Tesamorelin

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Description

Tesamorelin – Product Information

Tesamorelin is a growth hormone-releasing hormone (GHRH) analog that has been shown to increase growth hormone and IGF-1 levels.

According to one clinical study, 10.9 percent of subjects who were given Tesamorelin experienced reductions in deep belly fat. The study lasted six months in total. Overall, visceral fat levels decreased by eighteen percent.

In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

Tesamorelin Peptide
CAS Number 901758-09-6
Molar Mass 5135.86 g·mol−1
Chemical Formula C221H366N72O67S
IUPAC Name Unk-Tyr-Ala-Asp-Ala-xiIle-Phe-xiThr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-xiIle-Met-Ser-Arg-Gln-Gln-Gly-Gln-Ser-Asn-Gln-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

 

What is Tesamorelin?

Tesamorelin is a synthetic polypeptide analog of growth hormone-releasing hormone. This growth hormone-releasing factor (GHRF) is similar to the hormone released from the hypothalamus gland in the brain. It has a molecular weight of 5146 kg/mole. [R]

Tesamorelin was developed by a Montreal (Canada) based company called Theratechnologies to treat lipodystrophy, a common condition in HIV-infected patients.

In November 2010, the FDA approved Tesamorelin as a treatment for HIV-associated lipodystrophy. [R]

In two phase 3 clinical trials, Tesamorelin was proven to significantly decrease waist circumference and visceral adipose tissue (VAT) following 26 weeks of treatment. Both studies had 26-week extension phases that confirmed the maintenance of VAT improvements. [R]

How does Tesamorelin Work?

Tesamorelin potentially activates GHRH receptors in the pituitary gland. This may lead to the synthesis and release of growth hormone, which, in turn, acts on multiple cells of the body to stimulate the production of insulin-like growth factor 1 (IGF-1).

IGF-1 mediates many of the effects of the growth hormone, which in the liver include growth, inhibition of programmed cell death, glucose update, and lipolysis. Serum IGF-1 levels tend to be low in patients with obesity, diabetes, and lipodystrophy. [R]

PureRawz sells Tesamorelin for laboratory and research use only.

Tesamorelin Research

Available medical research suggests that Tesamorelin is effective in reducing excess fat in the stomach area in people with HIV-associated lipodystrophy. Furthermore, in a 2012 study, the Tesamorelin peptide had positive effects on cognition in research subjects. [R]

A clinical trial is ongoing to assess the efficacy of Tesamorelin as a therapy for peripheral nerve injury. The investigators hypothesize that Tesamorelin treatment will allow for faster and greater recovery of motor and sensory function after surgical repair of peripheral nerves. [R]

Tesamorelin and Lipodystrophy

Lipodystrophy is a condition that causes a person to lose fat from some parts of the body while gaining it in others. It occurs in HIV patients who are being treated with antiretroviral therapy (ART). It targets the face, arms, legs, buttocks, and truncal areas. [R]

A literature review was conducted to evaluate the efficacy and safety of Tesamorelin for the treatment of lipodystrophy associated with HIV infection. All articles published in English, and identified from data sources were evaluated, and all pertinent information was included.

The review found that Tesamorelin is effective in improving visceral adiposity and body image in patients with HIV-associated lipodystrophy over 26-52 weeks of treatment. Tesamorelin thus provides a useful treatment option for the management of HIV-associated lipodystrophy. [R]

Tesamorelin and Cardiovascular Disease

Clinical research suggests that heart failure and abnormal heart rhythms may be more likely in people living with HIV. Moreover, an analysis of a large healthcare database showed that HIV-infected individuals are at an increased risk of developing cardiovascular disease. [R] [R]

In a randomized trial involving HIV subjects, the levels of triglycerides decreased by 50mg per deciliter in the Tesamorelin group, compared with 9 mg per deciliter in the placebo group. Levels of total and HDL cholesterol also improved significantly in the Tesamorelin group. [R]

Tesamorelin and Body Composition

Tesamorelin selectively reduced visceral adipose tissue (VAT) in a randomized, double-blind, placebo-controlled study. Other body composition parameters, including waist circumference, total fat, and lean body mass improved in the Tesamorelin vs. placebo groups.

There were no serious adverse events during the study. No significant difference in adverse events between Tesamorelin and placebo groups was observed in the rats. [R]

Tesamorelin and Cognition

According to a study published in the Archives of Neurology, administering Tesamorelin to patients with mild cognitive impairment or healthy older adults has positive effects on cognition. The researchers recruited 152 adults for the study, of whom 137 completed it.

Tesamorelin improved executive function and, to a lesser degree, short-term verbal memory. Cognitive function improved in healthy adults, and the expected functional decline of those with mild cognitive impairment was attenuated. [R]

PureRawz sells Tesamorelin for testing and laboratory experimentation and not for human consumption.

Tesamorelin and Memory

A randomized, double-blind, placebo-controlled trial demonstrated that Tesamorelin administration has a favorable effect on verbal memory for subjects with mild cognitive impairment (MCI), who are at a high risk of progression to Alzheimer’s dementia. [R]

Tesamorelin FAQs

Is Tesamorelin FDA approved?

The FDA has approved Tesamorelin for the treatment of lipodystrophy in subjects with HIV infection.

What is the Half-Life of Tesamorelin?

Tesamorelin has an estimated half-life of 8-10 minutes.

Does Tesamorelin have the potential to increase IGF-1?

Yes. Research has shown that Tesamorelin may have the ability to increase IGF-1 production. [R]

Does Tesamorelin have the potential to reduce Abdominal Fat?

In a 2014 clinical trial, Tesamorelin administered for 6 months was associated with reductions in visceral fat and additionally with modest reductions in liver fat. [R]

Where to Buy Tesamorelin Online

PureRawz is the best place to buy Tesamorelin online.

In order to be the best research peptides supplier, we provide reference materials with every product we sell. All of our research chemicals come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.

Click on the ‘Reviews’ tab to check out what existing customers have to say in their own reviews about our products.

Summary

Tesamorelin, a GHRH analog, has been approved by the FDA for the treatment of lipodystrophy in HIV-positive patients. In multiple clinical trials, this peptide has demonstrated the potential ability to enhance cognition, improve the body’s metabolic parameters and reduce the risk of cardiovascular disease.

 

Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority – if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.
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15 reviews for Tesamorelin

  1. Brad

    My experience was amazing. The product was delivered on time – only had trouble tracking my order.

  2. Maxwell

    Thank you PureRawz, excellent customer service and fast shipping. I just received it today and can’t wait to try it.

  3. Thomas Levy

    I lost weight without knowing it. This product works!

  4. Anonymous

    Getting rid of belly fat and love handles in a very short time while building lean muscle, amazing product.

  5. Rylee

    I recommend this! Belly fat is shrinking!

  6. Anthony

    Helped me get pretty lean.

  7. Edward Torres

    My weight loss seemed to plateau no matter what I did. But with this, I’m finally losing fat again.

  8. Walker B

    Happy customer. Will buy again soon.

  9. Albert Lewis

    Works great. I was skeptical at first, but after 1 month of dieting and exercise, it’s visible in my belly!

  10. Cesar Foley

    delivered impressive results.
    highly recommended!!

  11. Jamil Howell

    Losing more and more fat by the day!

  12. Judith Hudson (verified owner)

    I love the quality of your products! The packaging and attention to detail is outstanding! Thank you for the great products you offer.

  13. Judith Hudson (verified owner)

    Great quality product! I am so impressed with the product packaging and sterile handling. Thank you!

  14. Christopher Battig (verified owner)

  15. Tori Kay (verified owner)

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