Pyrroloquinoline Quinone (PQQ)

Description

What is Pyrroloquinoline Quinone (PQQ)?

Pyrroloquinoline Quinone (otherwise, PQQ) is a redox-active quinone compound. It occurs in soil, certain foods, and bacterial cultures. This vitamin-like molecule functions as a cofactor for various enzymatic reactions. The mentioned role is observable in prokaryotes and is of interest in biochemical and cellular research.

What’s the mechanism of action of Pyrroloquinoline Quinone (PQQ)?

Among research models, PQQ exhibits the following biochemical characteristics:

• Redox Cycling: PQQ may undergo multiple cycles of oxidation and reduction without significant degradation. This action enables the chemical to participate repeatedly in the electron transfer process.
• Enzyme Cofactor Activity: The understudy may also act as a cofactor for certain bacterial dehydrogenases. These are commonly involved in metabolic oxidation reactions.
• Cell Signaling Modulation: As observed in research, PQQ may also influence gene expression related to mitochondrial function in certain model systems.

What are the potential benefits of Pyrroloquinoline Quinone (PQQ)?

PQQ is utilized in research environments to investigate the following possible effects:

Inflammation and oxidative-stress biomarkers

A small number of studies report reductions in systemic inflammatory markers (e.g., C-reactive protein and interleukin-6) after oral exposure to PQQ. It also resulted in improvements in urinary oxidative-stress markers. [R]

Sleep quality and fatigue

An open-label trial administered PQQ daily for a period of 8 weeks. This supposedly resulted in improvements in subjective sleep-quality metrics (sleep duration and latency) and even in fatigue inventories. Some effects of PQQ were observable at 4 weeks, while others were at 8 weeks. [R]

Mitochondrial biogenesis

Multiple cellular and rodent studies show that PQQ exposure produces the following results:

• Increases phosphorylation of CREB (Ser133)
• Upregulates PGC-1α mRNA and protein
• Elevates the downstream nuclear respiratory factor [R] [R]

Considering these effects, PQQ seems to be able to switch on several signals within cells. Together, these lead to cells making more and healthier mitochondria.

Memory, learning, and the CREB – BDNF axis

Some studies involve rodent models of oxidative stress and cognitive impairment. Here, PQQ administration has been associated with improvements in learning and memory tasks. Cell and animal models also exhibited reversal of deficits induced by neurotoxic means. [R] [R]

Effects on neurotrophic factors and glial/Schwann cell signaling

In vitro studies indicate that PQQ can stimulate nerve growth factor (NGF) production in cultured cells. Similar data also state that this investigational compound may increase markers related to Schwann cell activity. Early animal tests detected NGF levels in rat brains when given certain PQQ derivatives. Such results are suggestive of PQQ’s potential to influence nerve-supporting processes. [R] [R]

Neuroprotection

• DJ-1: Studies show PQQ may lead to an increase in the reduced variant of DJ-1. The latter is a protein implicated in cellular oxidative defense. [R]
• Ischemia/Stroke Models: One study utilized rodent models in which PQQ was administered near the time of the ischemic insult. The outcome involved the reduction in infarct volumes and improvement of short-term neurobehavioral results.

Current Research On Pyrroloquinoline Quinone (PQQ)

• In certain animal studies, giving PQQ before and after a heart attack reduced heart tissue damage and even preserved mitochondrial function. [R] This effect has not been tested among humans.
• Animal research suggests PQQ may improve insulin sensitivity by boosting mitochondrial production in muscles. It is also purported to influence enzymes linked to glucose control. However, human studies are still needed. [R] [R]
• As observed in one study, rats without PQQ had slower metabolisms as compared to those with normal levels. [R] As such, some researchers are convinced that PQQ could raise metabolic rate. It is important to note that this has not been studied in humans.
• Mice deprived of PQQ showed weakened immune responses, while those given PQQ had higher levels of key immune cells. [R] [R] This effect is still unknown to be similar in humans.

What is the best place to buy Pyrroloquinoline Quinone (PQQ)?

In sourcing your PQQ for research, PureRawz is the best online store there is in terms of product reliability and premium customer support. We supply research products that have been verified through independent third-party analysis. Plus, all of our products are provided strictly for research and development purposes. You will also receive a knowledgeable and client-centric customer support team that will efficiently address all types of concerns. We are here for you 24/7.

Is Pyrroloquinoline Quinone (PQQ) legal?

In most jurisdictions, PQQ is only available for laboratory and research use. Regulations differ between countries and regions. Thus, it is the purchaser’s responsibility to verify all applicable laws before ordering.

FAQs

Is PQQ a vitamin or a coenzyme?

PQQ is considered to be a redox cofactor in certain bacterial enzymes. It has vitamin-like activity in some organisms. It is not officially classified as a vitamin for humans.

What is Pyrroloquinoline Quinone used for in research?

PQQ is studied for its possible role as a redox cofactor. It is also being investigated for its involvement in mitochondrial biogenesis and its potential effects on oxidative stress in research models.

Can PQQ reverse aging?

There is no scientific evidence suggesting that PQQ can reverse aging. Although there is some laboratory research stating that it may influence pathways linked to mitochondrial health and oxidative stress. These are associated with aging processes.

Is Pyrroloquinoline Quinone from PureRawz intended for human use?

No. All PureRawz products, including PQQ, are sold strictly for laboratory and research purposes only.

How is the quality of Pyrroloquinoline Quinone from PureRawz verified?

Every batch is subjected to third-party analytical testing. By doing so, PureRawz confirms chemical identity, purity, and compliance with stated specifications.

What is the legal status of Pyrroloquinoline Quinone?

PQQ is generally available for laboratory research use in most regions. However, end users are still responsible for ensuring compliance with local regulations.

IMPORTANT: PureRawz supplies PQQ for research purposes only. This product is not approved for human consumption. Any possible effects of the product should not be construed as a form of endorsement or medical advice.