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Synephrine – Product Information

Bitter orange extract, derived from the Citrus aurantium tree, contains an active ingredient known as synephrine. This compound is recognized for its potential role in fat-burning and weight loss. It’s important to note that synephrine shares similarities with ephedrine, a substance that raised concerns due to its impact on the heart. In 2004, the FDA banned ephedrine due to these cardiac-related concerns.

In response to this ban, the weight loss and bodybuilding industry turned to bitter orange extract, often combined with caffeine, as an alternative. Bitter orange contains various chemicals that can affect the nervous system, potentially influencing factors related to weight loss. However, it’s essential to exercise caution when considering products containing bitter orange extract, as these chemicals may pose risks to the heart, especially in healthy adults.

Disclaimer: This product information is provided for informational purposes only and does not constitute a recommendation or endorsement of any specific product. Consult with a healthcare professional before undertaking any weight loss or dietary research.

CAS Number 94-07-5
Molar Mass 167,21 g/mol
Chemical Formula C9H13NO2
IUPAC Name 4-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol

What is Synephrine?

Synephrine (aka synephrine HCl), found in Bitter Orange Extract (Citrus aurantium), is a naturally occurring compound known for its potential in fat burning and appetite reduction. Bitter orange, originating from Southeast Asia but now widely cultivated globally, contains a range of beneficial substances, including vitamins C and K.

Synephrine HCL, found within the bitter orange extract, exhibits natural stimulant properties along with a thermogenic effect. This combination of attributes contributes to its notable benefits. It has the ability to stimulate the metabolism, aiding in the burning of excess fat, and has been associated with reducing appetite, particularly curbing cravings for sweets, making it valuable for those aiming to control their dietary intake in subjects. Moreover, it may support various metabolic processes, potentially promoting overall metabolic health and enhancing the functioning of the urinary system.

Possible Applications of Synephrine

Fat Burning

Synephrine HCL has gained attention for its potential to boost fat burning by increasing metabolic rate. Laboratory studies, such as one published in the International Journal of Medical Sciences in 2017, have demonstrated that synephrine can enhance energy expenditure and fat oxidation compared to a placebo. This effect can be particularly beneficial for participants seeking to shed excess body fat. [R]

Appetite Suppression

Clinical research suggests that Synephrine HCL may act as an appetite suppressant. The study published in 2013 found that test subjects who consumed synephrine alongside caffeine reported reduced feelings of hunger and reduced desire to eat. This appetite control can aid in maintaining a calorie deficit necessary for weight loss. [R]

Energy Boost

Synephrine HCL’s stimulant properties may lead to increased alertness and energy levels. A study in “Current Therapeutic Research” in 2016 discovered that synephrine supplementation possibly enhanced physical performance and perceived energy levels during exercise. This boost in energy can be advantageous for those engaging in workouts or seeking improved mental focus throughout the day. [R]

Metabolic Support

Synephrine HCL has been investigated for its potential to support metabolic processes in the body. Research published in 2011 suggested that synephrine may elevate resting metabolic rate, contributing to an increase in calorie expenditure even at rest. This can be especially beneficial for participants looking to maintain a healthy weight. [R]

Weight Loss Aid

When considering its combined benefits, Synephrine HCL has been studied as a potential weight loss aid. A review published in the American Journal of Clinical Nutrition in 2010 discussed the role of synephrine in enhancing weight loss when used alongside other ingredients. This synergy can contribute to more significant and sustainable weight management. [R]

How Does Synephrine HCl Work?

Synephrine HCL, commonly found in bitter orange extract, exerts its effects through several key mechanisms of action in the body. Primarily, it operates by stimulating adrenergic receptors, particularly beta-3 adrenergic receptors found in fat cells. This stimulation initiates a cascade of physiological responses. One of the most prominent effects is the enhancement of lipolysis, where stored fat is broken down into free fatty acids, which can be utilized as an energy source. Simultaneously, the activation of adrenergic receptors elevates the basal metabolic rate (BMR), increasing the number of calories burned, even during periods of rest.

This augmentation of BMR, coupled with synephrine’s promotion of thermogenesis (the production of heat), contributes to calorie and fat burning. While its impact on appetite regulation is less understood, some studies suggest that synephrine HCL may reduce feelings of hunger and cravings, assisting with calorie control. Additionally, synephrine HCL acts as a sympathomimetic compound, providing an energy boost and heightened alertness.

Frequently Asked Questions

What is Synephrine HCL, and where can I find it?

Synephrine HCL is a compound often derived from bitter orange extract. You may inquire with a reputable compound company, check the link to their website when ordering, and in addition, visit a health food store to find products containing Synephrine HCL.

Is Synephrine HCL potentially helpful for weight loss?

Synephrine HCL has been studied for its potential benefits in weight management, including fat-burning and appetite control among other things.

Where Can You Buy Synephrine HCl Online?

PureRawz is the best place to buy the highest-quality Synephrine HCl online. Our site contains Synephrine reviews from our customers.

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This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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