Uridine (Liquid) – Product Details

Uridine is one of four building blocks of RNA. Research has shown that Uridine may have the potential to decrease depressive symptoms in adolescents with bipolar disorder.

This substance may also potentially enhance cholinergic brain function and increases fat build-up in the limbs of HIV-infected patients.

An analysis has revealed that Uridine enhances neurite growth, essential for the development and regeneration of the nervous system. This research chemical can also potentially improve learning and memory and reduce inflammation in animal and human cells. [R]

Pure Rawz sells Uridine for laboratory and research purposes only.

Uridine
CAS Number	58-96-8
Molar Mass	244,2 g/mol
Chemical Formula	C9H12N2O6
IUPAC Name	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

 

What Is Uridine?

Uridine is a naturally occurring pyrimidine nucleoside. It is one of five standard nucleosides that make up nucleic acids and one of four building blocks of RNA. In humans, Uridine is present in the blood and cerebrospinal fluid. In nature, Uridine can be found in broccoli. [R]

As part of the RNA, Uridine helps translate the DNA code. The uridine present in plasma, meanwhile, aids the body in breaking down sugar for energy.

It also plays a vital role in maintaining cellular function, as well as boosting the release of dopamine in the brain. [R] [R ][R]

This nucleoside can potentially also increase CDP-choline levels in the human brain, indirectly improving cognitive function. Aside from that, it may also have the ability to activate P2Y2 receptors in the brain. P2Y2 receptors stimulate the release of nitric oxide, which plays a crucial role in learning and memory. [R]

 

How does Uridine Work?

Here are the mechanisms of action of Uridine:

 

1. May Potentially Increases CDP Choline Levels

An animal study shows that Uridine enhances the synthesis of CDP choline in the brain. CDP choline is the immediate precursor of phosphatidylcholine (PC), which, in turn, improves cognitive functions by increasing acetylcholine production. [R]

 

2. Boosts Neurite Growth

Four days of Uridine treatment produce a potential dose-dependent increase in neurite growth, per a systematic analysis. Neurites are projections from the cell body of a neuron. Their growth is critical for the development and regeneration of the nervous system. [R]

 

3. Activates P2Y2 Receptors

Results obtained from an animal study show that Uridine may potentially activate P2Y2 receptors in the brain. P2Y2 receptors play an important role in prostaglandins, nitric oxide, and acetylcholine production. All three substances play multiple crucial roles in the brain and body. [R]

 

Uridine Research

Various animal studies have been conducted to determine the potential effects of Uridine. This choline enhancer has also undergone multiple clinical trials. All these Uridine studies suggest that this nucleoside holds immense potential to enhance cognitive and physical health.

 

1. Uridine and Learning & Memory

In an animal study, dietary Uridine enhanced the improvement in learning and memory produced by administering DHA to gerbils. These data show that DHA, choline, and Uridine dietary supplement can potentially significantly improve cognitive performance. [R]

A systematic analysis of multiple studies reached the same conclusion. The analysis found that long-term exposure to increased Uridine can have thepotential ability to improve certain types of memory functions. It also determined that Uridine is as effective as CDP-choline in alleviating memory dysfunction. [R]

Finally, data from an animal study suggest that Uridine administration for five consecutive days prevented sleep deprivation-induced deficits in learning and memory in the hippocampus. [R]

 

2. Uridine and Brain Health

As part of a randomized controlled trial, a multi-nutrient enriched with Uridine, choline, and DHA slowed brain atrophy and improved some measures of cognition in individuals experiencing mild cognitive impairment (MCI) due to Alzheimer’s disease (AD). [R]

Based on the available clinical evidence, nutritional intervention should be considered as a part of the approach to the management of individuals with MCI due to AD.

 

3. Uridine and Nerve Pain

In a study involving 212 persons with peripheral neuropathy, a combination of Uridine, Vitamin B12, and folic acid significantly lowered the intensity of pain. Aside from that, the trio’s mixture also reduced the number of areas affected by the disease. [R]

A double-blind, randomized comparative study reached the same conclusion. Researchers conducting this study noted that the combination of Vitamin B12, Uridine, and Cytidine may reduce nerve pain with only mild side effects. The combination was also deemed safe. [R]

 

4. Uridine and Depression

In a study involving seven adolescents with bipolar disorder, Uridine treatment was associated with potential decrease in depressive symptoms. Participants received 500 mg Uridine monophosphate dosage twice daily for six weeks. The dose was well-tolerated. [R]

However, in a phase 2b clinical trial involving adults with bipolar disorder, oral Uridine wasn’t able to produce a statistically significant improvement in the symptoms of depression.

 

5. Uridine and Lung Diseases

The combination of Uridine triphosphate (UTP) and another compound improved breathing and cleared mucus in 14 patients with cystic fibrosis, a disease in which the lungs become damaged. The combination of the two also restored compound function to almost normal levels. [R]

It isn’t only in people with cystic fibrosis that Uridine clears mucus. In three separate studies, this nucleoside showed the potential to clear mucus in healthy people, in patients with chronic mild bronchitis, and in 12 patients with primary ciliary dyskinesia, a genetic disease. [R] [R] [R]

 

6. Uridine and HIV

Antiretroviral medications help control the infection in HIV-positive patients. But these compounds cause significant fat loss in multiple body parts over the long term. A 24-week study involving 165 HIV-infected patients showed that Uridine supplementation for 6 months may potentially increased limb fat. [R]

Taking antiretroviral drugs for an extended time period might also damage the mitochondria. One human study has shown how Uridine could potentially prevent antiretrovirals from damaging mitochondria. Multiple cell studies have also shown the same. [R] [R]

 

7. Uridine and Dry Eye Syndrome

Dry eye syndrome affects 20 percent of adults, decreasing the production of tears and casing inflammation on the eye’s surface.

In a randomized, double-blind, 3-month controlled prospective clinical study, oral Uridine was administered to 27 patients with dry eyes. Results obtained from the study show that this nucleoside could potentially be an effective treatment for dry eyes. [R]

 

8. Uridine and Sleep

A 1984 study established a clear-cut link between Uridine and the onset of sleep. It showed that intraventricular infusion of Uridine may significantly increase sleep in rats during the dark environmental period. Slow wave sleep (SWS) and paradoxical sleep (PS) both increased. [R]

Thirty infants with disordered sleep experienced improved sleep quality after they were administered a cereal containing uridine-5′-phosphate, tryptophan, and adenosine-5′-phosphate. Uridine-5′-phosphate is a chemical compound derived from phosphoric acid and Uridine. [R]

 

Where to Buy Uridine Monophosphate?

Pure Rawz is the best place to buy nucleoside Uridine for sale.

In order to be the best supplier of tissue-selective research drugs, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

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Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABRATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB).

All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

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