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Semax – Product Information

Semax is a neuropeptide initially developed to treat circulatory disorders such as heart attack, strokes, and high blood pressure. This synthetic peptide was initially developed in Russia in the 1980s. It is currently approved for clinical usage in Russia, but not anywhere else.

Research has shown that Semax could have the potential ability to increase dopamine levels in the brain, increase blood flow, and improve memory. Furthermore, a 2007 animal study showed that Semax might have the potential ability to treat depression by enhancing the activity of dopamine and serotonin in the brain.

In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

Pure Rawz sells Semax for laboratory research use only.

CAS Number 4037-01-8
Molar Mass 813.93 g/mol
Chemical Formula C37H51N9O10S
IUPAC Name (2S)-1-[2-{[(2S)-1-[(2S)-2-{[2-{[(2S)-2-{[(2S)-2-amino-4-methylsulfanylbutanoyl]amino}-4-carboxybutanoyl]amino}-3-(1H-imidazol-5-yl)propanoyl]amino}-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino}acetyl]pyrrolidine-2-carboxylic acid



What Is Semax?

Semax is a synthetic analog of the adrenocorticotropic hormone 4-10 fragment (ACTH). This synthetic neuropeptide was initially developed in Russia in the 1980s to potentially prevent and treat circulatory disorders and acute cerebral hypoxia (caused by traumatic brain injury). [R][R]

While Semax is yet to be approved by the FDA, multiple studies have highlighted its potential. For example, Semax has been shown potential in improving memory, boosting mental clarity, and increasing dopamine levels in the brain. It might also possess neuroprotective properties. [R]

For instance, in a clinical trial involving 100 patients, Semax’s addition to conventional therapy expedited the restoration of damaged brain functions. In another trial, Semax showed promising potential to reduce overall brain damage and the risk of future strokes in patients with reduced brain blood flow. [R][R]

Pure Rawz doesn’t sell Semax for human consumption.

Semax vs N-Acetyl Semax

Semax and N-Acetyl Semax are both synthetic peptide compounds that have been studied for their potential cognitive-enhancing and neuroprotective effects.

Semax is a synthetic peptide derived from a naturally occurring peptide called adrenocorticotropic hormone (ACTH). It consists of a short sequence of amino acids.

N-Acetyl Semax is an acetylated version of Semax, where an acetyl group is added to the peptide molecule. This modification can affect its stability and potential effects.

N-Acetyl Semax is often believed to have a longer half-life and better stability than Semax, which could affect its duration of action and potential benefits in research subjects.

How does Semax Work?

Given the fact that it hasn’t been extensively studied outside Russia, the potential mechanisms of action of Semax isn’t well understood. However, some early research has identified a few possible routes of action, including:

Increases Brain’s BDNF Levels

Brain-derived neurotrophic factor (BDNF) is a protein produced in the central nervous system. It potentially helps neurons survive by aiding them in their growth, mutation, and development. Aside from that, BDNF may play a crucial role in synaptic plasticity, responsible for learning and memory. [R]

Evidence from multiple animal studies suggests that Semax can potentially stimulate BDNF synthesis. In one study, nasal application of Semax had the potential to increase BDNF levels, both in rat hippocampus and basal forebrain. In another study, Semax treatment produced a potential 8-fold increase in BDNF levels. [R][R]

Reduces Breakdown of Enkephalins

Enkephalins are naturally occurring peptides with potent pain-killing effects. They are primarily produced in the brain and have been implicated in blood pressure regulation, memory processes, neuroprotection, wound repair, respiratory control, and various other functions throughout the body. [R]

A cell-based study has shown that Semax peptide may inhibit enkephalin-degrading enzymes in the human serum. The inhibitory effects of this neuropeptide and Selank (another synthetic peptide) were found to be potentially more potent than other inhibitors of encephalin-degrading enzymes. [R]

Semax Research

Multiple clinical trials have been conducted on Semax. This synthetic peptide has also attracted various animal and cell-based studies. Unfortunately, almost all these studies have been conducted inside Russia. More research is thus needed to fully explore Semax’s potential benefits and side effects.

Semax and Dopamine

Evidence from an animal study suggests that Semax may activate dopaminergic brain systems in rodents. This effect was mediated by D-Amphetamine. Furthermore, the potential increase in dopamine levels was above 20-fold compared with the basal values. [R]

A 2004 study by the same researchers corroborated the findings from the abovementioned study. This study has shown that intraperitoneal administration of 0.15 or 0.6mg/kg of Semax showed the potential to raise the intracellular level of dopamine in the striatum region of rat brains. [R]

Semax and ADHD

A 2007 paper proposed that Semax may have good therapeutic potential in attention-deficit hyperactivity disorder (ADHD). It drew on several lines of evidence to make this proposal. [R]

First, the paper highlighted how Semax potentially stimulated the processes required for memory and learning formation in adults. It then highlighted various studies showing the potential effects of Semax on BDNF release and how this neuropeptide has modulated brain development in animal studies.

Finally, multiple animal studies were quoted showing how Semax, when used alongside one of the most commonly used agents in the treatment of ADHD, potentially increased the agent’s effects on dopamine levels. Thus highlighting how Semax may improve the therapeutic effects of psychostimulants in AHD.

