L-Tetrahydropalmatine (L-THP)

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L-Tetrahydropalmatine (L-THP) – Product Information

  • L-Tetrahydropalmatine is offered as 10g powder.

Levo Tetrahydropalmatine (otherwise called L-THP or tetrahydropalmatine L-THP powder) is a tetrahydroprotoberberine isoquinoline alkaloid with analgesic and anti-inflammatory properties, as well as features that may promote cardiovascular health, improve mood, and reduce stress and anxiety.

This naturally-occurring compound is believed to promote deep and restful sleep. According to certain studies, L-THP compounds, which have the potential to be one of the most effective sleep aids, could offer a relaxing and smooth transition from consciousness to deep and restful sleep. [R]

Although tetrahydropalmatine L-THP powder could possibly foster the benefits mentioned above by following the appropriate dosage advised by research studies, this organic chemical is still inadvisable for human consumption. PureRawz strongly recommends purchasing L-THP for research purposes only.

L-Tetrahydropalmatine (L-THP)
CAS Number 483-14-7
Molar Mass 355.434 g/mol
Chemical Formula C21H25NO4
IUPAC Name (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline

What is L-Tetrahydropalmatine?

L­-THP is the active compound found in the Corydalis Yanhusuo herb. L-Tetrahydropalmatine is being researched for its ability to reduce the onset and development of anxiety and depression-related symptoms induced by single prolonged stress.

L-THP is an isoquinoline alkaloid found in several different plant species, primarily in Corydalis (Yan Hu Suo) genus and other plants, such as Stephania rotunda.

The pharmacological profile of L-THP, which includes dopamine antagonists (D1 and D2) and actions at dopamine D3, alpha-adrenergic, and serotonin receptors, suggests that it may be helpful in controlling addiction.

L-Tetrahydropalmatine (L-THP) is a synthetically produced potent enantiomer thought to be useful as an anxiolytic, sedative, analgesic, and relaxant compound. Preliminary human studies generated promising results. In other research studies, L-THP may also address depression-related symptoms induced by addiction. [R]

What are the Potential Applications of L-Tetrahydropalmatine?

L-Tetrahydropalmatine may contains analgesic properties

Aside from being a potential adrenergic agent, tetrahydropalmatine may also become a potent analgesic via multiple mechanisms. These would include decreasing the abundance of protonated current mediated by acid-sensing ion channels (ASICs) in rat DRG neurons, inhibiting the functional activity of isolated primary sensory neuron ASICs, and relieving pain caused by acidosis. [R]

Supplements of L-THP are thought to possess analgesic effects via D1R agonist and D2R antagonism in mice given an intraperitoneal injection at doses of 5 and 10 mg/kg, resulting in increased mechanical threshold, thermal latency, and nonrapid eye movement sleep. [R]

The berberine alkaloid can also inhibit formalin-induced second-stage pain behavior in the spinal cord via the sig-1R mechanism. It can produce anti-hyperalgesia effects in a dose-dependent manner by intensifying dopaminergic transmission mediated by D1R. [R]

Although L-THP could offer such medical benefits, there is much more to know about its mechanisms of action. Buy l tetrahydropalmatine for your research studies only.

L-Tetrahydropalmatine may have powerful anti-addiction properties

THP may block methamphetamine (METH) effects in all stages of the conditional place preference (CPP) task. [R]

THP, according to pharmacological magnetic resonance imaging, can selectively activate critical regions of the brain’s dopaminergic, serotonergic, and norepinephrine systems. [R]

THP can also inhibit morphine-induced CPP acquisition and expression in a dose-dependent manner. [R]

The anti-addiction benefits of L-THP still require large-scale laboratory studies. The outcomes mentioned above cannot be viewed as conclusive.

L-Tetrahydropalmatine could promote heart health

It is believed that L-THP promotes cardiovascular health. This experimental compound has been shown to activate the KATP channel, which then promotes angiogenesis (blood vessel growth) by regulating the sequence of citrulline-to-arginine flux, arginine biosynthesis, and VEGFR2 expression in endothelial cells. [R] [R]

This potential application still needs more studies. L-THP is not recommended as a safe food supplement to improve one’s heart health.

How Does It Work?

A substantial body of evidence suggests that L-Tetrahydropalmatine binds to dopamine D1 and D2 receptors. L-THP binds to the D3 dopamine receptor as well. Given that the D3 receptor has been identified as a target of interest for medications aimed at preventing relapse, blocking D3 receptors could contribute to the putative anti-addiction utility of l-THP.

Frequently Asked Questions

What is tetrahydropalmatine used for?

Tetrahydropalmatine, an isoquinoline alkaloid that is the active ingredient in Corydalis yanhusuo, has potent analgesic properties.

Is L Tetrahydropalmatine safe?

L-Tetrahydropalmatine and its metabolites have dual pharmacological properties in that they act as both D1 agonists and D2 antagonists. Preclinical data from various relapse models show that L-THP and its metabolites have analgesic and anti-addiction effects without impairing locomotor function.

Despite such purported medical effects, L-THP is classified as a research chemical and should not be used for regular human consumption.

Where can you buy L tetrahydropalmatine?

PureRawz is the best place to buy the highest-quality L-THP online. Our online store is home to several peptides and nootropics that are all safe for research studies.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.

We sell liquid, powder, and capsule high-quality TUDA formulations. All the formulations are equally high-quality.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.
All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

7 reviews for L-Tetrahydropalmatine (L-THP)

  1. Jonathan White

    Feeling great since using this product.

  2. W Patel

    I got my delivery today. Thanks to your fantastic team!

  3. Randy Perry

    This product is one of the most effective sleep aids I have found. Stacked with melatonin and used with the appropriate dosage, this stuff can put anyone to sleep, I’m sure. Also, it doesn’t have any after effects that I could notice.

  4. Danny Houston

    Amazing. The dosage they suggest is the safety dose. 10g was a relaxing and smooth transition from consciousness to a deep and restful sleep.

  5. Lucas Huel

    Thanks to your team for answering all my questions.

  6. John Ramirez

    Seeing a difference!

  7. Titus Schmitt

    Great company! I always get my L-THP here! Great service and fast shipping. Great quality product too! Thanks guys! Five Stars!!! 😊👍

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