P21 (P021)

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Description

P21 (P021) Peptide – Product Information

P21, also known as peptide 21, is a synthetic peptide that has garnered attention for its potential role in neurogenesis and cognitive enhancement. It is researched for its potential to stimulate the growth of new neurons in the brain, potentially leading to improvements in memory, learning, and overall brain function.

P21
CAS Number 1394011-91-6
Molar Mass 578.3
Chemical Formula C20H18ClF6N3O
IUPAC Name 1-[(2-hydroxynaphthalen-1-yl)disulfanyl]naphthalen-2-ol

 

What is P21 Peptide?

P21 or P021 is a synthetic peptide structurally similar to the human protein p21, a cell cycle inhibitor protein that regulates cell growth and division. The peptide is derived from the P6 Peptide, thus also referred to as peptide six fragments. The P21 peptide is an 11-mer peptide that shows excellent neurotrophic and neurogenic qualities in various experimental models [R]. Because of its small size and pharmacokinetics similar to P6, P21 may easily cross the human blood-brain barrier (BBB). It also does not have the adverse effects of natural CNTF or BDNF molecules, making it appropriate for oral administration. Several preclinical investigations have demonstrated the potential therapeutic effects of P021 in the treatment of cancer, AD medication development, and anti-inflammatory agents [R]

How P21 works

The P21 peptide has considerable neurotrophic and neurogenic effects through numerous routes of action. Its ability to cross the blood-brain barrier and function at nanomolar concentrations makes it especially appealing for neuroscience drug development. Inhibiting the active neurogenesis repressor Leukemia Inhibitory Factor (LIF) is one of P21’s primary roles. P21 binds to the D1 cap region of the LIF receptor to suppress LIF signaling, which helps neural progenitor cells mature into adult neurons. Furthermore, P21 promotes the expression of critical neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor. These variables are required for neuronal survival, differentiation, and synaptic plasticity, resulting in an environment that promotes new neurons’ growth, maturation, and integration into existing brain networks. [R]

P21 Peptide Research

Numerous studies have been conducted on the potential application of P21 Peptide. Below are some of the relevant findings on P21 Peptide benefits:

P21 on Cognitive Performance

The P21 peptide’s potential neuroprotective and neurogenic qualities have been linked to considerable gains in cognitive capacities, as proven by several behavioral types of research. One supporting research was the in vivo treatment of the P21 peptide. Mice treated with the peptide were subjected to spatial reference memory tests, such as the Morris Water Maze. The mice demonstrated superior memory recall and navigational abilities compared to the control groups. This study’s results indicate a direct connection between the positive effect of the peptide on activity and cognitive function.

The improved performance of the treated mice suggests that P21 not only has the potential to improve neuronal growth and survival but also converts these biological effects into demonstrable cognitive benefits [R].

P21 on Autism

As a P6 fragment, P21 may also be a potential therapeutic compound for autism. One particular study done to prove this claim was the in vivo testing of Wistar rats injected with autism sera hours after birth alone, while the other group was treated with the protein fragment. In comparison with the untreated group, the treated rats demonstrated significant neurobiological changes compared to the sera-treated only group. The P6-treated mice also showed improved behavioral autistic phenotypes [R].

P21 on Neurodegenerative Disorders

Due to its diverse mechanism of action, P21 could potentially reverse neurodegenerative diseases like Alzheimer’s [R], Parkinson’s, and Huntington’s. These conditions often cause neuronal death, synaptic dysfunction, cognitive impairment, and motor control loss. For probable compounds for such diseases, the P21 peptide’s ability to induce regeneration, preserve neuronal architecture, and improve cognitive performance is essential [R].

P21 Regenerative Capacity in Traumatic Brain Injury (TBI)

TBI can cause long-term cognitive, emotional, and functional issues. The P21 peptide has demonstrated significant potential for reducing the effects of TBI by enhancing the body’s natural healing mechanisms. In animal models of mild to moderate TBI, injection of the P21 peptide has been shown to boost neuronal differentiation, prevent neuronal death, and maintain dendritic and synaptic density in the hippocampus, ultimately leading to improved cognitive performance [R]

Aside from its neurogenic effects, P21 also serves a vital role in maintaining the complicated neuronal architecture of the hippocampus, a brain region necessary for cognitive functioning. Continuous P21 injection dramatically reduced dendritic and synaptic density loss in TBI models. This reduction preserved hippocampal neuron structure and function. [R]

P21 on Potential Applications in Regenerative Medicine

Due to P21’s promising P21’s therapeutic targets, researchers continue to investigate the peptide’s ability to stimulate tissue regeneration in a variety of additional settings, including wound healing, bone regeneration, and cardiac repair.

In wound healing, the P21 peptide promotes keratinocyte proliferation and migration, the epidermis’ most frequent cell type. An increased basal proliferation rate may speed tissue regeneration of chronic wounds, burn injuries, and other skin conditions [R]. Similarly, in bone regeneration, the P21 peptide demonstrated its potential to increase the differentiation and maturation of osteoblasts, the cells responsible for bone formation [R]. This trait could also be used to pave new therapeutic approaches for bone loss problems such as osteoporosis, fractures, and bone deformities.

FAQs

What is another name for the P21 peptide?

The name Ac-DGGLAG-NH2 is another name for P21.[R]

How are Cerebrolysin and P21 related?

P21 vs cerebrolysin are sometimes compared, so how are they related? Cerebrolysin is a brain-derived drug that contains unique peptides that improve memory and cognitive function. Peptide 6c, one of these peptides, has been enhanced and transformed into P21, which enhances its ability to penetrate the brain and withstand breakdown. P21 increases the proteins involved in brain communication, promotes the creation of new brain cells, and improves cognitive abilities in mice [R]

Are P21 Peptide and P21 (CDKN1A) the same?

While the names may seem similar, the P021 synthetic peptide is being investigated for its possible advantages in brain regeneration and growth. At the same time, the p21 (CDKN1A) protein is connected to cell cycle regulation and death.

Is P21 Peptide safe?

Research has shown that P-21 peptide may have benefits beyond those already mentioned. There is no solid proof of short-term advantages from utilizing P21 Peptide, and the potential long-term consequences are also unclear. Purerawz sells P21 Peptide for research purposes only.

Where to Buy P21 Online?

P21 Nootropic Peptide can be purchased online, most conveniently at PureRawz. We provide a large selection of premium peptides and nootropics to guarantee that you get the best goods.

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Conclusion:

The neurotrophic and neurogenic properties of synthetic peptide P21 render it a promising treatment for degenerative and neurological diseases. Its therapeutic potential is enhanced by its ability to penetrate the blood-brain barrier and operate at nanomolar concentrations. P21 can promote neuron growth, differentiation, and survival by inhibiting LIF signaling and increasing BDNF. It has been shown in experimental animals that it has the potential to treat neurodegenerative disorders, severe brain injuries, and autism and promote tissue regeneration.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with the appropriate Institutional Review Board (IRB) oversight. All preclinical research must be conducted with oversight from the relevant Institutional Animal Care and Use Committee (IACUC) following the Animal Welfare Act (AWA) guidelines.

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