Semax and Memory

A 1997 Russian study demonstrated that Semax could have the ability to significantly improve memory and attention in healthy men under extreme conditions. The study also noted that Semax is capable of potentially stimulating operative memory and attention in experimental animals and human beings. [R]

Furthermore, it was shown that the potential improvements in memory and attention remained over a prolonged period (20-24h after intranasal administration in 0.015-0.050mg/kg doses). More research is needed to fully understand and verify the potential effects of this peptide on memory.

In another rat study, Semax prevented the learning and memory inhibition caused by heavy metals. The inhibition-countering effect of Semax was the same or at least a considerable degree as ascorbic acid, confirming that this peptide may hold antioxidant pharmacological properties. [R]

Semax and Brain Health

A study conducted on rat brain focal ischemia showed that Semax’s neuroprotective effects stem from its ability to affect the expression of genes related to the immune and vascular systems.

In a clinical trial involving 100 patients recovering from an ischemic stroke, the addition of Semax to intensive forms of conventional therapy accelerated the restoration of damaged brain functions, especially motor disorders. The treatment lasted only 5 and 10 days. [R]

In another clinical trial, Semax potentially reduced overall brain damage in people with reduced blood-brain flow. This synthetic peptide also probably reduced the risk of future strokes. Furthermore, results from the trial show that Semax was well-tolerated by the study’s participants. [R]

In a small-scale study, the effects of Semax on optic nerve disease were assessed. Results show that adding Semax with other treatments potentially improved the recovery rate. The combination also potentially reduced the disease’s intensity and improved the patient’s visual functions. [R]

Semax and Heart Health

An animal study was carried out to investigate how the peptide Semax affects the heart rate of rats after myocardial infarction (MI). Results showed that Semax prevented hypertrophy (excessive growth) of the heart caused by hypertension (high blood pressure). [R]

Another rat study established that Semax moderates the hyperactivity of the sympathetic nervous system resulting from MI. If left unchecked, the hyperactivity of the sympathetic nervous system might promote heart failure during the post-infarction (post-heart attack) period. [R]

Semax and Stress

Semax has been shown to potentially counteract some of the effects of stress in animals. This synthetic peptide has demonstrated its potential ability to alleviate stress-induced proliferation of macrophages, types of white blood cells that can become hyper-responsive following exposure to toxicants. [R]

Evidence from another rat study suggests that Semax administration (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress. Yet another study showed that chronic Semax administration has an anxiolytic effect under normal conditions. [R][R]

Semax and Depression

A single application of Semax led to a maximum 1.4-fold increase in BDNF levels in the rat hippocampus. It also stimulated a 1.6-fold increase of tyrosine kinase B receptor (TrkB. These findings are intriguing in finding a potential therapeutic treatment for depression. [R]

That is because a number of studies have demonstrated that reduced BDNF is directly involved in the pathophysiology of depression. Plus, the activation of TrkB signaling is an important trigger for the behavioral effects that are typically observed by antidepressants. [R][R]

Semax and Cognitive Functions

Semax-treated animals showed a distinct increase in the number of conditioned avoidance reactions, convincing the researchers conducting the study to suggest that this peptide affects cognitive brain function. In another study, Semax potentially attenuated cognitive impairment caused by acute stress. [R][R]

Where to Buy Semax?

Pure Rawz is the best place to buy Semax online.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

Semax Summary

Multiple human studies have shown that Semax has the potential to increase dopamine levels in the brain, boost memory and learning, and protect the brain. This research chemical has also been shown to boost heart health in animal studies. Pure Rawz sells Semax and other research chemicals strictly for testing and laboratory experimentation only.



This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

23 reviews for Semax

  1. I Ezra

    I am tried a lot of different anxiety medication and this has helped the most by far

  2. Thomas Johnson

    I am crazy about the results I am getting from Semax.

  3. Johnny C

    Top customer service. Quality products. Keep up the awesome work RAWZ!

  4. Anonymous

    This was more like an “I got this” kind of sensation. No side effects.

  5. Tim Velasquez

    Awesome result. Since using this product I am more attentive and focused.

  6. Anonymous

    Great product. One bottle was all that was required to get going.

  7. Martin Murphy

    I am overall very happy with this product and will definitely buy it again.

  8. Rasheed

    Semax gives a pleasant boost to your day.

  9. Franklin Vet

    I have successfully received my package. Thank you for all your help!

  10. Leo Z

    The shipping was much better this time around. I got my order within a week. Thanks!

  11. Anonymous

    This helped a lot for my ADHD, better than conventional medications.

  12. Anderson

    This made me feel like a brand new person. Highly recommended!

  13. Kevin Lee

    This brand of SEMAX definitely improves my memory and mood.

  14. Anonymous

    Superb! Really helpful and effective.

  15. Samuel Gray

    This definitely helped with my depression and memory.

  16. Marion R.

    Wow, absolutely awesome results. I feel positive and full of life!

  17. Ryder

    Thanks, again will be ordering again soon.

  18. L. Rodgers

    I am very happy to say how much this has boosted my motivation and alertness.

  19. Ivan Schiller

    excellent stuff, no problems. It has worked brilliantly and significantly improved my quality of life.

  20. Mel Kilback

    No physical or neurologic effect noted, after taking it for a week. No ill effects noted, either. Worth it to buy. No side effects. I wish I stocked up personally.

  21. Kevin Rodriguez

    It certainly attenuates brain fog, which I have been living with for the past 10 years due to chronic fatigue syndrome.

  22. Matthew M. (verified owner)

    This is the most potent Semax I’ve used by far.

  23. Franck (verified owner)

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