Leptin 22-56 – Product Information
Leptin 22-56 (human) regulates energy homeostasis, neuroendocrine function, and metabolism. Leptin deficiency is a clinical syndrome associated with distinct phenotypes, which encompass a very small subset of obesity, hypothalamic amenorrhea, and lipoatrophy. [R]
Recombinant human leptin is an emerging potential therapy for these leptin-deficient conditions. Leptin is secreted mainly by white adipose tissue, and levels are positively correlated with the amount of body fat. The focus of further studies should be identifying new mechanisms of leptin regulation at the whole-body level to design new compounds to potentially reverse leptin resistance.
- Leptin 22-56 is offered in 2mg lyophilized powder.
|Leptin -22-56 Peptide|
What is Leptin 22-56?
Leptin is an endogenous peptide that interacts with leptin receptors and plays a role in energy homeostasis and eating habits. Additionally, Leptin has demonstrated neuroprotective, antihypertensive, and anorexigenic properties. This can be due to the Melanocyte-stimulating hormone (MSH) and gonadotropin-releasing hormone (GnRH) that are secreted as a result of leptin (GnRH). [R]
How Does Leptin 22-56 Work?
Specific leptin receptors (ObRs), which are present in both peripheral tissues and the brain, bind to leptin to mediate its actions. The ObR gene can be spliced to produce several isoforms. Leptin is believed to be transported across the blood-brain barrier through the ObRa isoform (the short leptin receptor isoform). [R]
The hypothalamus, a crucial region for the control of energy balance and neuroendocrine function, exhibits a significant expression of the ObRb isoform (the long leptin receptor isoform), which mediates signal transmission. [R][R]
Leptin 22-56 Research Use
Following is a summary of the existing clinical, animal, and cell-based research on Leptin 22-56. The information presented in this section is for educational purposes only and doesn’t constitute medical advice. PureRawz sells Leptin 22-56 for laboratory and research activities only.
Leptin as an Obese Gene Peptide
A 2015 research review confirmed that Leptin can reverse leptin deficiency-induced obesity and may be helpful in treating lipodystrophy, but it cannot treat ordinary obesity. The hope for leptin’s use as an effective treatment for typical obesity is revived by the development of novel methodologies and drug combinations that may increase leptin’s efficacy and safety. New mechanisms and pathways implicated in leptin resistance are regularly uncovered. [R]
Leptin and Bone Growth Factor
A recent study examined how leptin enhanced the amount of IGF-I receptor messenger RNA (mRNA) and IGF-I receptor in the chondrocyte and progenitor cell populations. These findings suggest that leptin has a direct peripheral influence on skeletal growth centers and functions as a skeletal growth factor.
Findings suggest that leptin has a direct peripheral influence on skeletal growth centers and functions as a skeletal growth factor. Its effects on the developing bone may be partially mediated through the IGF system, which does so by controlling the expression of the IGF-I receptor. The study hypothesizes that obese children’s high levels of leptin in the blood may be a factor in their rapid growth. [R]
Leptin and Hemodialysis Co-Morbidities
Anorexia, hypogonadism, and anemia are prevalent in Hemodialysis patients. Leptin (22-56), a biologically active fragment of Leptin, may have important physiological significance in these Hemodialysis patients. Leptin (22-56) increases both the proliferative activity of normal myometrium and myoma cells in primary culture at doses of 10(-7) and 10(-6) M. [R]
What are normal Leptin levels?
Leptin level normal value ranges may differ slightly between laboratories. If you have any questions regarding your results, be sure to consult the list of typical values included in your laboratory report or consult with your healthcare professional.
Leptin levels should generally fall within the following ranges:
- 0.5 – 15.2 nanograms per milliliter (ng/mL) for adults who were given the gender “female” at birth.
- Adults who were born as males: 0.5 to 12.5 ng/mL.
What is Leptin Resistance?
The brain doesn’t react to leptin as it should if a subject has leptin resistance. This leads to not experiencing fullness or satiety since leptin constantly stimulates hunger. Despite the fact that the body already has considerable fat reserves, this increases consumption and food intake.
The body goes into starvation mode because leptin resistance appears to have low levels of leptin. The brain lowers energy levels and causes a reduction in the amount of calories burned while at rest, in an effort to conserve energy. This is often referred to as diet-induced obesity.
As a result of increasing hunger and slowing metabolism, leptin resistance exacerbates obesity and leads to extra weight gain in the form of fat storage.
Currently, researchers are striving to create medications that can combat leptin resistance.
Where to Buy Leptin 22-56?
PureRawz is the best place to buy Leptin 22-56 online.
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