Huperzine A 1%

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Huperzine A 1% – Product Information

The discovery of Huperzine A 1% and its possible cognitive advantages has piqued the scientific and medical societies’ curiosity. Its origins may be traced back to traditional Chinese medicine, and it has been intensively investigated for its effects on memory and mental function since its isolation. While more study is needed to completely understand the advantages and hazards of Huperzine A, it remains an intriguing molecule with potential uses in cognitive improvement.

Huperzine A 1%
CAS Number 102518-79-6
Molar Mass 242.32 g/mol
Chemical Formula C15H18N2O
IUPAC Name (1R,9S,13E)-1-Amino-13-ethylidene-11-methyl-6-azatricyclo[^2,7]trideca-2(7),3,10,13-tetraene-5,8-dione

What is Huperzine A 1%?

Huperzine A 1% is a natural alkaloid substance obtained from the Chinese club moss plant (Huperzia serrata). It has a long history of usage in traditional Chinese medicine to improve memory and cognition. The chemical has been thoroughly researched for its possible neuroprotective and cognitive-enhancing properties. (R)

Huperzine A 1% acts by blocking acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine. Acetylcholine levels are important for memory, learning, and general cognitive function. Huperzine A 1% raises acetylcholine levels in the brain by blocking AChE, potentially improving cognitive function including memory and attention. (R) 

Huperzine A 1%’s regulatory status as a dietary supplement may differ based on the nation or location. The Food and Drug Administration (FDA) does not officially approve dietary supplements in the United States, including Huperzine A 1%. Dietary supplements, on the other hand, are governed under the Dietary Supplement Health and Education Act (DSHEA) of 1994. (R) (R)

Compound makers are responsible for verifying the safety and labeling accuracy of their goods under DSHEA. If compounds are discovered to be hazardous or mislabeled, the FDA has the authority to take action. As a result, Huperzine A 1% can be lawfully sold in the United States, but the manufacturer must comply with FDA restrictions. [R]

PureRawz sells Huperzine A1% for Research purposes only.

Huperzine Plant Extract vs Huperzine Synthetic

The difference between Huperzine A 1% synthetic and Huperzine A plant extract lies in their origin and manufacturing process.

Huperzine A 1% synthetic is chemically synthesized in a laboratory setting, where the compound is artificially created through chemical reactions. The synthetic form aims to replicate the molecular structure and properties of the natural Huperzine A compound found in plants. It is produced under controlled conditions to ensure purity and consistency.

On the other hand, Huperzine A plant extract is derived from natural sources, typically from plants such as Huperzia serrata (Chinese club moss). The plant material is processed to isolate and extract the Huperzine A compound. Plant extracts may contain additional phytochemicals and compounds that naturally occur alongside Huperzine A in the plant.

In terms of their efficacy, both synthetic Huperzine A 1% and plant extract are believed to provide similar research applications.

Potential Application of Huperzine A 1%

Cognitive Enhancement

Huperzine A 1% (Huperzia serrata) has been researched for its potential ability to improve cognitive performance. According to research, it may increase levels of memory, learning, and general cognitive ability. It accomplishes this by blocking the enzyme acetylcholinesterase, which raises acetylcholine levels, an essential neurotransmitter involved in memory and cognition. (R)

In 2017, the Journal of Neural Transmission released research that looked at the effects of Huperzine A on memory and cognitive performance in older subjects. Huperzine A increases levels of memory and cognitive function in the randomized, double-blind, placebo-controlled study participants. (R)

Another research published in Psychopharmacology in 2016 looked at Huperzine A’s impact on working memory in young subjects. In comparison to the placebo group, Huperzine A treatment dramatically enhanced working memory performance. (R)

Potential Treatment for Alzheimer’s and Dementia

Huperzine A 1% has been explored as a possible therapy for Alzheimer’s disease and other kinds of dementia due to its ability to inhibit acetylcholinesterase. Research suggests that it may help decrease the rate of cognitive loss and improve symptoms in subjects with these illnesses. (R) (R)

The effects of Huperzine A were examined in individuals with mild to severe Alzheimer’s disease in a clinical trial that was published in the Journal of Alzheimer’s Disease in 2015. In comparison to the placebo group, the study showed that Huperzine A medication enhanced cognitive performance and daily living activities. (R)

Animal studies have also indicated the efficacy of huperzine A in Alzheimer’s disease, with one such study appearing in Neurobiology of Aging in 2014. According to the study, Huperzine A therapy enhanced cognitive performance and decreased the buildup of amyloid-beta plaque in transgenic mice models of Alzheimer’s disease. (R)


Huperzine A 1% has shown neuroprotective qualities in several trials. It has been demonstrated that it can potentially assist in defending neurons against oxidative stress, inflammation, and other harmful activities. This raises the possibility of a part in the management or prevention of neurodegenerative illnesses. (R)

Animal studies, such as one published in Brain Research in 2018, have explored the neuroprotective effects of Huperzine A in models of cerebral ischemia. The findings demonstrated that Huperzine A administration reduced brain damage, improved neurological function, and increased antioxidant defenses in animals subjected to ischemic stroke. (R)

Stroke Recovery

Studies have suggested that Huperzine A 1% may potentially help subjects recover from strokes. It can lessen brain damage after an ischemic stroke and increase levels of motor function recovery, according to studies in animal models. To investigate its potential in human stroke patients, more study is required. (R)

An animal study published in Life Sciences in 2017 investigated the effects of Huperzine A on functional recovery after ischemic stroke. The results showed that Huperzine A treated motor function recovery and reduced brain damage in rats subjected to cerebral ischemia. (R)

Mental Health Disorders

Early research indicates that Huperzine A 1% may be effective in treating mental health conditions including anxiety and depression. Its potential as an additional therapy for various disorders may be influenced by its capacity to alter neurotransmitters and enhance cognitive function. To determine its effectiveness and safety, another study is necessary. For example, a study published in Behavioural Brain Research in 2014 found that Huperzine A exhibited antidepressant-like effects in a mouse model of depression. (R)

How Does Huperzine A 1% Work?

