented morphine-induced changes in ventilation; and TRH rescued all four rats given a lethal dose of morphine. [R]
TRH and taltirelin, like intravenous administration, reversed morphine’s effects on ventilation. TRH or taltirelin may be useful as an intravenous or inhaled antidote to opioid-induced cardiorespiratory depression. [R]
TRH Thyrotropin Protirelin and Motor Memory
TRH is thought to be involved in cerebellar LTD by increasing the basal cGMP level in Purkinje cells and, thus, in motor learning. [R]
TRH Thyrotropin Protirelin and Trauma
Taltirelin hydrate (()-N-[(S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl-carbonyl]-L-histidyl-L-procainamide tetrahydrate; taltirelin), a metabolically stable thyrotropin-releasing hormone (TRH) analog, was studied in urethane-anesthetized rats. [R]
Taltirelin improved arterial pH, bicarbonate ions, and base excess while preventing a drop in arterial oxygen saturation. Taltirelin’s anti-shock effect was found to be more potent than TRH’s. The central muscarinic cholinergic system mediated taltirelin activity. Furthermore, taltirelin corrected metabolic acidosis.
These findings imply that taltirelin may be useful in the treatment of hypovolemic shock. [R]
TRH Thyrotropin Protirelin and Anti-Aging Process
Research in aging mice has allegedly shown that protirelin may protect specific organs from oxidative damage and natural aging. TRH is believed to prevent amyloid buildup, which preserves kidney function amid advancing age. [R]
Studies on the effects of TRH supplementation, whether given parenterally or orally, clearly demonstrate that the neuropeptide delays aging and may even reverse it. Similar to melatonin, TRH is an anti-aging substance with a wide range of activities. [R]
The results imply that TRH may play a crucial role in the control of metabolic and hormonal processes. [R]
How Does Protirelin Work?
Thyrotropin-releasing hormone primarily works by causing the pituitary gland to release more thyrotropin, also referred to as a thyroid-stimulating hormone. The principal regulator of thyroid gland growth and function is thyrotropin-releasing hormone (including the secretion of the thyroid hormones thyroxine and triiodothyronine).
These hormones regulate the body’s metabolic rate, heat production, neuromuscular activity, and heart rate. The hypothalamus will detect a lack of thyroid hormone available for the brain and release a thyrotropin-releasing hormone into the blood, supplying the pituitary gland as a result.
Frequently Asked Questions
Is Protirelin safe?
Researchers are still studying the safety and efficacy of protirelin. This fact suggests that the chemical compound should not be considered a form of treatment for any illnesses. More large-scale studies are required here.
Does Protirelin increase body temperature in subjects?
TRH tartrate dissolved in saline was given intraperitoneally to male Wistar rats weighing 200-250 g at dosages of 1, 5, 10, and 20 mg/kg.
The electronic thermister was inserted 5 cm within the anus to measure the rectal temperature. TRH tartrate caused a temporary increase in body temperature dose-dependently.
Where can you buy Protirelin?
PureRawz is the best place to buy premium quality protirelin for sale.
In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.