Description

Palmitoylethanolamide (PEA) – With Levagen Capsules – Product Information

Palmitoylethanolamide, or PEA for short, is a chemical made from fat. It is produced endogenously in the human body and is found naturally in foods such as egg yolks and peanuts. Research has shown that the body produces increased amounts of PEA in disease states.

PEA has proven anti-inflammatory, anti-microbial, and neuroprotective effects. It has also exhibited the potential ability to bind to body cells and reduce pain and swelling. In clinical trials, PEA reportedly reduced sleep disturbances, enhanced joint health, and boosted recovery from injury.

• Palmitoylethanolamide (PEA) – With Levagen Capsules are offered as 300mg per capsule for 60 capsules, totaling 18g.

PureRawz sells Palmitoylethanolamide for laboratory and research use only.

What is Palmitoylethanolamide?

Palmitoylethanolamide is a fatty acid amide produced in the body. Fatty acid amides are a group of nitrogen-containing, lipid-soluble fatty acid derivatives. They exert control over locomotion, sleep, angiogenesis, and many other crucial processes in the body. [R]

PEA can be found naturally in various foods, such as egg yolks, peanuts, soybeans, alfalfa, and lecithin. Many animals and plants also produce PEA. It was first discovered in the 1950s and has attracted various randomized clinical trials and preclinical studies since then. [R]

These studies have shown that PEA could reduce complex pain. PEA has also demonstrated the ability to expedite recovery from stroke, reduce eye nerve damage, and improve mood. This substance may enhance the quality of life in patients with multiple sclerosis. [R][R][R]

In addition to exerting the above effects, PEA has established an excellent clinical and preclinical safety record. That is because, unlike other endocannabinoids, its catabolism gives rise to those products (palmitic acid and ethanol amine), that do not produce side effects. [R]

How does Palmitoylethanolamide Work?

These are the proposed mechanism(s) of action of PEA:

Activates PPAR Alpha

PPAR alpha is an energy-boosting, fat-burning, and anti-inflammatory protein. PEA activates this key protein to stop the production and activity of many inflammatory substances. This, in turn, enables PEA to potentially improve overall body health. [R]

Reduces FAAH Activity

FAAH (fatty acid amide hydrolase) is a protein-coding gene. It breaks down anandamide, an enzyme that helps the body calm down by combating pain and increasing relaxation. Thus, by reducing FAAH activity, PEA enables anandamide to carry out its functions effectively. [R]

Interacts as an Agonist with GPR119

GPR119 is a G protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract. In vitro studies and animal models suggest that its modulation may produce favorable effects on food intake, glucose homeostasis, and body weight gain. [R]

Palmitoylethanolamide Research

What follows is a summary of existing clinical and preclinical research on PEA. The information given in this section is for educational purposes only and doesn’t constitute medical advice. Speak to a qualified health physician if you have any suspected medical conditions.

PEA and Pain Relief

An overwhelming body of evidence backs the ability of PEA to provide pain relief. Over 30 clinical trials involving more than 6,000 subjects have investigated the effects of this fatty acid on chronic pain as well as severe pain. Here’s what these trials have reported:

• Pelvic pain caused by endometriosis in women. In a clinical trial involving 56 women, PEA treatment (300 mg/day for 6 months) relieved pain, improved sexual function, and enhanced the quality of life. [R]
• Sciatica pain that doesn’t respond to painkillers. In an open study involving 20 non-responders to previous treatments, a combination of PEA and Oxycodone treatment significantly decreased sciatica pain. [R]
• Nerve Pain caused by carpal tunnel syndrome. A study conducted to investigate the effects of PEA treatment in diabetic patients affected by CTS reported a reduction in neuropathic pain vis-à-vis PEA and the control group. [R]
• Pain associated with knee osteoarthritis. In a double-blind, placebo-controlled study, PEA demonstrated the ability to attenuate pain and reduce other related symptoms of knee osteoarthritis. [R]

In addition to the above effects, PEA has been shown to potentially relieve cancer pain. It also supports relief from other pain states, including pain from a failed back surgery and muscle pain caused by fibromyalgia.

Equally important, none of the above studies reported any side effects. [R]

PEA and Neuroprotection

According to a clinical trial involving sufferers of acute ischemic stroke (the leading cause of permanent disability in adults worldwide), a formulation of PEA with luteolin improved recovery. It also enhanced the subjects’ cognitive skills, overall brain health, and daily functioning. [R]

In a cell model of amyloid-beta (AB) neurotoxicity, PEA treatment induced significant neuroprotection by reducing infiltrating astrocytes during the AB challenge. This demonstrated PEA’s ability to reduce AB-evoked neuro-inflammation and attenuate its neurodegenerative consequences. [R]

Finally, a clinical review of in vitro and in vivo data suggested that PEA, especially in its ultra-micronized formulation, exerts robust therapeutic effects in animal models of Alzheimer’s disease. Ultra-micronized forms are those that maximize PEA’s bioavailability and efficacy. [R]

PEA and Glaucoma

Glaucoma is the second leading cause of blindness worldwide. Research shows that high eye pressure (intraocular pressure or IOP) increases your risk for glaucoma. [R][R]

In a randomized, double-blind, crossover clinical trial, 42 patients with raised IOP received oral PEA or placebo for 2 months. Results compiled after a 2-month washout period indicated that PEA treatment reduced IOP by significant amounts vis-à-vis placebo. [R]

Another study reported that PEA treatment for 3 months significantly reduced IOP in naïve ocular hypertensive patients. The positive effects lasted longer than the period of PEA consumption. Equally importantly, no side effects were reported. [R]

PEA and Depression

A 2018 study set out to investigate the effects of PEA in patients with major depressive disorder. Fifty-eight patients with MDD were randomized to receive PEA (600 mg twice/day) or a placebo, in addition to citalopram (antidepressant), for six weeks. [R]

Results from the study show that PEA adjunctive therapy to citalopram can effectively improve symptoms of depression in patients with MDD. A higher number of patients in the PEA group responded to the treatment (100%) than those in the placebo group (74%). [R]

PEA and Multiple Sclerosis

The effects of solo PEA on multiple sclerosis (MS) are yet to be explored.

When administered as an add-on to conventional MS therapy, oral palmitoylethanolamide supplement reduced the disease’s adverse effects and pain in a trial of 29 subjects with rapidly advancing MS. The fatty acid amide was also associated with an increased quality of life and cognition. [R]

PEA and Sleep

According to a double-blind, placebo-controlled study, PEA is a potential sleeping aid capable of reducing sleep onset time and improving cognition on waking. The study was conducted on healthy adults with sleep pattern disturbances. [R]

Another study reported that PEA treatment (600 mg twice daily) significantly improved overall sleep quality in patients awaiting carpal tunnel syndrome surgery. There was an increase in continuous sleep time and reduced sleep disturbances. [R]

Frequently Asked Questions

What is the half-life of PEA?

Palmitoylethanolamide amide has a half-life of about 25 minutes.

Where to Buy Palmitoylethanolamide Online?

PureRawz is the best place to buy the highest-quality PEA online.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. We sell liquid, powder, and capsule high-quality TUDA formulations. All the formulations are  equally high-quality.

Summary

Palmitoylethanolamide is a fatty acid amide produced in the body. In various clinical trials, it has demonstrated anti-inflammatory, neuroprotective, and pain management effects. PEA has also shown the ability to improve eye health, enhance sleep quality and alleviate depression symptoms.