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Sermorelin – Product Information

Sermorelin is a synthetic growth hormone (GH) secretagogue. It stimulates the natural production of human growth hormone (HGH) in the pituitary gland. Sermorelin is clinically used as a potential diagnoses and treatment tool for growth hormone deficiency in children. [R]

Sermorelin was initially developed in the US in the early 1980s. At the time, it helped researchers detect potential growth hormone deficiency within the pituitary gland. In 1997, the FDA approved Sermorelin to detect and treat GH deficiency in children.

In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

CAS Number 86168-78-7
Molar Mass 3357.93 g/mol
Chemical Formula C149H246N44O42S
IUPAC Name L-Tyrosyl-L-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide

What is Sermorelin?

Sermorelin is a growth hormone-releasing hormone (GHRH) analog. It is derived from the first 29 amino acids of the GHRH protein. Sermorelin weighs in at 3357.9 g/mol and has a half-life of 11-12 minutes, extremely short when compared to that of other peptides. [R]

Research has highlighted the following potential effects of Sermorelin:

  • Potentially increases growth rate in GH-deficient children [R]
  • Potentially increases GH and IGF-1 levels in men with reduced IGF-1 levels [R]
  • Potentially increases lean body mass, insulin sensitivity, general well-being, and libido in men [R]
  • Potentially increases testosterone secretion in GH-deficient rats [R]

PureRawz sells Sermorelin for laboratory and research use only.

How Does Sermorelin Work?

Sermorelin stimulates GHRH via the hypothalamic-pituitary-somatotropic axis. Its working mechanism distinguishes Sermorelin from other growth hormone secretagogues, such as Ipamorelin, which work via the ghrelin/growth hormone secretagogue receptor (GHS-R) pathway. [R]

GHRH is produced in the hypothalamus. Its principal function is the potential ability to increase growth hormone secretion. GH, in turn, may increase bone density and muscle mass, reduce body fat, and enhance growth in adolescents and children. It also maintains normal body structure and metabolism. [R]

Sermorelin vs GRF 1-29

Both Sermorelin and GRF 1-29 (CJC-1295) work by binding to receptors in the pituitary gland and stimulating the release of growth hormone. However, due to its longer half-life, GRF 1-29 (CJC-1295) provides a sustained and prolonged increase in GH levels compared to Sermorelin.

Sermorelin Research

Sermorelin acetate is one of the few peptides that have attracted multiple clinical trials. Its effects have also been investigated in numerous animal studies. These human and animal studies have shown that Sermorelin holds immense potential as a GH secretagogue.

Sermorelin and GH

In a study involving 9 young male subjects and 10 elderly male subjects, high-dose Sermorelin treatment elevated mean 24-hour growth hormone among the elderly. Furthermore, at higher doses, there was no significant difference in parameters between both age groups. [R]

Another study demonstrated similar results, though Sermorelin also increased prolactin, follicle-stimulating hormone, and luteinizing hormone. These findings revealed that Sermorelin could successfully secrete growth hormone, similar to those observed with endogenous GHRH. [R]

Sermorelin and IGF-1

A study involving 9 young male subjects 22 to 33 years old and 10 elderly subjects 60 to 78 years old showed that twice daily Sermorelin treatment could potentially increase IGF-1 levels. Furthermore, the IGF-1 levels in elderly men remained above baseline levels even two weeks after stopping Sermorelin. [R]

However, in another clinical trial, once nightly administration of Sermorelin in healthy elderly men didn’t significantly increase IGF-1 levels. This suggests that the timing and frequency of Sermorelin treatment significantly affect IGF-1 levels. [R]

Sermorelin and Height

Results obtained from a clinical trial show that a once-daily subcutaneous administration of Sermorelin accelerates growth in GH-deficient children. No adverse changes in general biochemical or hormone analyses were noted, and overall, this GHRH was well-tolerated. [R]

