YK11 primarily works by inhibiting myostatin.

Myostatin is a protein naturally produced by muscle cells in the human body. This protein plays a crucial role in muscle movement and impedes muscle growth and strength, ensuring that muscles do not get too large to inhibit their movement. [R]

A cell study has found that YK11 inhibits myostatin by raising the levels of follistatin. Follistatin is another naturally occurring protein in the human body. Its elevated levels have been proven to keep myostatin levels in check, helping muscles grow and strengthen. [R] [R]

Is YK11 A SARM?

YK11 is a selective androgen receptor modulator, but it is also something more. This research compound acts similarly to SARMs in that it binds androgen receptors in the muscle and bone tissue. However, unlike SARMs, it also inhibits myostatin, the naturally occurring protein that impedes muscle growth.

Furthermore, while the majority of SARMs are full agonists of androgen receptors, YK11 has been found to be a partial agonist. Yet another difference between YK11 and SARMs is that it is a steroidal compound, whereas most SARMs tend to be non-steroidal.

YK11 Research

While various cell studies have been conducted on YK11, this steroidal SARM is yet to attract any human or even animal studies. The available clinical data is thus insufficient to claim that it is safe for human consumption. Randomized long-term trials are needed to determine its safety and efficacy.

1. YK11 and Muscle Mass

Myostatin is a protein that impedes muscle growth and strengthening.

A cell study has shown that YK11 attaches to the androgen receptor to help inhibit the production of myostatin in the muscle to create more follistatin, thus, increasing muscle growth. This shows massive promise in the potential anabolic activity of YK11. [R]

The mechanism with which YK11 works distinguishes it from other SARMs. Most SARMs work by binding androgen receptors in the muscle and bone tissue. They don’t have anything to do with myostatin or follistatin. YK11 is thus a novel steroidal SARM.

2. YK11 and Bones

In a cell study, YK11 was found to activate PKB (protein kinase B) in osteoblast cells of mice.

PKB are enzymes naturally found in the human body. Research has shown that, upon, activation, PKBs send signals to stimulate bone growth. They are also proven to play an essential role in glucose metabolism as well as angiogenesis. [R]

However, more extensive research and randomized trials are needed to potentially evaluate its efficacy in strengthening bones in select populations.

3. YK11 and Muscle Wasting

Sepsis patients are especially vulnerable to muscle wasting.

To observe the effects of YK11 on muscle wasting, septic mice were administered Myostatin. YK11 was found to decrease weight loss in the mice in a concentration-dependent manner. YK11 also reverted muscle mass loss and muscle cell atrophy, and increased total body weight. [R]

Moreover, YK11 uptake helped recover the muscle mass loss in the backs and thighs of mice. Still, longer randomized trials are needed to evaluate its efficacy in select populations.

4. YK11 and Fat Loss

A recent study set out to investigate the expression and regulation of myostatin in skeletal muscle in septic mice. The results showed that YK11 treatment decreased fat mass. [R]

However, in the absence of any long-term study, it is difficult to verify the effect of YK11 on fat mass in select populations. Long-term, clinical trials are needed to potentially evaluate its efficacy in reducing body fat.

YK11 FAQs

Is YK11 Legal in the USA?

YK11 is legal to purchase a research compound.

Like other SARMs, it can be used for laboratory research use only.

Does YK11 Help With Weight Loss?

No. YK11 was found to decrease weight loss in the mice in a concentration-dependent manner, i.e. total body weight of the mice recovered better or increased with increasing concentration of this research compound.

Is YK11 A Steroid?

YK11 doesn’t belong to the anabolic steroids family. It is a synthetic steroidal SARM that selectively binds androgen receptors in the bone and muscle tissue. Aside from that, YK11 may also inhibit myostatin, a hormone that impedes rapid muscle growth in animals and humans.

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YK11 Summary

YK 11 is a synthetic steroid SARM that may increase muscle mass and enhance bone health, per preliminary cell studies. However, long-term randomized clinical trials are needed to verify its safety and efficacy in random populations.