Humanin – Product Information
Humanin is a small peptide that is encoded by the mitochondrial 16S rRNA gene. It was initially discovered in 2001 and has since gained attention for its potential roles in various biological processes, including cellular protection, anti-aging, and neuroprotection.
- Humanin is offered in 10mg lyophilized powder.
|Molar Mass||2657.3 g·mol−1|
What is Humanin Peptide?
Humanin (HN) is a polypeptide and a naturally-occurring micro peptide that has been shown in studies to suppress neuronal cell death caused by various Alzheimer’s disease genes.
Humanin is encoded in mitochondrial DNA and acts as a cytoprotective protein, protecting cells from apoptosis (programmed cell death). To do this function, Humanin binds to certain proteins that signal the destruction of cells, where it shuts down the apoptosis origin pathway.
Certain tests have also shown that Humanin can protect the cells from the lethal process of apoptosis and keeps the cells healthy, even protecting the neurons, muscle cells, cardiac tissue, and the retina of the eye.
Humanin treatment, as confirmed by certain studies, has been shown to improve cardiovascular disease and Alzheimer’s disease. [R]
Despite the seemingly several health advantages of Humanin, the mitochondrial-associated peptide is still unsafe for human consumption.
The alleged effects of the drug should not be viewed as an effective cure for any disease. Buy Humanin for research purposes only.
Potential Applications of Humanin
Humanin is one of the known mitochondrial-derived peptides. Because this genome is so important, this peptide has been studied for its role in a variety of diseases, including cancer, diabetes, and neurodegeneration.
Humanin and Cellular Longevity
Growth hormone (GH) has been shown in studies to have a negative impact on HN peptide levels. For example, research shows that mice who could not produce enough GH had higher levels of HN and lived longer than mice who could produce enough GH. [R]
Furthermore, HN has the ability to control cell death, improve insulin sensitivity, reduce inflammation, inhibit cell death, and degrade atherosclerotic plaques. [R]
Humanin and Alzheimer’s Disease
A 9-month-old mouse model which already had high levels of amyloid proteins was used in the study. These amyloid chemicals are associated with familial Alzheimer’s disease genes. [R]
Some of these mice were given Humanin, and others were given a placebo.
Following the studies, it was discovered that the mice treated with the vehicle still had impaired memory and poor learning skills. The mice treated with Humanin for 3 months had significantly improved learning ability and memory.
Another study suggested that Humanin could be used as a preventative therapy for Alzheimer’s disease. However, more research about Humanin’s impact on Alzheimer’s disease is needed. The compound cannot be used as a valid treatment for AD.
Humanin’s Role in Hypoxia and Brain Ischemia
A study was carried out in which isolated retinal cells were treated with cobalt chloride, which causes hypoxia and cell apoptosis. When hypoxia-induced cells were treated with Humanin, the peptide reversed cobalt chloride’s effects and protected the cells from low oxygen levels. [R]
In addition, selected studies have shown that Humanin is capable of increasing metabolic activity and, thus, cell survival rates in the event of lymphocyte death. This suggests that Humanin could be used to treat poor metabolism and brain ischemia. [R]
Humanin Peptide in Insulin Resistance and Weight Gain
A study was conducted on non-obese diabetic mice to determine whether Humanin can help delay or treat diabetes. Humanin treatment restored glucose tolerance levels in these mice within 6 weeks of treatment. In addition, Humanin treatment delayed the onset of diabetes in mice treated for 20 weeks.
In another study, 12-week-old mice were fed a 60% high-fat diet and given 2mg/kg Humanin via intraperitoneal route for 4 weeks. There was no difference in food intake after the treatment, but body weight gain was reduced by about 20%. In addition to increased insulin levels, there was a high expenditure of energy and a decrease in fasting glucose levels.
This occurrence suggested that the peptide aids in the prevention of fat accumulation (due to increased energy expenditure) and body weight gain. [R]
Humanin and Age-Related Macular Degeneration (AMD)
The retinal pigment epithelium (RPE) is a layer of the retina that covers and nourishes the vision-producing cells. It absorbs and scatters light, filters blood components that reach the inner retina, and establishes the inner eye’s immune-privileged nature. Age-related macular degeneration and diabetic retinopathy both cause RPE damage.
According to research, Humanin is an important component of the RPE and reduces oxidative stress in this tissue. Humanin supplementation improves RPE function and increases the tissue’s resistance to apoptosis in cell culture.
