Sarcosine – Product Information
- Sarcosine is offered as 50g powder.
Sarcosine, a metabolite of glycine, is also referred to as N-methylglycine. Although research shows its effects are less potent, it shares characteristics with both glycine and D-serine.
Research shows sarcosine may enhance cognition or even possibly lessen the effects of depression and schizophrenia.
Compared to D-serine, which can also be used to treat related disorders, it is believed to have a more consistent absorption.
|Molar Mass||89.093 g/mol-1|
What is Sarcosine?
Sarcosine is the N-methyl derivative of glycine. It is an organic amino acid that is present in bodily tissues like muscles. It can be created in a lab using methylamine and chloroacetic acid. Sarcosine occurs naturally as a metabolic step between choline and glycine. In addition to other uses, it is utilized in the production of biodegradable surfactants and toothpaste. [R]
How Does Sarcosine Work?
The primary mechanism of sarcosine is the inhibition of the transporters GlyT1 and D-serine entering cells. As a result, the body’s stores of glycine and D-serine grow, amplifying their effects. [R]
Sarcosine has been extensively researched in a variety of fields as a potential supplement. Sarcosine has surprising potential health benefits. Studies over the past two decades uncovered its role in potentially treating mental health disorders, including schizophrenia and depression. Below follows some of the proposed sarcosine benefits:
Sarcosine on Brain Health, Memory, and Learning
Research shows that activity at the glycine binding site of the NMDA receptors appears to boost cognition secondarily to improving NMDA signaling, which has been shown to influence both young and elderly rats, as is evident with synthetic agonists, mice lacking the Gly1T transporter (which sarcosine inhibits) and having greater glycine levels in the synapse, as well as both glycine and D-serine. [R][R][R]
In summary, since sarcosine can directly serve as a coagonist, it is thought that its inhibition of Gly1T underlies the cognitive enhancing effects secondary to rising synaptic levels of glycine and D-serine.
Sarcosine and Schizophrenia
Since agonists of the glycine modulatory site, such as D-serine, are reduced in schizophrenic individuals, it is thought that the reduced NMDA function may be caused indirectly by decreased glycine binding site activity. NMDA signaling is thought to be perturbed in schizophrenic individuals (and antagonists like PCP cause or exacerbate schizophrenic symptoms). [R] [R]
Studies that used sarcosine reported improvements in symptoms in the range of 14–16% (BPRS and PANSS rating scales), reaching up to almost 20% symptom reduction compared to control, with 2,000 mg sarcosine daily for six weeks in addition to antipsychotics. [R]
Sarcosine and Depression
Preliminary research suggests that inhibition of GlyT1 may be a novel treatment for depression and that it may be more effective than the standard treatment, citalopram. [R]
Sarcosine and Addiction
D-serine has been extensively studied for its potential use in treating cocaine dependence, and it appears that this also applies to sarcosine and other agonists at the glycine binding site of NMDA receptors, such as cycloserine. [R]
Sarcosine and Prostate Cancer
Sarcosine may have pro-oncogenic effects without obvious mutagenic effects (promotes cancer growth when present but does not necessarily cause cancer), although the research to date has only been conducted in cell cultures.
This research indicates that Sarcosine appears to be elevated in the urine of persons with prostate cancer and thus potentially useful as a biomarker and also appears to be elevated in the tumor itself. [R]
Although this concept seems plausible, there are currently no animal models to support it.
Sarcosine and OCD
Another mental health condition that causes a lot of distress and frequently interferes with daily life is obsessive-compulsive disorder (OCD). Its defining characteristics are repetitive unwanted thoughts, pictures, and desires until the person feels obliged to act on them in order to calm their worry and uneasiness. [R]
Sarcosine was given either alone or as an additional treatment for 10 weeks to 26 to OCD patients in a trial. Particularly in patients who had not previously received any therapeutic pharmacological treatment before the trial, sarcosine significantly reduced OCD symptoms. [R]
Sarcosine and Anxiety
Additionally, a sarcosine derivative (ALX 5407) reduced nervous behavior in rats experiencing anxiety, caused by mothers being separated from their pups. The decrease was on par with anti-anxiety drugs such as escitalopram and diazepam. [R]
Sarcosine and Strokes
Insufficient blood flow to the brain causes cerebral ischemia, which can lead to a stroke or the death of brain tissue.
Sarcosine pretreatment in rats improved tolerance to blood shortage and decreased brain cell death (hippocampus). Consequently, sarcosine prevented strokes in the brain. [R]
Is Sarcosine Safe?
The danger of sarcosine supplementation is not yet known. It may function as a co-carcinogen, which means it doesn’t directly cause cancer but enhances the effects of other carcinogens. However, further research is required to evaluate the safety and efficacy of sarcosine powder.
Sarcosine can have many potential future implications as a dietary supplement to marvel conventional prescription compounds. Purerawz sells Sarcosine for research purposes only.
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One of glycine’s metabolites is sarcosine, also referred to as N-methylglycine.
Research shows that the potential of a sarcosine supplement may be to enhance cognition or lessen the effects of depression and schizophrenia.
The relationship between sarcosine and prostate cancer is also being extensively researched. Sarcosine levels in the blood may be a biomarker for prostate cancer, which means they may be an indication of the disease if they are greater than usual.