VIP (Vasoactive Intestinal Peptide)

Description

Vasoactive Intestinal Peptide

Vasoactive Intestinal Peptide (VIP) is a 28–amino acid neuropeptide. It is found across different biological systems and cellular environments. In research settings, it is mainly examined for how it interacts with specific peptide receptors and participates in intracellular signaling processes.

More specifically, studies look at VIP as a ligand in receptor-mediated pathways. This is particularly associated with cyclic adenosine monophosphate (cAMP) signaling. Because of its structure, it has been shown to bind to class B G protein-coupled receptors, particularly VPAC1 and VPAC2. This way, it continues to be explored in molecular signaling research.

Chemical and Molecular Properties

Property	Details
Pubchem ID	CID 53314964
Molecular Formula	C147H237N43O43S
Molecular Weight	3326.8 g/mol
Synonyms	Vasoactive Intestinal Peptide; VIP; His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn; UNII-6J2WVD66KR; CCRIS 7231; VIP [MI]’ Vasoactive intestinal peptide, synthetic porcine; SCHEMBL30969141
IUPAC Name	Not commonly assigned due to peptide complexity; defined by full amino acid sequence
CAS Number	37221-79-7
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity Percentage (%)	≥98%
Stability / Shelf Life	Stability is dependent on controlled laboratory storage conditions; peptide integrity may vary with exposure to heat, light, and moisture
Storage Instructions	Store under frozen conditions (commonly -30°C to -60°C) to preserve structural stability

Working Mechanism of Vasoactive Intestinal Peptide

Vasoactive Intestinal Peptide is primarily studied for how it engages with receptor systems and initiates intracellular signaling cascades. These are explored in controlled environments to better understand peptide-receptor interactions at the molecular level. Moreover:

• It has been shown to interact with VPAC1 and VPAC2 receptors, both part of the G protein-coupled receptor (GPCR) family
• VIP has been studied to activate adenylate cyclase following receptor binding, leading to increased intracellular cAMP levels in experimental models.
• Studies suggest activation of protein kinase A (PKA)-dependent signaling pathways downstream of cAMP production.
• It has been studied for its role in modulating ion channel activity and intracellular calcium signaling through secondary messengers
• It has been associated with transcription-related pathways via cAMP response element-binding protein (CREB) signaling

Why Choose Purerawz for Vasoactive Intestinal Peptide?

Buy Vasoactive Intestinal Peptide for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Vasoactive Intestinal Peptide is an investigational compound. It is not established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

Reference Links

PubChem. (2025). Vasoactive Intestinal Peptide. Pubchem.ncbi.nlm.nih.gov. https://pubchem.ncbi.nlm.nih.gov/compound/53314964 

Grant, S. M., Lutz, E. M., McPhaden, A. R., & Wadsworth, R. M. (2006). Location and function of VIP receptors in vascular signaling models. PubMed; National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/15959462/ 

National Center for Biotechnology Information. (2002). Vasoactive Intestinal Peptide receptor pharmacophore study. PubMed. https://pubmed.ncbi.nlm.nih.gov/12388623/ 

‌National Center for Biotechnology Information. (2019). Recent advances in vasoactive intestinal peptide physiology and pathophysiology. PubMed Central (PMC). https://pmc.ncbi.nlm.nih.gov/articles/PMC6743256/

PubChem. (2026). Vasoactive intestinal peptide SMILES and structural data. Pubchem.ncbi.nlm.nih.gov. https://pubchem.ncbi.nlm.nih.gov/compound/Vasoactive-intestinal-peptide#section=SMILES