Ibutamoren (MK-677)

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Ibutamoren (MK-677) – Product Information

MK-677 or Ibutamoren is an anabolic research compound that is popular amongst researchers, especially in animal studies, for its promising potential to effectively increase lean body mass with an aim to grow muscle. Due to the potential ability to increase growth hormone levels, the research aims have shifted towards the potential efficacy of MK-677 supplementation as a means of elevating muscle mass, and muscle strength, and reducing overall body fat.

Studies indicate that MK-677 compounds may spur the growth of new muscle cells by signaling the pituitary gland to create more growth hormones and by stimulating IGF 1 release in the liver. According to studies, these hormones together may increase protein synthesis and strength while simultaneously boosting recovery rate and enhancing nitrogen retention.

In a double-blind randomized controlled trial, 24 obese mice received MK-677 therapy for two months. Results showed their basal metabolic rates and muscle mass increased. Another study on mice found that MK-677’s effects reversed muscle wasting and muscle loss. Meanwhile, another study carried out on mice suffering hip fractures found evidence of improved muscle strength when administering an MK-677 research cycle.

MK 677 Ibutamoren
CAS Number 159634-47-6
Molar Mass 528.67 g/mol
Chemical Formula C14H12F6N2O
IUPAC Name 2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propenamide

How Does MK 677 Work?

Animal studies have shown that MK 677 mimics the action of ghrelin, the growth hormone (GH) secretagogue that stimulates the release of GH. MK 677 works by attaching to one of the brain’s ghrelin receptors (GHSR) and activating them, increasing GH levels.

Multiple studies have confirmed MK 677’s potential ability to raise GH levels. One study on dogs showed that Ibutamoren elevates GH after oral doses as low as 0.125 mg/kg. Another animal study found that prolonged administration of MK-677 increased peak GH concentrations. [R] [R]

Three double-blind, placebo-controlled clinical studies reached the same conclusion. Subjects were given bodyweight-dependent doses of MK 677 for 2 – 9 weeks. The final results showed a sustained increase in GH levels compared to samples collected at the study’s onset. [R]

MK-677 and SARMs

Despite being a growth hormone secretagogue, MK 677 is often grouped with selective androgen receptor modulators or SARMs. This is mainly because it has produced a somewhat similar set of effects in animal, pre-clinical, and clinical studies.

However, despite producing similar effects, MK 677 is not a SARM. Selective androgen receptor modulators work by binding to androgen receptors, mainly in the muscle and bone tissue. Ibutamoren, as stated above, has the potential to mimic the action of ghrelin in the brain.

If effects are to be considered, Ibutamoren finds its place in the growth hormone-releasing family of peptides. Like Hexarelin, GHRP-2, and GHRP-6, MK 677 attaches to the ghrelin/growth hormone secretagogue receptor to stimulate GH release.

It might be beneficial that Ibutamoren is not a SARM. SARMs may impact natural androgen production and lower testosterone levels. Researchers thus have to take many precautions when administering SARMs to research subjects. MK 677 doesn’t need similar precautions.


MK-677 Research Stacks Well With:


MK-677 Ibutamoren Research

Multiple animal studies have been conducted using MK-677. This GH-secretagogue has also attracted various clinical trials. In this section, we’re going to take a comprehensive look at what these studies have found about Ibutamoren.


MK-677 and Growth Hormone

A study was conducted to determine the effect of MK-677 on growth hormone release in obese subjects. The study involved oral treatment of MK-677 and recruited twenty-four healthy obese subjects. The impact of oral administration of MK 677 on GH secretion was observed.

The final results showed that there was a significant increase in GH levels. Another encouraging sign was that the increase persisted at 2 and 8 weeks of treatment. It was also observed that the initial dose of MK-677 produced a greater increase in GH levels than any of the upcoming doses. [R]


MK-677 and IGF-1

Insulin-like growth factor 1 is a hormone that plays many crucial functions in the human body. These include fetal development, childhood growth, and anabolic effects in adults. Aside from that, IGF-1 has also been proven to help with muscle regeneration and offer neural protective effects. [R]

A double-blind study has shown that MK-677 could potentially increase IGF-1 levels in patients with mild to moderate Alzheimer’s disease. A 60.1% increase was observed 6 weeks after the beginning of MK-677 treatment. The rate of increase reached 72.9% at 12 months. [R]


MK-677 and Body Composition

In a 24-month-long placebo-controlled trial, Ibutamoren administration led to increased GH and IGF-1 levels with no severe side effects in research subjects. Researchers demonstrated that this resulted in a potential increase in body weight, a decrease in LDL (“bad”) cholesterol levels, and an increase in bone density. [R]

Similar results were obtained following a two-month treatment of obese subjects with MK-677. Fat-free mass saw a significant increase in the Ibutamoren treatment group, compared to the placebo group. However, no effect on body fat was observed. [R]


