KPV (Lysine-Proline-Valine)

Description

Overview of KPV (L-Lysyl-L-prolyl-L-valine)

KPV is a short synthetic tripeptide composed of lysine, proline, and valine residues. In research settings, it is commonly examined for its interaction with signaling pathways. It has been investigated for potential interactions with inflammatory signaling pathways in preclinical models.  Rather than being described through outcome-based claims, KPV is more accurately characterized as a laboratory peptide. This is particularly relevant for studying molecular signaling behavior and pathway activity.

Chemical and Molecular Properties 

KPV (L-Lysyl-D-prolyl-L-valine)
PubChem CID	14552272
Molecular Formula	C16H31N5O4
Molecular Weight	357.45 g/mol
Synonyms	L-Lysyl-L-prolyl-L-valine L-Valine L-lysyl-D-prolyl-
IUPAC	(2S)-2-amino-N-[(2S)-1-[[(2R)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]pentanamide
CAS	125905-17-1
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Research Use Only (RUO)
Storage Temperature	Typically −20 °C or −80 °C
Solubility	Generally soluble in water, aqueous buffers, and DMSO, though solubility depends on concentration and formulation conditions.
Safety	Handle using standard laboratory precautions: wear gloves, a lab coat, and eye protection; avoid inhalation of dust or aerosols; use local exhaust ventilation or a fume hood when handling powders or during procedures that may generate aerosols.

Proposed Working Mechanism of KPV (L-Lysyl-L-prolyl-L-valine)

KPV (L-Lysyl-L-prolyl-L-valine) is studied mainly for its role in cellular signaling rather than direct therapeutic applications. Its research focuses on peptide-mediated communication pathways. This research also includes the regulation of inflammatory messengers. Therefore, KPV is positioned within broader cellular signaling processes.

Specifically, it has been investigated for its influence on cytokine-associated signaling. It also involves interaction with NF-κB–related pathways associated with transcriptional activity. Consequently, studies examine its effects on epithelial barrier signaling. Studies have also examined its effects on epithelial tight-junction signaling in cellular models.

KPV may participate in receptor-mediated signaling within immune cell networks. Research also explores its stability, transport behavior, and enzymatic interactions under controlled conditions. This contributes to a clearer understanding of its biological activity.

Why Choose Purerawz for KPV (L-Lysyl-L-prolyl-L-valine)?

Buy KPV (L-Lysyl-L-prolyl-L-valine) for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

KPV (L-Lysyl-L-prolyl-L-valine) is an investigational compound. It is not established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

• National Center for Biotechnology Information (2026). PubChem Compound Summary for CID 14552272, L-Valine, L-lysyl-D-prolyl-. Retrieved April 28, 2026 from https://pubchem.ncbi.nlm.nih.gov/compound/L-Valine_-L-lysyl-D-prolyl.
  
• Sung, J., Ju, S. Y., Park, S., Jung, W. K., Je, J. Y., & Lee, S. J. (2025). Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway. Tissue & cell, 95, 102837. https://doi.org/10.1016/j.tice.2025.102837
• Pawar, K., Kolli, C. S., Rangari, V. K., & Babu, R. J. (2017). Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin. Journal of pharmaceutical sciences, 106(7), 1814–1820. https://doi.org/10.1016/j.xphs.2017.03.017