Picamilon Sodium (Nicotinoyl-GABA)

(7 customer reviews)

$21.98

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Description

Picamilon Sodium (Nicotinoyl-GABA) – Product Information

Picamilon is a nootropic compound clinically used in Russia for the potential treatment of stress, anxiety, and other neurological conditions. It is made of the inhibitory neurotransmitter GABA and vitamin B3 (Niacin) and may potentially cross the blood-brain barrier that GABA alone cannot.

Various preclinical studies have shown that Picamilon may potentially reduce anxiety- and depression-related behavior improves short- and long-term memory, and prevents neurons’ excitotoxicity. Additionally, it may increase blood flow to the brain and protect against nerve inflammation.

  • Picamilon Dosium is offered as 5g powder.

PureRawz sells Picamilon for laboratory research use only.

Picamilon Sodium NICOTINOYL-GABA
CAS Number 34562-97-5
Molar Mass 208.217 g/mol
Chemical Formula C10H12N2O3
IUPAC Name 4-(Pyridine-3-carbonylamino)butanoic acid

PureRawz sells Picamilon for laboratory research use only.

What is Picamilon?

Picamilon is a nootropic that was originally developed in the USSR to potentially enhance GABA activity in the brain. It is a prescription compound in Russia for potentially treating various neurological conditions, such as stress and anxiety. Picamilon is not approved as a compound in the US. [R][R]

Picamilon is a combination of gamma-aminobutyric acid (GABA) and nicotinic acid (vitamin Niacin). GABA is a neurotransmitter that sends chemical messages through the brain and nervous system. While Picamilon can potentially cross the blood-brain barrier, GABA alone cannot. [R]

Niacin is a vitamin (vitamin B3) that plays a vital role in DNA repair and fat and cholesterol synthesis. In addition, Niacin acts as a vasodilator. Niacin is found in many natural foods, including fish, beef, and seeds. Unlike GABA, it is not produced inside the body. [R]

The combination of Niacin with GABA is the reason why Picamilon can potentially penetrate the blood-brain barrier and produce the effects attributed to this nootropic.

However, without randomized clinical trials, one cannot be entirely sure about its safety and efficacy.

How does Picamilon Work?

Preclinical studies report that if Picamilon were to enter the brain, it would be broken down into its two components, GABA and niacin. GABA is thought to activate GABA receptors (A and B types), while niacin reportedly dilates blood vessels to increase blood flow throughout the brain. [R][R]

Picamilon has been found to potentially improve cerebral blood flow in animals. There is evidence of the nootropic activating GABA receptors to reduce anxiety- and depression-related behavior in rats.

Picamilon has also been shown to potentially increase blood flow in the brain more than piracetam. [R][R][R]

Picamilon Research

What follows is a summary of the existing clinical, animal, and cell-based research on Picamilon. The information given in this section is for educational purposes only and be constituted medical advice. Pure Rawz doesn’t sell Picamilon for human consumption.

Picamilon and Vision Disorders

Macular degeneration is an eye disorder that can blur your central vision.

In a clinical study involving 60 patients with macular degeneration, three months of Picamilon treatment potentially improved visual acuity (sharpness of vision) in some patients. The patient’s ability to see out of the corner of their eyes (visual field) also potentially improved. [R]

Another study investigated the effects of Picamilon on central chorioretinal dystrophy, a condition that results in progressive vision loss. Forty-eight patients were enlisted for the study. Picamilon reportedly improved their visual acuity and peripheral vision and reduced glaucoma severity. [R]

Picamilon and Cerebral Blood Flow

Cerebral blood flow, or blood flow in the brain, is crucial for your health. If it becomes impaired, serious health issues may arise, including a stroke.

