Description

Reduced Glutathione – Product Information

Glutathione is an essential component of the antioxidant system, which safeguards the body against free radicals at the cellular level. This hormone could be the most abundant intracellular thiol among animal living cells.

Reduced glutathione participates in the synthesis and repair of DNA, as well as the antioxidant activity of vitamin C, amino acid transport, and the detoxification of harmful compounds.

Reduced glutathione is being studied as a potential dietary supplement that could positively affect the human body based on its antioxidant functions aside from promoting skin health. However, this chemical compound is not intended to diagnose, treat, cure, or prevent illnesses.

Adverse reactions occur during the misuse of this experimental drug. Reduced glutathione supplements are not recommended for human consumption.

Reduced Glutathione Peptide
CAS Number	70-18-8
Molar Mass	307.32 g·mol−1
Chemical Formula	C10H17N3O6S
IUPAC Name	(2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid

What is Reduced Glutathione?

Glutathione is a tripeptide (or small protein) with intracellular low molecular weight made up of three amino acids: cysteine, glycine, and glutamic acid (or glutamate). Glutathione, also known as a powerful antioxidant, increases the utilization and recycling of other antioxidants such as vitamins C and E, alpha-lipoic acid, and CoQ10.

Glutathione comes in two forms: reduced glutathione (GSH, or L-glutathione), which is active, and oxidized glutathione (GSSG), which is inactive.

DNA creation and repair depend heavily on reduced glutathione. Additionally, it improves the transport of amino acids, vitamin C’s antioxidant activity, and toxic substances’ detoxification. [R]

Reduced glutathione becomes oxidized and inactive as it patrols the cellular environment and extinguishes oxidative “free radical” fires, transforming into oxidized glutathione.

Fortunately, the glutathione reductase enzyme can recycle inactive GSSG into active GSH.

When this enzyme is overworked, and a large amount of oxidized GSSG accumulates (compared to active GSH), your cells become vulnerable to damage.

Possible Applications of Reduced Glutathione

Reduced Glutathione and Diabetes

Long-term high blood sugar levels are associated with low glutathione levels. This results in oxidative stress and tissue damage. [R]

A study discovered that consuming cysteine and glycine supplements increased glutathione levels. It also reduces oxidative stress and damage in people with uncontrolled diabetes, despite high blood sugar levels. [R]

Reduced Glutathione and Liver Health

Protein, enzyme, and bilirubin levels in the blood of people with alcoholic and nonalcoholic chronic fatty liver disease have been demonstrated to be improved by glutathione.

According to a study, intravenous administration of high doses of glutathione to patients with fatty liver disease had the best results. Malondialdehyde, a measure of liver cell damage, also decreased in research participants. [R]

Reduced Glutathione and Respiratory Disease Symptoms

Asthma and cystic fibrosis are two illnesses that can be treated with N-acetylcysteine. It aids in thinning mucus and making it less paste-like, when inhaled. It lessens inflammation as well. Reduced glutathione supplement could produce N-acetylcysteine as a byproduct. [R]

Further research is still needed to verify this assertion.

Reduced Glutathione and Peripheral Disease

Peripheral artery disease occurs when arteries in the legs become clogged by plaque. [R]

One study found that glutathione improved circulation, allowing participants to walk pain-free for longer distances. [R]

Reduced Glutathione and Oxidative Stress

Oxidative stress occurs when there is an imbalance between the production of free radicals and the body’s ability to combat them. Excessive oxidative stress may be a precursor to a variety of diseases. [R]

Diabetes, cancer, and rheumatoid arthritis are examples. Glutathione helps mitigate oxidative stress effects, which may lead to a reduction in disease. [R]

According to one article, glutathione deficiency causes increased levels of oxidative stress, which may lead to cancer. [R]

It was also stated that increased glutathione levels increased antioxidant levels and oxidative stress resistance in cancer cells. [R]

Reduced Glutathione and Insulin Resistance

A team of researchers investigated the function of glutathione in aging-related insulin resistance and weight management, using a combination of animal and human studies. [R]

When cysteine and glycine were added to the diets of older participants, their levels of reduced glutathione purportedly increased within two weeks, which improved their insulin resistance and fat burning.

Reduced Glutathione and Autoimmune Disease

Based on a clinical study, glutathione either increases or decreases the body’s immune response, which helps alleviate oxidative stress. [R]

Diseases with an autoimmune component damage particular cells’ mitochondria. By scavenging free radicals, glutathione protects the mitochondria of the cell.

How Does Reduced Glutathione Work?

Reduced glutathione is involved in both xenobiotic and endogenous compound detoxification. It promotes cell excretion, body excretion and directly neutralizes many oxidative chemicals. [R]

Glutathione aids in the transport of toxins across the plasma membrane via at least four different mechanisms, the most important of which is the formation of glutathione S-conjugates. [R]

Chronic exposure to chemical toxins and alcohol, cadmium exposure, AIDS/HIV, macular degeneration, Parkinson’s disease, and other neurodegenerative disorders are all linked to low glutathione and transferase activity. [R]

Glutathione scavenges various oxidants, including superoxide anion, hydroxyl radicals, nitric oxide, and carbon radicals. Glutathione detoxifies hydroperoxides, peroxynitrites, and lipid peroxides catalytically. [R]

Another way glutathione protects cells from oxidants is by recycling vitamins such as vitamin C and E. [R]

Frequently Asked Questions

Is reduced glutathione different than glutathione?

The distinction between reduced glutathione and glutathione is minimal. However, there are two different types of glutathione: oxidized glutathione (GSSG), which is inactive, and reduced glutathione (GSH, or L-glutathione), which is the active form.

Glutathione, often referred to as GSH, is a tripeptide molecule composed of three amino acids: glutamate, cysteine, and glycine. It is a vital antioxidant found in cells throughout the body and plays a crucial role in various physiological processes.

The term “reduced glutathione” refers to the active, or reduced, form of glutathione. In its reduced form, glutathione has an extra electron that allows it to readily donate electrons to other molecules and neutralize harmful free radicals. This process helps protect cells from oxidative damage and maintain their proper function.

On the other hand, “oxidized glutathione” refers to the form of glutathione that has lost an electron and is in an oxidized state. Oxidized glutathione can be converted back to reduced glutathione through enzymatic reactions involving glutathione reductase and nicotinamide adenine dinucleotide phosphate (NADPH).

The balance between reduced and oxidized glutathione is essential for cellular redox homeostasis. Maintaining higher levels of reduced glutathione is crucial for optimal antioxidant defense and maintaining overall cellular health.

In summary, glutathione refers to the tripeptide molecule composed of glutamate, cysteine, and glycine, while reduced glutathione specifically refers to the active form with an extra electron that enables its antioxidant function.

How is reduced glutathione available?

Reduced glutathione is typically available in the form of capsules and powder. It is also manufactured using other ingredients, such as magnesium stearate, silicon dioxide, and microcrystalline cellulose. Other brands sell non-GMO reduced glutathione to cater to a vegetarian clientele.

Is reduced glutathione safe?

Reduced glutathione may offer certain health benefits, but this experimental drug is not a recommended food supplement. Further research is needed to determine the conclusive medical effects of reduced glutathione.

What can you stack with reduced glutathione?

Reduced glutathione could work well with L-carnitine. As supported by a specific study, the combination of the two has been demonstrated to protect the plasma membrane in case of oxidative damage, resulting in improved sperm morphology and mobility. [R]

Where can you buy Reduced Glutathione?

Pure Rawz is the best place to buy the highest-quality reduced glutathione online.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. We sell liquid, powder, and capsule high-quality formulations. All the formulations are equally high-quality.