NRC (Niagen Nicotinamide Riboside)


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NRC (Niagen Nicotinamide Riboside) – Product Information

What is NRC?

Nicotinamide Riboside Chloride (NRC) is a source of niacin and a precursor to nicotinamide adenine dinucleotide (NAD+), which is involved in various metabolic pathways in the body. NRC has potential benefits for immune function, metabolic health, anti-aging, and DNA repair.

CAS Number 1341-23-7
Molar Mass 255.25 g/mol
Chemical Formula C11H15N2O5+
IUPAC Name 3-Carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium

How It Works

Nicotinamide Riboside Chloride (NRC) plays a pivotal role in enhancing our cellular functions by serving as a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme in the bodies of research subjects. When subjects consume NRC, it is converted into nicotinamide riboside (NR), which is then further transformed into nicotinamide mononucleotide (NMN). These conversions are essential steps in the production of NAD+.

NAD+ is like a cellular powerhouse, especially in our mitochondria, where it facilitates the conversion of nutrients into energy. Additionally, NAD+ acts as a cofactor for enzymes involved in metabolic processes and DNA repair. By supplementing with NRC, the goal is to elevate NAD+ levels, potentially leading to improved energy metabolism, more efficient DNA repair, and enhanced cellular processes related to health and longevity. [R]

NRC Research

Numerous studies have been conducted on the potential application of NRC. Below are some of the relevant findings on mushroom products:

NRC on Alzheimer’s Disease

In recent research, scientists have been investigating the potential of nicotinamide riboside (NR) as a promising tool to combat age-related cognitive decline. NR is a precursor to an essential molecule called nicotinamide adenine dinucleotide (NAD+), vital for various cellular functions. Animal studies have shown that oral NR supplementation can enhance memory and learning, making it especially relevant in conditions like Alzheimer’s disease. NR appears to inhibit Alzheimer ‘s-related markers in the brain, reduce DNA damage, lower brain inflammation, and improve nerve cell connections, particularly in diabetic and Alzheimer’s disease mouse models. It also seems to play a role in preventing the production of harmful substances linked to Alzheimer’s disease.

While these findings are exciting, it’s important to note that most of this research has been conducted in animal models. To validate these potential benefits, further clinical trials involving humans are necessary. Nonetheless, oral nicotinamide riboside has demonstrated good tolerance and minimal side effects in human studies compared to other NAD+ precursors. This suggests that NR could hold promise in addressing cognitive decline associated with aging and neurodegenerative diseases like Alzheimer’s, pending additional research to confirm its effectiveness in humans.

NRC on NAD+ levels

NAD+ is like a little powerhouse molecule inside our cells that helps with various important functions. NR Chloride seems to have the potential to enhance NAD+ levels, which, in turn, could offer protection against a range of health issues like neurodegenerative diseases, diabetes, and even hearing loss. Scientists have been studying NR Chloride and its effects on our bodies, and the results are fascinating. It’s not a magic cure, but it’s opening doors to a better understanding of our biology and potential ways to combat diseases. While it’s essential to remember that NR Chloride is for research only, it’s exciting to see where this discovery might lead us in the future. [R]

NRC on Dilated Cardiomyopathy

Nicotinamide Riboside Chloride (NR Chloride) has shown potential benefits in preserving cardiac function, as suggested by a study conducted on mice with dilated cardiomyopathy (DCM). In DCM, the heart struggles to pump blood efficiently, leading to heart failure. Researchers have found that levels of nicotinamide adenine dinucleotide (NAD+), a key coenzyme in energy production, decrease in the failing heart. In the study, mice with DCM and reduced NAD+ levels were given NR Chloride supplementation in their diet. The results were promising. NR Chloride helped maintain NAD+ levels in the heart and improved cardiac function. This suggests that NR Chloride could potentially be used as a treatment option for heart failure, especially in cases like DCM, where treatment options are limited.[R]

It’s important to note that this research is focused on understanding the effects of NR Chloride at a scientific level and is not intended for human use at this stage. Further studies and clinical trials are needed to determine its safety and effectiveness in chronic disease or metabolic disorders.

NRC on Preconception Care

It is known that NRC shows the potential to enhance NAD+ levels. Researchers have discovered that a substance called nicotinamide adenine dinucleotide (NAD+), when given to pregnant mice during a specific time in their baby’s development, can have a remarkable impact on brain health. They used mice with faulty blood vessel cells in their brains to mimic certain aspects of psychiatric diseases. The NAD+ treatment helped fix these blood vessels, improve brain development, and prevent abnormal behaviors in the baby mice.

This exciting discovery shows that NAD+ can play a vital role in shaping the brain’s development before birth. It helps repair blood vessels and ensures that the brain develops correctly. This could have significant implications for improving mental health outcomes, as it provides a way to enhance brain blood flow and potentially prevent mental health issues from developing in the future. While this research is still in the early stages and not meant for human use yet, it opens up an extensive range for better understanding and treating psychiatric diseases.

NRC and Overall Health

Nicotinamide Riboside Chloride (NR Chloride) is a compound that has been studied extensively for its potential health benefits. While it may sound complex, let’s break it down into simpler terms. Bodies need a molecule called NAD+ to function properly, and when there’s not enough of it, it can lead to various health problems like neurodegenerative disorders, heart issues, obesity, and diabetes. NR Chloride is a form of a substance called nicotinamide riboside, and it can boost NAD+ levels. Think of it as a kind of vitamin that could potentially help keep bodies in good shape.

One challenge with NR Chloride is that it can be a bit delicate, and it doesn’t always stay stable during production and storage. Scientists have found a way to make it more stable by combining it with something called borate. However, once you take NR Chloride, the borate part separates and doesn’t do much, while the NR Chloride gets to work in the body of subjects just like it should.

In simple terms, NR Chloride is like a helper in the body, supporting overall health. It’s important to remember that NR Chloride is primarily used for research purposes, not for direct human consumption. Scientists are still working to understand all the ways it can benefit us, so we’ll have to wait for more research before it becomes a mainstream supplement [R]

Where to Buy NRC Online

At PureRawz, your number-one source for buying Nicotinamide Riboside Chloride online, we have, a high degree of commitment to excellence. Our product is the gold standard, providing an equivalent number of benefits for your research needs. Available in oral powder for extemporaneous compounding on your research. Some also offer this product vegan friendly in combination with pharmaceutical-grade, therapeutically active nutritional supplements, with allergens like magnesium stearate and tree nuts.

In order to produce quality items, we provide reference materials with every product we sell. Each of our compounds comes with an independent, lab-tested Certificate of Analysis for identification, purity, and concentration. In the customer review section, you can find reviews from satisfied customers, and you also have the option to share reviews.

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Nicotinamide Riboside Chloride (NRC) is a compound with exciting potential benefits for health. It’s a source of niacin and a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a vital molecule in our bodies. NRC may support immune function, metabolic health, anti-aging, and DNA repair. While research on NRC is promising, it’s important to note that it’s intended for research purposes only, not for direct human use. Potential side effects include nausea, fatigue, headaches, and skin issues. NRC is opening doors to understanding our biology better and may offer ways to combat diseases in the future


This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and read research from Trusted Sources before making any purchase based on your own personal circumstances. You should independently add research and verify any information that you find on our Website and wish to rely upon.

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