MK-677 and Bone Density

There is a direct relationship between GH levels in the body and bone mineral density. Various studies show that an increase in GH leads to stronger bones. That explains why older adults, who have lower GH levels than their younger counterparts, tend to have weaker bones. [R]

Research involving elderly adults found that MK-677 has the potential to stimulate bone turnover and increase bone deposition and formation. This could positively impact bone density, as highlighted by another study in which MK-677 treatment improved gait speed and reduced the number of falls in elderly patients with hip fractures. However, more research is needed. [R] [R]


MK-677 and Sleep Quality

Sleep is one of the most essential body functions. Research has shown that a good night’s sleep can boost learning, decision-making, memory, and creativity. What’s more, short sleep duration and poor sleep quality are linked to mass muscle reduction. [R]

To determine the impact of MK-677 on sleep quality, one study group was administered this GH secretagogue while the other was given a placebo. Results showed that the MK-677 group had a 20% increase in REM sleep and a 50% increase in the duration of stage IV compared to the placebo group. [R]


MK-677 FAQs

Where to Buy MK677 for Research Purposes?

We offer free shipping on all orders above $100. The MK-677 for sale comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration. Our great customer service and fast shipping help us stand out from the competition.


What Is The Half-Life of MK 677?

Animal research indicates that MK-677 has an elimination half-life of 4-6 hours.

What Are The Potential Side Effects of MK-677?

A two-year clinical study indicates that the most frequent side effects of MK-677 on research subjects tend to be mild. These include increased appetite, transient muscle pain, and lower-extremity edema. Researchers conducting the study noted that most side effects subsided in a few months.


MK-677 Summary

MK677 or Ibutamoren is a growth hormone secretagogue. Research conducted on animals as well as multiple clinical studies has shown that it has the potential to increase levels of GH and IGF-1.

Aside from that, several clinical trials have shown that this research chemical is generally safe. However, it is yet to be approved for human consumption and can only be acquired for laboratory research use.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.


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97 reviews for Ibutamoren (MK-677)

  1. Robert Minarik

    The product arrived safely. Thanks

  2. Olly Mitchels

    Outstanding quality.

  3. Bret S.

    Works very quickly. Great stuff. A little nausea at first. Does cause a rise in blood sugar level.

  4. Jackson Lenas

    Super quality!

  5. Jake Hill

    Amazing product with speedy results.

  6. Lyle Turner

    Fantastic product, fast shipping and very helpful customer service.

  7. James Brown

    Really helps to assist lean muscle gains.

  8. Donald Hagan

    Definite strength improvement. Will recommend your product.

  9. Robin Adair

    Been lifting heavier than ever.

  10. Julie M

    Fast shipping.
    Seeing results even in skin, nail, hair health

  11. Steven Brewer

    Can highly recommend this MK!

  12. Daniel Ulster

    The gains are so worth it!

  13. Tommy Vargas

    Great quality. Slept way better and gains came fast. Definitely recommending this to my friends

  14. Arthur Rendell

    Muscle gains fantastic.

  15. bigcajun-2784

    This is my go to to add to any stack. Just adding with regular trt is a guaranteed 15 to 20 pound increase in a few week while keeping roughly half of it after its finished. Increased appetite, better sleep and quicker recovery

  16. Dave

    Worth the buy! This is a must have product!

  17. Nick Kling (verified owner)

    A little pip for a few days with the injectable. Besides that it works well and you feel it instantly. Shipping as with all products us quick and secure .

  18. vasquezjacob203

    This product helped me gain several kilos of lean muscle in just 1 cycle. Amazing!

  19. Mohammed S

    Great product for fast gains and overall health ,excellent customer service

  20. Anan Izar

    Customer service was amazing and very friendly. And about the product, I’m Still using it and it’s working great on me.

  21. Anonymous

    Hey PureRawz! Thank you, I just want to notify you guys that I received my order today. You guys really have an amazing customer service. Good job.

  22. Cody Corbett

    Had good results gained weight but be prepared for being super hungry

  23. Brian Picariello

    Great recovery and joints felt way better plus increased appetite

  24. Neil Shipton

    Fast shipping. Good packaging. Great recovery after training hard.

  25. Ralph Wood

    This stuff works, simply said. I feel fully recovered after crucial workouts. If you are looking to feel better and more energized , then this is what you need!

  26. Noel Zimmerman

    Real results!

  27. Dough Sterling

    Never had anything like this, to be honest. Minimal after effects. Just perfect!

  28. Anonymous

    Strength gains for me.

  29. Vaughan D.

    Very happy with what I received. One of the best Mk’s on the market.

  30. William Jenkins

    I am impressed – older bodies take longer to react and this has given me the needed boost.

