Triptorelin (GnRH) – Product Information
It is a gonadotropin-releasing hormone agonist (GnRH), used in research as a potential treatment for advanced prostate cancer and precocious puberty. This compound has been proven to be a potential potent inhibitor of the synthesis of sex hormones – testosterone (in men) and estrogen (in women). [R]
In the EU, it has been approved as a potential adjuvant treatment for breast cancer in women with a high risk of recurrence. Furthermore, various studies have shown that it could be a potentially effective aid when administered to patients with endometriosis. [R][R]
Pure Rawz sells Triptorelin for testing and laboratory experimentation only.
|Triptorelin (GnRH) Peptide|
|Molar Mass||1311.4 g/mol|
What Is Triptorelin?
Triptorelin is an agonist of gonadotropin-releasing hormone (GnRH). GnRH regulates the secretion of luteinizing hormone (LH) and follicular-stimulating hormone (FSH) from the pituitary gland. It has been proven to have the potential to induce a sustained decrease in FSH and LH levels. [R]
This research peptide has also been shown to have the potential to suppress testosterone levels in men with prostate cancer, thereby stopping or preventing the growth of prostate cancer cells. In the EU, but not in the US, it is an approved treatment for advanced prostate cancer in males. [R]
It is an FDA-approved treatment for central precocious puberty (a condition that causes early sexual development) in children aged 2 years and above. In a randomized phase III trial, this synthetic decapeptide had the potential to reverse LH to its prepubertal levels in 93% of patients. [R]
This research peptide has also been approved as a treatment for endometriosis. Endometriosis is a condition in which tissue similar to those that line the woman’s uterus grows outside the uterus. Endometriosis affects 2 to 10% of US women of childbearing age. [R]
PureRawz doesn’t sell Triptorelin for human consumption.
How Does Triptorelin Work?
Here are the working mechanisms of Triptorelin:
Decreases Testosterone Production
Triptorelin works by potentially reducing the amount of testosterone the body makes. This GnRH hormone analog potentially achieves this by stopping the brain from telling the body to produce testosterone. Its ability to lower testosterone levels makes it a candidate for potential androgen deprivation therapy. [R]
Lowers Luteinizing Hormone and Follicular Stimulating Hormone Levels
Triptorelin can potentially lower LH and FSH levels over the long term. It does that by producing a potential initial stimulation of pituitary gonadotrophs. While this may result in a transient increase in LH and FSH levels, a subsequent negative feedback loop causes a sustained decrease in LH and FSH levels. [R]
Multiple large-scale clinical trials have been conducted on Triptorelin, making this research peptide one of the most studied GnRH analogs. These trials have shown that it could be an effective treatment for early-stage breast cancer, prostate cancer, and endometriosis.
Triptorelin and Early Stage Breast Cancer
A 1-month formulation of Triptorelin has been approved in the EU as a potential adjuvant treatment of endocrine-responsive, early-stage breast cancer in women at high risk of recurrence. The potential therapy combines it with tamoxifen or an aromatase inhibitor (AI). [R]
This was done in the aftermath of a study in which the addition of Triptorelin to tamoxifen led to potentially better disease control. The study also demonstrated that combining Triptorelin with tamoxifen had the potential to increase overall survival in high-risk patients who had previously received chemotherapy.
Triptorelin and Prostate Cancer
Research has shown that it could potentially shrink prostate cancer or slow its growth by decreasing testosterone levels in the body. This helps Triptorelin come across as a potentially effective treatment for prostate cancer, which depends on testosterone for survival. [R]
In a randomized trial with an active treatment control group, it had the potential to suppress serum testosterone concentrations to castration levels in 91% of patients with advanced prostate cancer. Reduced castration levels were maintained through day 253 in 96% of patients. [R]
In March 2010, the US Food and Drug Administration (FDA) approved a formulation of Triptorelin pamoate administration for the palliative treatment of advanced prostate cancer. This makes it the only 6-month intramuscular GnRH agonist to be approved by the FDA. [R]
Triptorelin and Central Precocious Puberty
Central precocious puberty is a condition that causes early sexual development in girls and boys. Children with this condition may be shorter than their peers as adults. They may also experience social and emotional problems, including self-esteem issues. [R]
The FDA has approved it in a 6-month formulation for the treatment of CPP. This approval came on the heels of a phase-3 clinical trial that demonstrated it may have the potential to return LH to its prepubertal levels in 93% of patients. The suppression was maintained at 12 months in 96% of patients. [R]
Triptorelin and Endometriosis
Endometriosis is a condition in which tissue similar to the one lining the womb starts growing in other places, such as the fallopian tubes and ovaries. Unfortunately, the causes of endometriosis are still unknown, even though this condition can affect women of any age.
A 1996 study evaluated the efficacy and adverse effects of monthly administration for the potential treatment of endometriosis. The study included 45 women with this condition. Results from the study show that pain-related symptoms may have decreased in all cases after 8-week treatment. [R]
In another piece of clinical research, 465 female subjects with endometriosis were administered Triptorelin. All of them reported heavy menstrual bleeding. Six months after the end of treatment, there was a significant potential improvement from baseline in the severity of heavy menstrual bleeding in 84.2% (390/463) of women. [R]
Triptorelin and Fertility
In a prospective observational study, the administration of Triptorelin was associated with potential spontaneous pregnancy in infertile adenomyosis patients. Of the forty-five patients who completed the treatment and the six months follow-up, twelve cases were pregnant during the follow-up. [R]
Triptorelin Side Effects
Side effects in research subjects may include headache, constipation, heartburn, constipation, and decreased sexual ability or desire. PureRawz does not sell Triptorelin for human consumption.
Where to Buy Triptorelin?
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Triptorelin is an FDA-approved potential treatment for advanced or metastatic prostate cancer. The FDA has also approved Triptorelin for potential endometriosis treatment. In the EU, Triptorelin has been approved as a potential breast cancer treatment in female subjects at a high risk of recurrence.
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