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Evodiamine – Product Information

CAS Number 518-17-2
Molar Mass 480.63 g/mol
Chemical Formula C19H17N3O
IUPAC Name 21-Methyl-3,13,21-triazapentacyclo[,10.04,9.015,20]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one

What is Evodiamine?

The plant Evodiae fructus is the source of the bioactive alkaloid (a naturally occurring amino produced by a plant) extract known as evodiamine. Commonly abbreviated as EVO, evodiamine is a stimulant that raises the body heat and resting core temperature.

Chinese herbalists use evodiamine, also referred to as Wu-Chu-Yu, to aid in weight loss. Although no medical studies support this, the Chinese have used this for weight loss for thousands of years.

Additionally, it has been used to treat various digestive issues, such as poor appetite, nausea, vomiting, diarrhea, and stomach ulcers. Due to its thermogenic qualities, Chinese healers utilize it as a warming agent or “hot herb.”

The wide range of pharmacological effects of evodiamine currently suggests that it plays a crucial part in treating numerous diseases by influencing the function of numerous targets.

The FDA considers evodiamine an experimental drug meaning it should not be taken as a daily supplement. The drug still requires large-scale studies before it can be considered safe for human consumption. At Pure Rawz, we encourage our customers to buy evodiamine for research use only.

What are the Alleged Health Benefits of Evodiamine?

Evodiamine and Fat Loss

Even though evodiamine concentration hasn’t been tested on humans, take note that the results for fat loss are still encouraging. Evodiamine-treated rats in a published 2001 study showed appreciable fat loss when compared to a control group. The study’s discovery determined that evodiamine could cause heat loss while also increasing heat production was intriguing.

This data expressed that eating less leads to less fat storage and weight gain.[R]

The researchers deduced from this that evodiamine led to more effective use of food energy. According to the same study, evodiamine may efficiently promote the thermogenesis of brown adipose tissue. Thus the research drug offers a more potent fat-burning effect.

From the scientific findings above, we can safely conclude that evodiamine has effective metabolism-boosting and fat-loss properties without the fiery kick, just like its capsaicin counterpart.

Evodiamine and Inflammation

Ibuprofen is an example of an over-the-counter NSAID that prevents the pro-inflammatory enzyme COX from doing its job. Pain and swelling are reduced by reducing inflammation.

Specific research supports the use of evodiamine as a natural pain reliever because it has the capability to prevent the upregulation of COX-2. This feature is in addition to evodiamine’s warming and fat-loss advantages.

Furthermore, researchers discovered that the potent alkaloid inhibited NF-kB, a well-known marker of inflammation.[R]

Evodiamine and Cancer

Evodiamine could play a key role in treating cancer. Evodiamine inhibits cancer cell cycle distribution and induces cell apoptosis, both of which contribute to antitumor growth.

Based on the documentation of small-scale laboratory studies results, evodiamine inhibits the growth of cancer cell lines representative of the following:

  • Acute leukemia [R]
  • Malignant melanoma [R]
  • Lung cancer [R]
  • Prostate cancer [R][R][R]
  • Breast cancer [R] and
  • Cervical cancer [R]

The tests mentioned above are all in a dose- and time-dependent manner.

According to a separate study, the evodiamine substance inhibits colon carcinoma 26-L5 cells’ ability to cause lung metastases in mice by 70%. The number of tumors in those mice receiving evodiamine was significantly lower than in the control group.[R]

To determine whether EVO can be used in the adjuvant treatment of patients with clinical tumors, the availability of extensive clinical and animal studies are still needed.

Evodiamine and Digestive Issues

Several studies using male rats have focused on the effects of evodiamine on specific digestive issues. Gastric emptying, gastrointestinal transit, and plasma cholecystokinin levels (CCK) are the issues considered.[R]

According to the involved scientists, evodiamine may inhibit gastric emptying and gastrointestinal transit in male rats through a mechanism involving CCK release and CCK1 receptor activation.

However, more research is required to confirm evodiamine’s solution to the reported digestive issues.

