GW 0742

(5 customer reviews)

$43.48$104.48

Earn 43 - 104 points upon purchasing this product.

  • 1st and 3rd Party Verified for 99% Purity
  • Free Shipping on Orders Over $100+

Description

GW 0742 – Product Information

GW 0742 is a PPARβ/δ agonist, which is being dubbed as a ‘Super Cardarine‘.

Studies have shown GW 0742 has the ability to improve glucose homeostasis and increase insulin sensitivity in diabetic rats. In diabetic rats fed a high fructose diet, a group given GW 0742 showed lower blood sugar compared to the control group.

Due to GW 0742 being a PPAR agonist, it showed the potential in increasing fat loss by boosting metabolism and stimulating the utilization of fat for fuel.

This could potentially increase the oxidative capacity of muscles helping burn more calories.

GW0742
CAS Number 317318-84-6
Molar Mass 471.48 g/mol
Chemical Formula C21H17F4NO3S2
IUPAC Name 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid

How does GW 0742 Work?

Research has shown that GW 0742 has weak activity on multiple nuclear receptors. It has been found to antagonize androgen receptors (ARs) and vitamin D receptors (VDR). GW 0742 has also demonstrated effects on thyroid hormone receptors. [R][R]

GW 0742 Vs Cardarine

GW 0742 and Cardarine are PPAR (peroxisome proliferator-activated receptor) agonists.

Both of them were originally developed by Glaxo Smith Kline. Animal studies have shown that both of them may improve insulin resistance in research subjects. They are also credited for potentially stimulating fatty acid oxidation (reducing levels of fatty acids) in animals.

However, both of them have one major difference. While GW 0742 comprises two hydrogen and four fluorine atoms, Cardarine is made up of one hydrogen and three fluorine atoms. That is to say that GW 0742 is a fluorinated analog of Cardarine. [R]

PureRawz sells GW 0742 and Cardarine for laboratory research use.

GW 0742 Research

While clinical research is lacking on GW 0742, the PPAR agonist has been extensively studied in animal and cell-based studies. The latter have shown that GW 0742 may have the potential to achieve diet-induced weight loss, visceral fat reduction (burn fat), and increased insulin sensitivity in research subjects. [R]

GW 0742 and Metabolism

A study was conducted to investigate whether PPARβ/δ agonist treatment would improve the immune-metabolic changes induced by exercise in diet-induced obese mice. Results demonstrated an increase in fatty acid oxidation gene expression and AMPK activity.

These effects were associated with decreased visceral adipose tissue mass (burns fat) and skeletal muscle inflammation and increases in skeletal muscle oxidative capacities and insulin sensitivity. [R]

GW 0742 and Insulin Resistance

Insulin resistance is an abnormal condition in which your cells don’t respond as they should to insulin. Its development leads to increased insulin production in the body, which, in turn, is associated with high blood pressure, atherosclerosis (hardening of the arteries), and higher triglyceride levels. [R]

GW 0742 has been shown to ameliorate metabolic abnormalities, including insulin resistance in skeletal muscle in mice fed high-fructose corn syrup. However, the influence of GW 0742 on systemic insulin sensitivity has still not been elucidated. [R]

GW 0742 and Inflammation

A study was conducted to investigate the effects of GW 0742 on inflammation. It found that the PPAR agonist reduced many inflammatory and apoptotic (cell death) parameters. Taken together, the results show that GW 0742 reduces lung inflammation induced by bleomycin instillation in mice. [R]

GW 0742 and Diabetes

Data from an animal-based study shows that GW 0742 has the ability to improve glucose homeostasis (glucose uptake) in diabetic rats through the activation of PPAR –δ. Therefore, PPAR-δ is a good target for the development of anti-diabetic drugs in the future. [R]

GW 0742 and Hypertension

A 2011 study set out to investigate whether GW 0742 might exert anti-hypertensive effects in spontaneously hypertensive rats (SHRs). GW 0742 induced a progressive reduction in systolic arterial blood pressure and heart rate in SHRs. Based on the results, the researchers proposed PPARβ as a new therapeutic target in hypertension. [R]

GW 0742 FAQs

Is GW 0742 legal?

GW 0742 is legal to buy and sell as a research chemical. This designation restricts the use of this compound for scientific and research purposes only.

Does GW 0742 suppress natural testosterone?

In any of the studies conducted on GW 0742 to date, there isn’t any mention of fat loss. More studies are thus needed to verify or refute this assertion.

Does GW 0742 suppress glucose metabolism?

Data obtained from animal studies have shown that GW 0742 has the potential ability to improve glucose homeostasis in diabetic rats through the activation of PPAR- δ.

Where to Buy GW-0742 Online

PureRawz is the best place to buy GW 0742 for sale.

In order to be the best research chemicals supplier, we provide reference materials with every product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

Summary

GW 0742 is a PPAR receptor agonist that has demonstrated the potential ability to reduce inflammation, improve hypertension and ameliorate metabolic abnormalities in mice. However, in the absence of human studies, its effects need further investigation.

Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.
All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions.
Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

COA

COA GW 0742 lot 0009 2023 08 17 PR1 1

5 reviews for GW 0742

  1. Marlen Vender

    I feel stronger after my first cycle. I am impressed with my muscle mass gains and lower fat percentage. Perfect for prep.

  2. Vance Rogers

    As an older guy, this product has really aided me in gaining energy and decreasing body fat. Excellent work, Purerawz crew!

  3. Ty Schwartz

    Awesome quality and strength!
    It’s given me some crazy endurance, so I can crush cardio workouts without feeling exhausted. It’s also a total game-changer for shredding fat, so it toned my muscles more than I could expect. Definitely recommend.

  4. Floyd L. Kearney

    Fantastic product.

  5. Paul

    Decreases your bad cholesterol (LDL) and increases your good cholesterol (HDL).

Earn 10 points by reviewing this product.
Add a review

Please click here to access instructions on how to make a payment.

How to Pay