What is Mirodenafil?

As the first-line therapy for erectile dysfunction, it is a member of the group of medications known as PDE5 inhibitors, which also includes avanafil, sildenafil, tadalafil, udenafil, and vardenafil.

How does Mirodenafil work?

Nitric oxide (NO) is released during sexual arousal by endothelial cells and nerve terminals in the corpus cavernosum. A cGMP-dependent chain of actions is started when NO stimulates guanylate cyclase to change guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). The buildup of cGMP causes the corpus cavernosum’s smooth muscles to relax and the blood flow to the penis to increase.

PDE5 is an enzyme that specifically cleaves and degrades cGMP to 5′-GMP in the corpus cavernosum smooth muscle. PDE5 inhibitors have a structure that is comparable to that of cGMP; they bind to PDE5 competitively and prevent cGMP hydrolysis, which improves the effects of NO. The lengthening of an erection is caused by an increase in cGMP in smooth muscle cells.

The relaxation of corpus cavernosum smooth muscles is not directly impacted by PDE5 inhibitors. Therefore, for an erection to occur after potential ingestion, there must be sufficient sexual stimulation. [R]

Purerawz does not sell Mirodenafil for human use or consumption.

Mirodenafil Research

Mirodenafil and Erectile Dysfunction

The pharmacokinetic properties of it have been compared with those of sildenafil in rats. Results found that rats’ corpus cavernosum concentration peaked at 2,812 ng/mL and 1,116 ng/mL at 1.4 hours following a dose, respectively, and then began to decline with a t1/2 of 1.3 and 0.9 hours. In the plasma and corpus cavernosum tissue, mirodenafil’s Cmax and AUC were substantially higher than those of sildenafil. [R]

Additionally, the corpus cavernosum relaxes in response to mirodenafil in a dose-dependent way, as was revealed by its influence of it on tissue relaxation in rabbit model organ bath research. [R]

Erectile Dysfunction and Spinal Cord Injury

PDE5 inhibitors, particularly sildenafil, may be the first-line treatment for ED in patients with spinal cord injuries, according to a number of studies. [R]

In clinical practice, it is challenging to differentiate between the PDE5 inhibitors and to give specific patient advice. There is only one experimental investigation on mirodenafil that is accessible.

It dramatically increased erectile function in a rabbit model of acute spinal cord injury, and its effectiveness was superior to sildenafil in terms of the peak length of the penile mucosa and the start time of action. [R]

Mirodenafil and Premature Ejaculation

In patients with premature ejaculation (PE) without ED, a study on the use of mirodenafil and dapoxetine has been released. When compared to dapoxetine alone, the combination of mirodenafil and dapoxetine produced better effects in terms of intravaginal ejaculatory delay time and PE profile index score, as well as equivalent treatment-emergent side events. [R]

Mirodenafil and Lower Urinary Tract Symptoms (LUTS)

As people get older, they are more likely to have ED and LUTS related to Benign Prostatic Hyperplasia (BPH). Clinical data demonstrate a shared etiology between ED and LUTS brought on by BPH. [R]

Pharmacotherapy with 5-reductase inhibitors or 1-adrenergic blockers is the first-line treatment for BPH-LUTS. When there is a considerable enlargement of the prostate gland, the latter is recommended.

Three studies concerning the use of mirodenafil in LUTS are included in the current literature – two on the combination of mirodenafil with α1-blockers and one on mirodenafil vs. placebo.

According to the findings of these three studies, using mirodenafil to treat LUTS patients has a considerable positive impact on both LUTS and erectile function in men with BPH. Patients with LUTS owing to BPH with ED may benefit from taking mirodenafil, according to some research. Long-term consequences will need to be determined by additional research, and the efficacy will need to be further evaluated in a large-scale study. [R]

FAQs

Mirodenafil vs Sildenafil

While the pharmacokinetic profile is similar to that of sildenafil, it appears to be 10 times more selective for PDE5 than sildenafil. [R]

Is Mirodenafil Safe?

In males with both ED and hypertension or lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia, it appears to be efficacious, safe, and well tolerated. [R]

Purerawz sells Mirodenafil for research use only.

Where to Buy Mirodenafil Online

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