Evodiamine and Alzheimer’s Disease

A lab experiment looked into how evodiamine affected the development of Alzheimer’s disease (AD) in transgenic mouse models. The results showed that the research chemical significantly reduced neuroinflammation and glial cell activation process, familiar in patients with AD in the hippocampus.[R]

However, additional studies are still required to confirm evodiamine’s ability to treat AD.

How does Evodiamine Work?

Evodia rutaecarpa is a very well-liked multi-purpose herb that has long been used in China to treat amenorrhea, dysentery, postpartum hemorrhage, headaches, and abdominal pain. Evodiamine is one of the main components of Evodia rutaecarpa.

A growing body of research shows that evodiamine has anti-cancer properties both in vitro and in vivo. Evodiamine increases body temperature while slowing the growth of some cancer cells. Combined with specific medications, it can also alter the metabolism and affect the release of catecholamines from the adrenal glands.

Catecholamines are crucial because they alter the human body’s physiological processes and prepare individuals for a physical response. The blood pressure, heart rate, and blood glucose levels all rise after taking evodiamine, similar to increased adrenaline levels.

Evodiamine has the same property as the red pepper extract capsaicin, a vanilloid receptor agonist. It requires three times the concentration in vitro to maximally stimulate the receptors, suggesting that it is slightly less potent than capsaicin.

Evodia rutacarpa has antinocioreceptive (pain-relieving) properties that interact with vanilloid receptors.

Does Evodiamine Come with Side Effects?

Evodiamine demonstrates a wide range of pharmacological applications, as shown above. These would include analgesic, anti-inflammatory, antitumor, anti-microbial, heart protection, and regulation of metabolic disease.

However, it has also been discovered to have significant cardiotoxicity and hepatotoxicity. As a result, it needs to be monitored in clinical settings. Furthermore, the information at hand shows that evodiamine is insoluble in water.

Frequently Asked Questions

What is evodiamine researched for?

A significant alkaloid known as evodiamine (EVO) was discovered in the dry, unripe fruit Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae). EVO has a range of pharmacological effects, including those that are neuroprotective, analgesic, antitumor, and anti-ulcerogenic.

Is evodiamine a potential stimulant?

The main effects of evodiamine are stimulant and thermogenic. Evodiamine may also work by boosting the number of serotonin transporters in the brain, improving serotonin reuptake.

Evodiamine for sale may come in powder or tablet form.

Is there any food that contains evodiamine?

No, it’s only available as a supplement and through the plant Evodiae fructus.

What are Evodiamine’s Product Details?

EVO’s chemical formula, which affects its chemical structure, is C19H17N3O, with a molecular weight of 303.37. Evodiamine is also barely soluble in aether and diluted alcohol. It is insoluble in water, benzene, and chloroform.

Can you stack evodiamine?

Evodiamine may work well in research with yohimbine.

Where can you buy Evodiamine?

Pure Rawz is the best online store to buy evodiamine. You may see our website to learn more about product details and other research chemicals similar to evodiamine. You may also contact us by sending us a message with any queries regarding our formulations.

To be the best supplier of tissue-selective research drugs, we provide reference materials with every product we sell. Our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

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This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.
All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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11 reviews for Evodiamine

  1. Casey

    I couldn’t find this anywhere! So happy that you stock this here.

  2. Evan Schoeman

    Beyond happy about this product .

  3. Nathan Daniels

    A great product for losing belly fat and love handles!

  4. Anonymous

    I suffer from Acid Reflux and have seen many doctors had examinations from the inside out top to bottom. Of all the so called remedies this one works the best…

  5. Christopher Bryant

    Always looking for an edge, this is it! Purerawz always has an awesome line of stackable products. You guys are awesome.

  6. Xavi

    Excellent customer service!

    Thank you for all your help

  7. Jason

    Finally found a real Evodiamine.

  8. John Wright

    I can highly recommend it.

  9. O.J. Upton

    Losing masses of weight!

  10. Dominik Stark

    Very happy so far, this has really been helping me keep my weight at bay.

  11. Hugo Dennis

    This helped a lot with some after-work out pain and inflammation.
    Thumbs up from me.

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