Ipamorelin

(29 customer reviews)

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Description

Ipamorelin – Product Information

Ipamorelin is a pentapeptide, which displays high GH-releasing potency and efficacy in vitro and in vivo. Ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of Ipamorelin makes this compound a very interesting candidate for future clinical development.

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Ipamorelin
CAS number 170851-70-4
Molar Mass 711.868 g·mol−1
Chemical Formula C38H49N9O5
IUPAC Name (2S)-6-Amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(4H-imidazol-4-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

What is Ipamorelin?

Ipamorelin is a research peptide that stimulates the release of growth hormone (GH). It is composed of five amino acids and is thus known as a pentapeptide. Ipamorelin is often lumped together with CJC 1295, though they are two different compounds.

Ipamorelin was originally developed by Novo Nordisk Inc. It was investigated in phase 2 trials as a treatment for postoperative ileus, a condition in which the bowel stops functioning after surgical procedures. However, due to a lack of efficacy, it was discontinued. [R]

Pharmacological profiling using growth hormone-releasing peptide (GHRP) and growth-hormone-releasing hormone (GHRH) antagonists has clearly demonstrated that Ipamorelin stimulates GH release via a GH-like receptor. Its selectivity for GH is similar to that displayed by GHRH.

How does Ipamorelin Work?

Ipamorelin mimics the actions of ghrelin, a gut hormone that affects food intake, fat deposition, and GH release. It binds to the ghrelin receptor (or the GH secretagogue receptor, GHSR) in the brain to selectively stimulate the release of GH from the pituitary gland. [R] [R]

Research has shown that GH secretion goes down with age. The decrease in lean body mass and increase in adipose tissue that occurs with aging has been partly attributed to the age-associated decline in GH secretion and insulin-like growth factor-1 (IGF-1). [R]

Ipamorelin Research

Multiple animal studies have been conducted on Ipamorelin. Phase 2 clinical trials were conducted to study the ghrelin mimetic Ipamorelin for the management of postoperative ileus in bowel resection patients. Let’s look at the research carried out on Ipamorelin to date.

Ipamorelin and Weight Gain

A 9-week animal study was conducted to assess ipamorelin’s effects on adiposity and weight gain. The study involved female GH-deficient and GH-intact mice. After 9 weeks, body weight in the GH-deficient mice increased by 15.3% in those treated with Ipamorelin. [R]

It is worth noting, however, that there were no changes in the relative weight of the dissected organs with Ipamorelin, while GH led to increased liver weight. This suggests that patients treated with Ipamorelin may not experience the same organomegaly as seen in GH-treated patients.

Ipamorelin and Bone Health

Ipamorelin and GH-releasing peptide-6 increased bone mineral content in adult female rats. As measured in vivo, both Ipamorelin and GHRP-6 increased total, tibial, and vertebral bone mineral content compared with the vehicle. All substances also increased the tibial area bone mineral density. [R]

In another study, Ipamorelin dose-dependently increased the longitudinal bone growth rate (LGR) in adult female rats. There was also a pronounced and dose-dependent effect on body weight gain. [R]

Ipamorelin and Glucocorticoids

Glucocorticoids (GCs) are naturally occurring steroids. They perform many functions in the body, including interrupting inflammation and treating conditions caused by inflammation. However, their side effects include weight gain, water retention, and muscle weakness, among others. [R]

In vivo in an adult rate model, the ability of Ipamorelin to counteract the catabolic effects of GC on skeletal muscles and bones was investigated. A group of 8-month-old female rats was injected under the skin for 3 months with GC (methylprednisolone), GHS (Ipamorelin), or both.

