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Sulbutiamine – Product Information

Sulbutiamine is a synthetic thiamine (vitamin B1) derivative composed of two modified thiamine molecules that form a dimer.

It is highly lipophilic, allowing it to potentially easily cross the blood-brain barrier compared to other thiamine derivatives.

CAS Number 3286-46-2
Molar Mass 702.89 g/mol
Chemical Formula C32H46N8O6S2
IUPAC Name [4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl-amino]-3-[2-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl-amino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanyl-pent-3-enyl] 2-methylpropanoate

What is Sulbutiamine?

Sulbutiamine is a man-made chemical similar to vitamin B1 (thiamine).

However, Sulbutiamine, unlike vitamin B1, dissolves in fats rather than water.

Sulbutiamine can raise thiamine levels in the brain, which gives it the potential to address thiamine deficiency. It is also believed to have mild stimulant properties.

The only antiasthenic compound known to cross the blood-brain barrier, Sulbutiamine is a highly lipophilic thiamine derivative.

In December 2019, the United States Sulbutiamine was added to the Dietary Supplement Ingredient Advisory List by the Food and Drug Administration. The ingredients on this list may be illegal to use in dietary supplements. As a result, people should avoid taking Sulbutiamine capsules.

If you buy Sulbutiamine, available online, it should only be used for research purposes and not for human consumption.

Potential Applications of Sulbutiamine?

Several kinds of research have been done to study Sulbutiamine’s capability to become a chronic treatment for certain illnesses or medical conditions. Nevertheless, these studies still need more convincing results.

Here are some of the known advantages of Sulbutiamine according to reliable clinical studies:

Sulbutiamine and Fatigue

Sulbutiamine (along with anti-infective treatment) improved energy levels in a study of 1,772 patients with infections and chronic fatigue. According to the research, fifty-two percent of patients reported a significant improvement in mood and energy. [R]

Sulbutiamine capsules have reduced fatigue by 44% among 341 who are experiencing chronic postinfectious fatigue. But a concern for this study is that it lacked a placebo control. [R]

Sulbutiamine treatment (400 mg daily for 1 month) significantly improved symptoms of severe depression, anxiety, and fatigue in most patients (75%), according to another uncontrolled study of 40 participants. [R]

IMPORTANT: Despite the findings of the previous studies, larger, well-designed clinical trials are required to confirm the therapeutic effects of Sulbutiamine for fatigue. For this reason, you should not interpret them as indicative of any health advantage for humans.

Sulbutiamine and Diabetic Neuropathy

High blood sugar levels can cause diabetes-related nerve damage, which could lead to serious health conditions. A clinical study for a 6-week Sulbutiamine use (400 mg daily) shows improved nerve and muscle function in 15 diabetic patients. [R]

Sulbutiamine and Indigestion

This potential application is based on a 33-patient study. Following kidney surgery, taking Sulbutiamine capsules restored digestion. The clinically tested fat-soluble supplement also significantly improved gut flow in tissue studies, but the clinical significance of this effect is still unknown. [R]

Sulbutiamine and Erectile Dysfunction

Sulbutiamine treatment for 30 days allegedly restored sexual performance in 16 of 20 erectile dysfunction patients. However, this study lacked a placebo control which should be a significant factor. [R]

Sulbutiamine and Memory Improvement

In a study of 26 Alzheimer’s patients, Sulbutiamine combined with donepezil improved memory. [R]

Sulbutiamine improved long-term memory formation based on a study concerning rat brains.

This is due to increased neurotransmitters (such as choline), which may improve memory retention and mental clarity. It is as if you have been stimulated by caffeine-based drinks.

Sulbutiamine and Depression

A multicentric, randomized, double-blind, placebo-controlled trial suggests Sulbutiamine’s effect on major depressive disorder.

The synthetic chemical has no antidepressant effect but can hasten the resorption of psycho-behavioral inhibition that occurs during major depressive disorder.

This outcome could allow patients to be more functional in their social, professional, and family lives. [R]

Sulbutiamine and Neurons

According to one study, nutrient-deprived brain cells treated with Sulbutiamine lived significantly longer than cells that did not receive the drug. [R]

Sulbutiamine also increased the lifespan of brain cells experiencing oxygen-glucose deprivation. It also increased activity in the part of the brain responsible for memory formation (hippocampus). [R]

Sulbutiamine and Antioxidant Effects

Treatment with Sulbutiamine may also increase the activity of antioxidant enzymes (GSH) in cells while decreasing harmful compounds (ROS) levels. This is the conclusion of researchers who study the nootropic under consideration. [R]

How Does Sulbutiamine Work?

Japanese researchers in the 1960s developed Sulbutiamine. These scientists study thiamine looking for a treatment for its deficiency. Sulbutiamine is synthesized by combining two thiamine (vitamin B1) molecules.

Because the chemical is more fat-soluble than thiamine, Sulbutiamine crosses the blood-brain barrier easily. [R]

Sulbutiamine boosts thiamine levels in the brain more than other types of thiamine. [R]

Below is a list of Sulbutiamine’s mechanisms of action that could affect certain biological processes:

  • It may promote mental health by altering glutamate’s action toward dopamine. [R]
  • It may boost the brain’s energy usage by increasing levels of thiamine triphosphate. [R]
  • It may help in the formation of memory through the increase of vital activity in the hippocampus. [R]

Frequently Asked Questions

Is Sulbutiamine safe?

Sulbutiamine is still considered a highly researched compound which means it cannot be used for human consumption or as a cure to treat the human body. Although the chemical has potential benefits, purchase Sulbutiamine capsules for research purposes only.

What are other names for Sulbutiamine?

Arcalion, Enerion, Bisibuthiamine, and Youvitan are all brand names for Sulbutiamine. Sulbutiamine is not to be confused with Sibutramine, a pharmaceutical appetite suppressant.

Can you stack Sulbutiamine?

Sulbutiamine is known to work well with the following research chemicals in clinical settings:


What is Sulbutiamine’s common form?

Sulbutiamine may come in powder form or they may be availed in capsules. PureRawz offers Sulbutiamine powder in three variants: 10g, 20g, and 50g.

Where can you buy Sulbutiamine online?

Today Sulbutiamine is available from different vendors online. PureRawz is the best place to buy high-quality Vinpocetine online. We even accept international orders.

You may also see the reviews on our Sulbutiamine, where our customers share their experience with our research chemicals.

In order to be the best supplier of research peptides, we provide additional information (such as reference materials) with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.
All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

9 reviews for Sulbutiamine

  1. Anonymous (verified owner)

    It works I have more mental stamina and able to stay up for longer but the only downside is that it has a weird smell to it so is best to get it in caps or tab form.

  2. Derrick Markunson

    This works amazing , I am very pleased with the product .

  3. Dean

    Great one, really helped with my concentration while doing my exams.

  4. Jeremy

    I just wanted to say that this really enhances cognitive functions.

  5. Noel S.


  6. Milford Gorczany

    I love it! Very affordable and always available on your end. Thanks

  7. Jacob Cole

    Excellent product. Worth every single penny

  8. WH Greenfelder

    Thank you so much for this. High quality ingredients. Definitely feeling a good lift in my mood and brain functions.

  9. carljimmy

    Consistent and powerful effects.

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