Huperzine A 1% (Huperzia serrata) works by suppressing the enzyme acetylcholinesterase (AChE). Acetylcholinesterase is in charge of degrading the neurotransmitter acetylcholine in the brain. Acetylcholine is necessary for memory, learning, and general mental function. (R)

Huperzine A 1% as the active ingredient penetrates the central nervous system after crossing the blood-brain barrier. It attaches to and inhibits acetylcholinesterase once it potentially enters the brain. Huperzine A 1% inhibits this enzyme, potentially allowing acetylcholine to build and remain active in the brain over prolonged periods.

Acetylcholine increases cholinergic neurotransmission, which is involved in a variety of cognitive activities. Acetylcholine functions in the brain as a signaling chemical, enhancing neuron connection and promoting memory formation, learning, and attention. By inhibiting AChE, Huperzine A can potentially enhance cholinergic neurotransmission and improve muscle function in myasthenia gravis patients. (R)

It also helps sustain greater acetylcholine levels by inhibiting acetylcholinesterase, resulting in better cholinergic neurotransmission and perhaps improved cognitive performance. This method of action is similar to that of other acetylcholinesterase inhibitors used in Alzheimer’s disease therapy, however, Huperzine A 1% is generated from nature. (R)

Take note, while acetylcholinesterase inhibition is the major mechanism of action for Huperzine A 1%, it may also have effects on other neurotransmitter systems and brain functions. More study is being conducted to better fully understand the full range of its actions and potential benefits. (R)

Frequently Asked Questions (FAQs)

What is Huperzine A 1%?

Huperzine A 1% is a natural compound derived from the Chinese club moss plant (Huperzia serrata). It is known for its potential cognitive benefits, including memory enhancement and improved focus.

What are the potential applications of Huperzine A 1%?

Huperzine A 1% has been researched for potential applications, including cognitive enhancement, Alzheimer’s disease and dementia, neuroprotection, stroke recovery, and mental health disorders. However, it is essential to note that further research is needed to establish its efficacy and safety in these specific contexts. 

What forms of Huperzine are available in the market?

Huperzine is commonly available in two forms: powder or capsules Huperzine. Both forms offer the same Huperzine compound and potential research applications.

How should Huperzine A be stored?

Huperzine A 1% should be stored in a dry, cool place, away from direct sunlight and moisture.

Can Huperzine A be stacked with Alpha GPC?

Yes, Huperzine A can be stacked with Alpha GPC. When combined, these two supplements are often used to potentially enhance mental function. Huperzine A works by inhibiting the enzyme that breaks down acetylcholine, while Alpha GPC provides the building blocks for acetylcholine synthesis. The goal of combining them is to increase acetylcholine levels in the brain, potentially improving memory, focus, and overall cognitive performance in research subjects.

Is Huperzine A 1% legal?

The regulatory status of Huperzine A 1% as a dietary supplement may vary depending on the country or region. In the United States, it can be legally sold as a dietary supplement under the regulations of the Dietary Supplement Health and Education Act (DSHEA) of 1994. However, regulations may differ in other countries, so it is important to check local government regulations regarding its sale and use.

Can Huperzine A 1% be used in laboratory studies?

Yes, Huperzine A 1% is commonly used in laboratory studies to investigate its effects on memory, cognition, and neuroprotection. Researchers often employ it to study its mechanisms of action and potential applications in various research models.


Huperzine A (Huperzia serrata) is a natural chemical obtained from the Chinese club moss plant. It has been investigated for potential cognitive-enhancing benefits, notably in memory and attention. Huperzine A 1% boosts the levels of acetylcholine, a neurotransmitter related to mental function, by blocking the enzyme acetylcholinesterase (AChE). This technique might result in better memory, learning, and attention. Huperzine A 1% has also demonstrated neuroprotective effects and is being investigated as a possible therapy for illnesses such as Alzheimer’s disease and stroke recovery. While it is typically safe for short-term usage, it may induce negative effects such as gastrointestinal problems. More study is being conducted to better understand the entire scope of its effects and possible uses. (R)

Where to Buy Huperzine A 1%?

PureRawz is the best place to buy the highest-quality Huperzine A 1% for sale online!

To ensure quality as a research chemical supplier, we include reference materials with each product and provide an independent Certificate of Analysis from a third party for identification, purity, and concentration verification.

We offer free international shipping for orders exceeding $100 and accept multiple payment options such as PayPal and Bitcoin. Our product range consists of liquid, powder, and capsule formulations of TUDA, all of which are of equally exceptional quality.


This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

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4 reviews for Huperzine A 1%

  1. Randy H Gonzalez

    I have used Huperzine A for a while now. It looks like it helps with my memory. I can remember people’s names better, which is very important in my job.

  2. Bryan Kelly

    I always hear good things about his product on our website. You have not let me down so far. I will be a regular customer moving forward.

  3. HMarks

    This really helps my memory.

  4. Cleveland Mann

    Clean modern looking website. The ordering was straight forward. Price is fair. The products are exactly what I wanted. Great Job!

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