In conclusion, the decrease in muscle strength and bone formation in GC-injected rats was counteracted by the simultaneous administration of the selective growth hormone secretagogue. The study supports the therapeutic use of GHSs in patients receiving glucocorticoids. [R]

Ipamorelin and Diabetes

Research suggests that Ipamorelin evokes significant increases in insulin secretion from the pancreas of normal and diabetic rats. Ipamorelin stimulates insulin release through the calcium channel and the adrenergic receptor pathways. [R]

The study was conducted to examine the effects of Ipamorelin on insulin secretion from pancreatic tissue fragments of normal and diabetic rats.

Ipamorelin and Muscle Growth

A study was conducted to examine the effects of Ipamorelin to counteract the catabolic effects of glucocorticoids on skeletal muscle and bones. It was shown that Ipamorelin counteracted the decrease in muscle strength and bone formation found in GC-injected rats. [R]

Longer-term clinical trials on randomized populations are needed to investigate the potential anabolic effects of this growth hormone secretagogue.

FAQs

Is Ipamorelin a research chemical?

Yes. This designation restricts the use of research chemicals strictly for laboratory and research use.

What Are Peptides?

Peptides are smaller versions of proteins. They are made up of short chains of amino acids, usually somewhere between 2 and 40.

Is it illegal to buy peptides?

It is illegal to buy and use peptides for purposes other than scientific research.

PureRawz sells peptides for in vitro testing and laboratory experimentation only.

Where to Buy Ipamorelin Online

PureRawz is the best place to buy Ipamorelin online.

In order to be the best research peptides supplier, we provide reference materials with every product we sell. Each of our research peptides comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

Ipamorelin Summary

In animal studies, Ipamorelin improved bone mineral content, counteracted the muscle- and bone-related side effects of glucocorticoids, and improved weight gain. However, in the absence of clinical trials, it is still categorized as a research chemical.

Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.
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COA

COA Ipamorelin lot PRWZ 050 2023 08 23 PR1 1

29 reviews for Ipamorelin

  1. Scott C. (verified owner)

    Good results

  2. Anonymous (verified owner)

    Great quality product

  3. Ed (verified owner)

    Good

  4. James Stingley (verified owner)

  5. Jenny Mullins (verified owner)

    Great product!!!

  6. Leon S. (verified owner)

    This is an incredible product and will continue to purchase.

  7. John S. (verified owner)

    Outstanding

  8. Toni (verified owner)

    Research yielded results beyond expectation! Will never go back to other research chemical companies.

  9. Anonymous (verified owner)

    Worth money

  10. Bill (verified owner)

    Love adding this to my regimen

  11. Anonymous (verified owner)

    So far so good!! Feel great!!

  12. Michael M. (verified owner)

    Awesome

  13. Michael M. (verified owner)

    Good product high price

  14. Raymond D. (verified owner)

    Legit and a great price

  15. BRIAN W. (verified owner)

    Still needing time to rate this product

  16. Jonathan

    This product is worth the money, results are just amazing and the quality is spectacular .

  17. Monique Muller

    I have been using this product for 2 weeks now and I can notice the difference in the way I sleep and with my mood. It also helps me to lose weight. Great product.

  18. Gerrit John

    My research yielded results beyond expectation for this Ipamorelin! I will never go back to other research chemical companies.

  19. Byron K Allen

    So far, I feel great! My energy gets a boost for my workouts, and I have been able to control my cravings while achieving my goals. I have used this for just over two weeks and am so impressed. I will continue to use it.

  20. Sylvester Zamalia

    This was worth saving up for. I have found my new favorite item.

  21. Sam H

    Super fast delivery and remarkable customer service!

  22. P King

    I recommend this product.

  23. Anonymous

    Been gaining an insane amount of muscle mass.

  24. Leo Mueller

    Really awesome product! It’s really good quality and I see great results. Highly recommended!

  25. Frankie L

    Very good results so far, very good quality.

  26. Anonymous

    I can recommend this one!

  27. Jimi (verified owner)

    Great product

  28. John Crawler

    This is a fantastic product that I will keep buying.

  29. Alexandros Osborne

    Great for my overall well-being, will definitely get this with each order from here on out!

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