Another study found that twice-daily administration of Sermorelin promoted linear growth in short children who were not GH-insufficient. The improved height velocity was sustained throughout the 12 months of treatment. There was also a change in glucose homeostasis during the study. [R]

Sermorelin and Lean Body Mass

In a clinical trial, Sermorelin treatment showed the potential to increase lean body mass in male subjects. 19 participants from both genders participated in the study, but this potential increase was observed in male subjects only, who experienced a 1-kg gain in lean body mass after 4 months of Sermorelin treatment. [R]

The only adverse side effect was transient hyperlipidemia, which resolved by the end of the study. No other adverse effects were encountered.

Sermorelin and Libido

In the abovementioned trial, 4 months of Sermorelin treatment showed the potential to increase men’s libido (sexual drive), similar to PT-141. The potentially improved libido was unrelated to changes in serum androgens. Serum testosterone, DHT, and sex hormone-binding globulin were unaltered.

These observations suggest that potential Sermorelin-induced anabolic effects favor men more than women, for reasons that aren’t clear yet. Further studies are needed to define the gender differences observed in response to the administration of this GHRH analog.

Sermorelin and Testosterone

A study examining GH-deficient rats showed that Sermorelin therapy increases testosterone secretion. In addition, this peptide increased testicular luteinizing hormone (LH) receptors. [R]

However, in the abovementioned clinical trial, Sermorelin had no effect on the testosterone levels of the participants. This indicates that more research is needed to understand and substantiate the effects of this research chemical on testosterone.

Sermorelin and Heart Health

A 2016 study involving pigs demonstrated that Sermorelin administration effectively reduces the remodeling that follows a heart attack. This synthetic HGH analog also reduced cell death in cardiomyocytes. Plus, it increased the growth of blood cells in the damaged tissue. [R]

Furthermore, treatment with GHRH agonists appears to reduce the inflammatory responses post-myocardial infarction and may consequently improve mechanisms of healing and cardiac remodeling, per the results from a cell-based study. [R]

Sermorelin and Muscle Endurance

In a clinical study involving 11 male subjects aged 64 to 76 years, the effects of once-nightly administration of Sermorelin were noted. This research chemical’s administration led to a potentially significant improvement in the abdominal crunch, a test of muscle endurance. [R]

Where to Buy Sermorelin Online

PureRawz is the best place to buy Sermorelin online.

In order to be the best research chemicals supplier, we provide reference materials with every product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority – if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.


COA Sermorelin lot PRWZ 092 2023 08 23 PR2 1

15 reviews for Sermorelin

  1. Riley Waterman

    Highly responsive customer service. I just got my package today and cannot wait to start!

  2. William Howell

    I have to say you guys have to be the best in the game. I come back every time for more.

  3. Pablo

    Great quality, and works really well! Go Purerawz!

  4. Jayden L

    I got my package within a week of ordering it and I am really looking forward to starting.

  5. Stevenson Charles

    This cycle has kicked in nicely on my rat. I can slightly see the difference and the energy levels are up only two weeks in. Definitely value for my money.

  6. Cameron Ellis

    I have arthritis and this product helped me recover faster, as well as improving the condition.

  7. Danny

    This really helped me improve my performance and gives me more energy to get through more strenuous workouts.

  8. Ernest Torres

    If you want something that will genuinely help you with growth, buy this.

  9. Grant S

    It truly made a difference.

  10. Walter Morris

    After taking this for about a month I would certainly recommend it.

  11. Aaron Valentine

    Awesome size gains so far, very happy with what I received.

  12. G. Champlin

    The place to go for all your supplement needs!!!!

  13. Anonymous

    Looking younger because of this amazing peptide. I also noticed that I am much more stronger and energetic the whole day.

  14. Jerry Edwards

    It’s a great supplement; it gives me the boost I need to power through my daily workout. I highly recommend it!

  15. virgildominguez

    This Sermorelin is incredible!

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