  31. rubenb

    Best product on the market, my lab rats love it

  32. D. Bechtelar

    Took me a few weeks but now I’m starting to really see a difference in my lifts. I feel more ‘alert’ while lifting if that makes sense. I feel more focus and my lifts feel solid and tight.

  33. nickm989 (verified owner)

    Best Sarms available 💯

  34. Christopher (verified owner)

    The injectable MK is unique and amazing, just be patient they are slow in shipping.

  35. Christopher (verified owner)

    Injectable MK is unique and amazing !

  36. Clayton K

    Arrived in a timely manner and works great.

  37. Grant Mansill

    Great quality, saw strength gains within the first two weeks.

  38. Ryan

    Customer service is great. Product is high quality and works very well.

  39. Frank Bent

    Very good product! My first time and will come back again

  40. Endri Dedja

    It helps me gain muscle. I bought here and New Sarms they are the best

  41. Mohan Ali (verified owner)

    Let’s start by shipping….. these guys ON POINT! You’ll receive your shipment within 12 days as expected. The packaging is above and beyond any product I’ve purchased from any other supplier. Now the main reason of this review, the MK677!!! This is by far the best product I’ve ever purchased. If you know how to use it and when to use it, I can’t tell you enough about the results. I use MK677 with RAD 140 which’s another phenomenal product from PureRawZ and the gain I receive is what I expect.

    This is not a magical product y’all, however, the results is magical if you follow the proper process and let the muscles gain through hard work and determination. Eat healthy, work hard and enjoy the gain!

  42. LaQuintice (verified owner)

  43. Ron Snitkovsky (verified owner)

  44. Michael (verified owner)

    Has helped me stay low in body fat but I see that I look bigger and feel stronger

  45. Carlos Gabriel Carranza R. (verified owner)


  46. Verified Buyer (verified owner)

  47. joshua (verified owner)

    Glad to say this is the real stuff.

  48. Verified Buyer (verified owner)

  49. James (verified owner)

    Everything was good with this order.

  50. Matthew (verified owner)

  51. Andrew (verified owner)

    Great product. The health benefits were noticeable on day 2. I’ve ordered another 2 month supply. Delivery was 5 days and discrete.

  52. Verified Buyer (verified owner)

  53. Verified Buyer (verified owner)

    works. not super strong but will definitely notice it.

  54. James Brock (verified owner)

    Everything was good, alittle late on delivery, USPS I assume, thank you

  55. Verified Buyer (verified owner)

    Good product

  56. Michael G. (verified owner)

    Used to take this few years ago back on it the hunger is like next day kicks in sleep is harder and growth kicks in about 3 months for me love it

  57. Jeremy (verified owner)

    Subject saw improvements in strength and recovery

  58. sergio (verified owner)

  59. Andrew (verified owner)

  60. Anonymous (verified owner)

  61. brent o. (verified owner)

  62. deniyel v. (verified owner)

    effects noticeable

  63. Anonymous (verified owner)

  64. Joseph (verified owner)

  65. Frank D. (verified owner)

  66. Devin Cullum (verified owner)

  67. Richard (verified owner)

    Helps me put on weight.

  68. Nicole B. (verified owner)

  69. chad lucas (verified owner)

  70. Greg Moore (verified owner)

    Good stuff

  71. Ron Snitkovsky (verified owner)

  72. Tanner (verified owner)

  73. Jim Ryan (verified owner)

    This product is outstanding and delivers as advertised.

  74. Branden B. (verified owner)

  75. Peter (verified owner)

  76. Anonymous (verified owner)

  77. lucas l. (verified owner)

  78. David

    Got it for my dad he loved it

  79. admin (store manager)

    Perfect Product

  80. Peter (verified owner)

    Product works as described. Very impressive.

  81. Diego Majano (verified owner)

  82. Josh Powell (verified owner)

    It’s important to note glycogen uptake with this product is high.

  83. Branden Barnhart (verified owner)

  84. Glenn M. (verified owner)

    Raw amazing products

  85. Devin G. (verified owner)

  86. Kevin S. (verified owner)

  87. Will (verified owner)

    Has performed extremely well in research.

  88. Thomas (verified owner)

  89. Zachary Barajas (verified owner)

  90. Drew (verified owner)

  91. chad (verified owner)

    Great priduct

  92. Robert alexander (verified owner)

  93. Floyd (verified owner)


  94. Kelly (verified owner)

    Good product great price, both my wife and I take this daily

  95. Shaun Weber (verified owner)

    First time taking any sarms…after 4 weeks a low dose around 8mg a day for the first 4w I definitely felt my muscles fuller

  96. liyivix666

    It really works great for muscle growth

  97. yicej77021

    Helps with muscle growth and sleep. Feeling more energized too.

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