Sermorelin – Product Information
Sermorelin is a synthetic growth hormone (GH) secretagogue. It stimulates the natural production of human growth hormone (HGH) in the pituitary gland. Sermorelin is clinically used as a potential diagnoses and treatment tool for growth hormone deficiency in children. [R]
Sermorelin was initially developed in the US in the early 1980s. At the time, it helped researchers detect potential growth hormone deficiency within the pituitary gland. In 1997, the FDA approved Sermorelin to detect and treat GH deficiency in children.
In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.
What is Sermorelin?
Sermorelin is a growth hormone-releasing hormone (GHRH) analog. It is derived from the first 29 amino acids of the GHRH protein. Sermorelin weighs in at 3357.9 g/mol and has a half-life of 11-12 minutes, extremely short when compared to that of other peptides. [R]
Research has highlighted the following potential effects of Sermorelin:
- Potentially increases growth rate in GH-deficient children [R]
- Potentially increases GH and IGF-1 levels in men with reduced IGF-1 levels [R]
- Potentially increases lean body mass, insulin sensitivity, general well-being, and libido in men [R]
- Potentially increases testosterone secretion in GH-deficient rats [R]
PureRawz sells Sermorelin for laboratory and research use only.
How Does Sermorelin Work?
Sermorelin stimulates GHRH via the hypothalamic-pituitary-somatotropic axis. Its working mechanism distinguishes Sermorelin from other growth hormone secretagogues, such as Ipamorelin, which work via the ghrelin/growth hormone secretagogue receptor (GHS-R) pathway. [R]
GHRH is produced in the hypothalamus. Its principal function is the potential ability to increase growth hormone secretion. GH, in turn, may increase bone density and muscle mass, reduce body fat, and enhance growth in adolescents and children. It also maintains normal body structure and metabolism. [R]
Sermorelin vs GRF 1-29
Both Sermorelin and GRF 1-29 (CJC-1295) work by binding to receptors in the pituitary gland and stimulating the release of growth hormone. However, due to its longer half-life, GRF 1-29 (CJC-1295) provides a sustained and prolonged increase in GH levels compared to Sermorelin.
Sermorelin acetate is one of the few peptides that have attracted multiple clinical trials. Its effects have also been investigated in numerous animal studies. These human and animal studies have shown that Sermorelin holds immense potential as a GH secretagogue.
Sermorelin and GH
In a study involving 9 young male subjects and 10 elderly male subjects, high-dose Sermorelin treatment elevated mean 24-hour growth hormone among the elderly. Furthermore, at higher doses, there was no significant difference in parameters between both age groups. [R]
Another study demonstrated similar results, though Sermorelin also increased prolactin, follicle-stimulating hormone, and luteinizing hormone. These findings revealed that Sermorelin could successfully secrete growth hormone, similar to those observed with endogenous GHRH. [R]
Sermorelin and IGF-1
A study involving 9 young male subjects 22 to 33 years old and 10 elderly subjects 60 to 78 years old showed that twice daily Sermorelin treatment could potentially increase IGF-1 levels. Furthermore, the IGF-1 levels in elderly men remained above baseline levels even two weeks after stopping Sermorelin. [R]
However, in another clinical trial, once nightly administration of Sermorelin in healthy elderly men didn’t significantly increase IGF-1 levels. This suggests that the timing and frequency of Sermorelin treatment significantly affect IGF-1 levels. [R]
Sermorelin and Height
Results obtained from a clinical trial show that a once-daily subcutaneous administration of Sermorelin accelerates growth in GH-deficient children. No adverse changes in general biochemical or hormone analyses were noted, and overall, this GHRH was well-tolerated. [R]
Another study found that twice-daily administration of Sermorelin promoted linear growth in short children who were not GH-insufficient. The improved height velocity was sustained throughout the 12 months of treatment. There was also a change in glucose homeostasis during the study. [R]
Sermorelin and Lean Body Mass
In a clinical trial, Sermorelin treatment showed the potential to increase lean body mass in male subjects. 19 participants from both genders participated in the study, but this potential increase was observed in male subjects only, who experienced a 1-kg gain in lean body mass after 4 months of Sermorelin treatment. [R]
The only adverse side effect was transient hyperlipidemia, which resolved by the end of the study. No other adverse effects were encountered.
Sermorelin and Libido
In the abovementioned trial, 4 months of Sermorelin treatment showed the potential to increase men’s libido (sexual drive), similar to PT-141. The potentially improved libido was unrelated to changes in serum androgens. Serum testosterone, DHT, and sex hormone-binding globulin were unaltered.
These observations suggest that potential Sermorelin-induced anabolic effects favor men more than women, for reasons that aren’t clear yet. Further studies are needed to define the gender differences observed in response to the administration of this GHRH analog.
Sermorelin and Testosterone
A study examining GH-deficient rats showed that Sermorelin therapy increases testosterone secretion. In addition, this peptide increased testicular luteinizing hormone (LH) receptors. [R]
However, in the abovementioned clinical trial, Sermorelin had no effect on the testosterone levels of the participants. This indicates that more research is needed to understand and substantiate the effects of this research chemical on testosterone.
Sermorelin and Heart Health
A 2016 study involving pigs demonstrated that Sermorelin administration effectively reduces the remodeling that follows a heart attack. This synthetic HGH analog also reduced cell death in cardiomyocytes. Plus, it increased the growth of blood cells in the damaged tissue. [R]
Furthermore, treatment with GHRH agonists appears to reduce the inflammatory responses post-myocardial infarction and may consequently improve mechanisms of healing and cardiac remodeling, per the results from a cell-based study. [R]
Sermorelin and Muscle Endurance
In a clinical study involving 11 male subjects aged 64 to 76 years, the effects of once-nightly administration of Sermorelin were noted. This research chemical’s administration led to a potentially significant improvement in the abdominal crunch, a test of muscle endurance. [R]
Where to Buy Sermorelin Online
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