PT-141 + Oxytocin

Description

What is PT-141 + Oxytocin Nasal Spray?

Researchers study the combination of PT-141 and Oxytocin nasal spray in laboratory environments to learn their synergistic potential outcomes.Studies have explored that the combination may offer a convenient approach for research exploring behavioral motivation pathways, affiliative signaling mechanisms, and stress-response regulation.

What is PT-141?

Bremelanotide, formerly PT-141, is a synthetic alpha-MSH peptide analog. Researchers believe that PT-141 may modulate intake-related regulation, metabolic maintenance processes, and general signaling pathways.

The cyclic heptapeptide structure of PT-141 makes it stable and bioactive, affecting several receptors.

Chemical Properties

PT-141
CAS	189691-06-3
Molar Mass	1025.182 g/mol
Chemical Formula	C50H68N14O10
IUPAC Name	(3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid

How does PT-141 or bremelanotide work?

Researchers have suggested that PT-141 may works by activating specific melanocortin receptors- namely, MC1R, MC3R, and MC4R- in research models.

Research using PT-141 administration in preclinical models has shown that it may stimulate these receptors and trigger peripheral vascular responses. This hypothalamic activation highlights the role of melanocortin receptors in neuroendocrine regulatory pathways in strict laboratory research models.

Potential Research Application of PT-141 

PT-141 is being investigated for its role in melanocortin receptor signaling and associated neurochemical pathways.It is examined for its interaction with central melanocortin systems and related neuroendocrine signaling processes.

What is Oxytocin?

Oxytocin is a peptide. It is commonly studied in research settings for its role in neuroendocrine signaling and receptor-mediated processes.

Oxytocin
CAS	50-56-6
Molar M	1007.19 g/mol
Chemical Formula	C43H66N12O12S2
IUPAC Name	1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide

Research Applications of Oxytocin

Oxytocin is studied for peptide receptor interaction mechanisms and ligand binding dynamics in controlled research settings.
It is investigated for its role in cellular signaling pathways and molecular communication processes. The peptide is used in laboratory studies to examine signal transduction and receptor activation patterns. Applied in research focused on peptide structure, stability, and receptor affinity characteristics.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All preclinical research must be conducted with oversight from the relevant Institutional Animal Care and Use Committee (IACUC), following the Animal Welfare Act (AWA) guidelines.

Our content is intended to be used and must be used for informational purposes only.

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Reference Links 

MOLINOFF, P. B., SHADIACK, A. M., EARLE, D., DIAMOND, L. E., & QUON, C. Y. (2003). PT-141: A Melanocortin Agonist for the Treatment of Sexual Dysfunction. Annals of the New York Academy of Sciences, 994(1), 96–102. https://doi.org/10.1111/j.1749-6632.2003.tb03167.x

Oxytocin: What It Is, Function & Effects. (2022, March 27). Cleveland Clinic. https://my.clevelandclinic.org/health/articles/22618-oxytocin

LeWine, H. (2023, June 13). Oxytocin: The love hormone. Harvard Health; Harvard Health Publishing. https://www.health.harvard.edu/mind-and-mood/oxytocin-the-love-hormone