Andarine (S-4) – Product Details
Andarine, also known as S-4 or GTx-007, is a selective androgen receptor modulator (SARM). A scientific study published in 2005 examined the effects of Andarine S-4 on the skeletal muscles, bones, and pituitary glands of castrated male rats. A treatment protocol (3 and 10mg/kg S4- Andarine for 8 weeks) was commenced 12 weeks after castration. Andarine (doses 3 and 10 mg/kg) restored soleus muscle mass and strength and levator ani muscle mass to that seen prior to castration or in intact animals.
In another animal study, the osteoanabolic activities of it were compared with that of dihydrotestosterone (DHT). When S-4 was administered to ovariectomized rats for 4 weeks, their femur bone mineral density and levator ani muscle weight were increased as markedly as DHT. However, prostate weight was not elevated over the normal at any doses tested.
This makes S4 an investigational Selective androgen receptor modulator for the possible treatment of conditions related to muscle wasting, osteoporosis, and benign prostatic hypertrophy (BPH). It has the ability to mimic many of the beneficial pharmacologic effects associated with testosterone.
How Does Andarine Work?
Andarine works by targeting androgen receptors (ARs) on a tissue-selective basis. It mainly binds ARs in the muscle and bone tissue, sparing the reproductive organs. This distinguishes it from Testosterone and anabolic steroids, whose effects arenât as limited.
An animal study published in 2003 confirmed this. It was set out to examine the in vitro and in vivo pharmacological activity of Andarine and other SARMs. The study found that the activities of S-4 were tissue-selective in that it stimulated the anabolic organs more than the androgenic organs.
While Andarine S-4 was less potent and efficacious than testosterone in androgenic activity, its anabolic activity was similar to or greater than that of testosterone. Also, it didnât cause significant luteinizing hormone or follicle-stimulating hormone suppression at doses near the ED (50) value. [R]
Andarine has been subjected to various animal studies. Almost all of them involved rats. That means that the available clinical data is insufficient to claim that it is safe for human consumption. Long-term, randomized clinical trials are needed to verify its safety and efficacy.
Andarine and Muscle Mass
Andarine was developed to treat conditions such as muscle wasting.
A recent study set out to investigate the bone anabolic effects of Andarine. The compound was administered to ovariectomized rats for 4 weeks. It was found that the muscle weight of levator ani was increased as markedly as DHT. But the prostate weight was not elevated over the norm. [R]
Another study showed similar results. Twelve weeks after castration, ovariectomized rats were administered 3 or 10mg/kg of it or 3mg/kg of DHT for 8 weeks. It restored soleus muscle mass and strength and levator ani muscle mass to that seen in intact animals. [R]
Andarine and Bone Density
In an animal study, the effects of S-4 treatment in osteopenic female rats were noted. Significant increases in cortical bone quality were observed at the femoral midshaft, resulting in increased load-bearing capacity. S-4 also demonstrated partial/total recovery of bone parameters to age-matched intact levels.
In a separate study, S-4 treatment prevented bone loss in ovariectomized rats, while in another rat study, Andarine treatment caused a significantly larger increase in bone mineral density than DHT. All these studies show massive promise in the potential bone strength increase brought on by Andarine. [R]
Andarine and Fat Loss
A study was conducted to examine the bone and body composition effects of It in ovariectomized rats. It was found that the S-4 treatment decreased body fat in these animals while increasing bone strength. [R]
More extensive research and randomized trials are needed to potentially evaluate this SARMâs efficacy in inducing fat loss in select populations.
Is Andarine A Effective SARM?
An animal study has shown that this SARM treatment improves muscle strength and body composition and prevents bone loss in ovariectomized rats. All these effects were achieved with minimal pharmacologic effects in the prostate. [R]
Is Andarine Legal?
It is legal to purchase as a research compound.
Like other SARMs, it can be used for laboratory research use only.
What Is The Half-Life of Andarine S-4?
Andarine S-4 has a short half-life of 4 hours.
Where to Buy Andarine Online
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It was developed to treat conditions such as muscle wasting, osteoporosis, and benign prostatic hypertrophy (weakening of the prostate gland).
Multiple animal studies have shown that it possesses potential muscle and bone anabolic effects. Aside from that, in at least one rat study, this compound caused fat loss. Still, long-term randomized clinical trials are needed to verify this compoundâs efficacy and safety.