Multiple preclinical studies have shown that Picamilon potentially improves blood flow throughout the brain. The first of those studies, which was carried out in 1989, reported that the compound may potentially improve blood flow more than two other nootropics, one of which is piracetam. [R]

A recent animal study on the effects of Picamilon on cerebral blood flow was conducted in 2005. Findings from the study reveal that Picamilon’s potential ability to increase blood flow in the brain may depend on the nootropic activating the chloride channels of the GABA receptors. [R]

Picamilon and Anxiety and Depression

According to an animal study, Picamilon reduced anxiety- and depression-related behaviors in rats – apparently by activating GABA-A receptors. GABA is the chief inhibitory neurotransmitter in the brain. It counteracts the action of glutamate, an anxiety-causing neurotransmitter. [R][R]

In another preclinical study, Picamilon was found to suppress the animals’ responses to disturbing stimuli. The nootropic was also reported to delay the mice’s response to such stimuli, suggesting a potential though not proven diminished anxiety response. [R]

Picamilon and Memory

Only one preclinical study has examined the effects of Picamilon on memory. Findings obtained by the study reveal that Picamilon potentially improved short- and long-term memory. Additionally, the nootropic was found to enhance the animals’ navigation ability. [R]

It is to be noted that Picamilon was solely responsible for only one of these effects – improvement in short-term memory. All the other effects were brought about by the combination of this compound, piracetam (another nootropic), and tacrine (medication for mild to moderate dementia).

Picamilon and Neuroprotection

In one preclinical study involving rats, Picamilon exhibited the ability to protect brain cells from being over-activated to the point of death (excitotoxicity). Aside from that, the nootropic also increased mitochondrial function in the neurons of rats with brain trauma. [R]

Additionally, in another animal study, Picamilon exhibited the ability to protect the immune and brain cells of sleep-deprived rats. It apparently did that by reducing oxidative stress and shielding the membranes of the brain cells from getting damaged. [R]

Lastly, a preclinical study examined the effects of Picamilon on those regions of the brain that are proven to be related to the development and progression of Parkinson’s disease. It was found that Picamilon potentially brought serotonin and dopamine to normal levels. [R]

Picamilon and Diabetic Neuropathy

Diabetic neuropathy refers to a condition in which diabetes causes nerve damage. Its symptoms can range from numbness in the feet to problems with internal organs. Research suggests that up to one-half of people with diabetes have this condition. [R]

In an animal study, Picamilon reduced inflammation of nerves in mice with this condition. This was accompanied by a partial reduction of brain sorbitol level. These findings confirm the important role of the nootropic in potentially preventing and treating diabetic neuropathy. [R]

Picamilon and Disadaptation Syndrome

Dysadaptation syndrome is characterized by disequilibrium in a sitting and standing position. It leads to gait modifications, alters postural reactions, and heightens the fear of falling. [R]

A preclinical study explored the effects of phenibut, aminalon, and picamilon treatment on swimmers with disadaptation syndrome. Results from the study indicate that the compounds potentially produced a decrease in the blood filling of the brain. Plus, they potentially increased blood flow from the brain. [R]

Frequently Asked Questions

Is Picamilon Legal?

Picamilon is not approved for use by the FDA. It is illegal to include it in dietary supplements.

Does Picamilon Induce Muscle Relaxation?

No clinical or even preclinical evidence supports this hypothesis.

Picamilon Side Effects

Early evidence from clinical studies indicates that Picamilon is safe and isn’t toxic. The effects that have been reported so far may include headache, dizziness, nausea, and skin flushing. Plus, Picamilon may lower blood pressure at high doses, making it unsafe for those with already hypotension. [R][R][R]

Where to Buy Picamilon?

PureRawz is the best place to buy Picamilon online.

In order to be the best supplier of research peptides, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.

Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

Picamilon Summary

Picamilon has demonstrated the potential ability to alleviate several vision disorders. In preclinical studies, the nootropic exhibited the potential to reduce anxiety and depression, boost blood flow in the brain, and improve short- and long-term memory.

7 reviews for Picamilon Sodium (Nicotinoyl-GABA)

  1. Debby Read

    Good product, it really works.

  2. Billy Cox

    I decided to make a change and start fixing the underlying cause of my anxiety, and with Picamilon I am able to do so.

  3. Robert

    Another good product! Highly recommended because first, it is very affordable. Second, I’m always in a good mood.

  4. Anonymous

    Great service!

  5. Domingo Harper

    I’m forever grateful for the calmness I feel! I cannot function without this.

  6. R Sanchez

    This has been working well for me so far. I have clearer thinking and memory.

  7. Lowell Bartoletti

    So happy that they ship to my new shipping address as requested. I’ve ordered many times from this company and they always come through. Also, their products are very good, I highly recommend them.

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