Deslorelin

Deslorelin is a synthetic peptide analog derived from gonadotropin‑releasing hormone (GnRH), a regulatory neuropeptide involved in endocrine signaling pathways. Deslorelin is structurally altered compared to typical GnRH, featuring changes that improve receptor binding affinity and metabolic stability in experimental contexts. Because of these modifications, deslorelin is widely examined in molecular endocrinology and receptor signaling research.

Deslorelin is classified as an investigational research compound and is supplied strictly for laboratory research applications.

Chemical and Molecular Properties 

Deslorelin
PubChem CID	25077495
Molecular Formula	C64H83N17O12
Molecular Weight	1282.4 g/mol
Synonyms	D-Trp LHRH-PEA Deslorelina Desloreline
IUPAC	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS	57773-65-6
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Research Use Only (RUO)
Storage Temperature	Store at −20 °C in a dry, light-protected environment
Solubility	Soluble in research‑grade aqueous buffers or DMSO
Safety	Use gloves, lab coat, and eye protection; handle in fume hood if dust/aerosol is possible

Deslorelin Mechanism 

GnRH Receptor Interaction

Deslorelin functions as a high‑affinity agonist of the gonadotropin‑releasing hormone receptor (GnRHR), a member of the G protein‑coupled receptor (GPCR) family. In experimental cellular systems, binding of deslorelin to GnRHR initiates receptor conformational changes that activate intracellular signaling pathways mediated by G proteins. These interactions are typically examined in receptor‑binding assays and cultured cell models to evaluate ligand‑receptor dynamics and signaling kinetics.

Activation of Phospholipase C Signaling

Upon receptor activation, GnRHR signaling has been shown in in vitro studies to stimulate phospholipase C (PLC) activity. PLC catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), producing intracellular second messengers such as inositol trisphosphate (IP3) and diacylglycerol (DAG). These signaling molecules participate in downstream regulatory processes, including intracellular calcium mobilization and protein kinase C activation.

Receptor Desensitization and Signal Modulation

Deslorelin and other synthetic GnRH analogs have been studied for receptor desensitization in test subjects. Internalization, or regulatory feedback loops, can change receptor signaling efficiency with continuous stimulation. These processes are examined in preclinical and molecular research models to understand the dynamics of GPCR signaling regulation.

Gene Expression and Cellular Signaling Pathways

Research models have also explored how GnRH receptor activation influences transcriptional regulatory pathways. In vitro studies demonstrate that GnRH agonists may activate signaling networks involving mitogen-activated protein kinases (MAPK) and other intracellular regulatory proteins. These molecular pathways are analyzed to understand the broader cellular responses associated with peptide‑receptor signaling.

Research Applications of Deslorelin

Deslorelin is utilized in laboratory environments as a research tool for investigating endocrine signaling mechanisms and peptide receptor pharmacology. In experimental settings, it has been examined in studies involving:

• GnRH receptor binding and activation assays
• G protein‑coupled receptor signaling pathways
• Intracellular second messenger systems such as IP3 and DAG
• Regulatory feedback mechanisms in endocrine signaling networks
• Cellular signaling pathways involving MAPK and protein kinase activation

Because of its enhanced receptor affinity and stability compared with native GnRH, deslorelin provides a useful molecular probe for experimental models investigating neuroendocrine communication and receptor pharmacology.

Why Choose Purerawz for Deslorelin?

Buy Deslorelin for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Deslorelin is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

Conn, P. M., & Crowley, W. F. (1991). Gonadotropin‑releasing hormone and its analogs. New England Journal of Medicine, 324(2), 93–103. https://pubmed.ncbi.nlm.nih.gov/8198390/ 

Millar, R. P., Lu, Z. L., Pawson, A. J., Flanagan, C. A., Morgan, K., & Maudsley, S. (2004). Gonadotropin‑releasing hormone receptors. Endocrine Reviews, 25(2), 235–275. https://pubmed.ncbi.nlm.nih.gov/15082521/ 

Karten, M. J., & Rivier, J. E. (1986). Gonadotropin‑releasing hormone analog design: structure‑function studies toward the development of agonists and antagonists. Endocrine Reviews, 7(1), 44–66. https://pubmed.ncbi.nlm.nih.gov/2420580/ 

PubChem Compound Summary for Deslorelin. National Center for Biotechnology Information, U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/deslorelin