Scientists hope that this will help them develop more effective treatment and prevention strategies for retinal diseases like macular degeneration. [R]
Humanin peptide protects neurons in two distinct ways, according to clinical research. Mitochondria are prevented from activating the death pathway as a result of these two methods. Humanin inhibits the action of Bcl-2 boosting proteins tBid and Bid, preventing them from activating the apoptotic signaling pathway. [R]
According to research conducted in rats, Humanin protects neurons in the context of Alzheimer’s disease by reducing cell death caused by beta-amyloid plaque buildup. Humanin, an antioxidant, has also been shown, in high-intensity NMDA pulse studies to protect against excitotoxic cell death.
Scientists believe that with more robust research, Humanin’s function in treating neurodegenerative diseases such as Alzheimer’s disease and other forms of dementia could be a viable treatment option in the near future.
Humanin, a neuroprotective protein secreted by astrocytes, has been discovered by researchers in Argentina to protect synapses in hippocampus neurons. Humanin supplementation has been shown to be beneficial for older animals in reducing age-related diseases. [R]
Humanin and Heart Disease
Based on research, Humanin peptide helps to protect blood vessels from the aftereffects of bad cholesterol, also known as oxidized LDL cholesterol. It also inhibits the formation of free radicals in response to LDL oxidation, reducing the species in the vasculature by half. Surprisingly, it also reduces apoptosis by 50%. [R]
Because Humanin peptide levels decline with age, it is critical to maintain them at a stable level to protect your health.
According to new heart disease research, the peptide Humanin can be used as both a diagnostic marker and a treatment for cardiovascular disease.
Humanin and Cancer
Carcinogenic mice were induced with two weekly injections of Bortezomib (0.8 to 1 mg/kg) and Humanin peptide (1 micron.). Bortezomib is a newer medication that is being studied for childhood factors.
While Bortezomib caused cell apoptosis, co-treatment with Humanin was completely effective and reversed the apoptosis of healthy cells.
This scientific research demonstrates that mitochondrial-derived peptide Humanin can protect cells from the harmful effects of chemotherapeutic agents and prevent carcinogenesis. [R]
How Does Humanin Peptide Work?
The mitochondrial-derived peptide Humanin performs its various functions by binding with intracellular molecules and cell membrane receptors, inducing cytoprotective and neuroprotective effects.
Humanin peptide binds to the X protein associated with Bcl-2 (also called Bax protein). The Bax protein is essential in the process of cellular death (apoptosis). It inhibits the changes in the Bax protein when it binds to the inactive form of the Bax protein. Thus, humanin peptide suppresses apoptosis. [R]
Humanin, in addition to Bax, binds to other intracellular molecules such as actinin-4 and phosphoprotein 8, both of which are involved in cellular apoptosis.
Humanin induces cytoprotective actions after binding to these proteins. [R]
Humanin peptide binds to two G protein-coupled peptide receptors, FPRL-1 and FPRL-2. Both of these receptors play a role in the pathophysiology of Alzheimer’s disease. [R]
By binding to this receptor, the Humanin peptide prevents amyloid from binding to the FPRL-1 and FPRL-2 receptors, preventing the development of Alzheimer’s disease. This demonstrates the peptide’s neuroprotective properties. [R]
Potential Safety and Side Effects
Humanin is a unique endogenous peptide derived from the mitochondrial genome. Humanin is made up of 21 to 24 amino acids, depending on where it is synthesized.
It primarily exerts its neuroprotective and cytoprotective effects by binding with the body’s intracellular or extracellular receptors. Humanin has been shown to play an important role in the prevention of diseases such as ischemia and Alzheimer’s, as well as a variety of other health benefits such as cellular apoptosis prevention, increased longevity, and reduced insulin resistance.
While research has shown auspicious results with Humanin administration thus far, clinical trials on Humanin are still pending, given that the peptide was discovered only about 15 to 20 years ago.
Clinical trials are currently underway to fully investigate the profile of this peptide and, potentially, establish its use as a therapeutic agent in the treatment of commonly occurring neuro disorders.
For now, less significant side effects of the peptide have been identified. The limitations in humans have yet to be determined because research is still ongoing.
Frequently Asked Questions
Is Humanin safe?
Because the research is limited Humanin cannot be considered safe for human consumption.
Where can you buy Humanin peptide?
Pure Rawz is the best online store to buy Humanin peptides. We offer other peptides that you can use for your clinical trials and research studies.
We provide reference materials with every product we sell to be the best supplier of research chemicals. Our products are all accompanied by an independent, third-party Certificate of Analysis for identification, purity, and concentration.