Uridine Monophosphate Disodium (Powder) 50g – Product Details

Uridine Monophosphate Disodium is a nucleotide base that acts as a monomer in RNA. Uridine Monophosphate Disodium is also known by the chemical formula C9H13N2O9P or as 5’-uridylic acid or uridine 5 monophosphate. It is a chemical compound derived from phosphoric acid and the nucleoside uridine, and is potentially used in the body to increase the formation of cellular membranes. Uridine Monophosphate is being researched for several potential benefits relating to cognitive and physical health.

There are several Uridine Monophosphate uses such as signaling the creation of neurotransmitter synapses and potentially helping promote DNA repair, and the growth of cells.

Uridine Monophosphate Disodium
CAS Number	9858-97-9
Molar Mass	324,1813g/mol-1
Chemical Formula	C9H13N2O9P
IUPAC Name	[(2R,3S,4R,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

What is Uridine Monophosphate Disodium Salt?

Uridine Monophosphate disodium, also known as Uridine 5′-monophosphate disodium salt, is a nucleotide that is a major component of ribonucleic acid. It has been demonstrated to improve cognitive performance in animals and is present as a dietary supplement, as well as naturally occurring foods rich in RNA.

How Does Uridine Monophosphate Disodium Salt Work?

Uridine is thought to enhance phosphatidylcholine levels in the brain, which is thought to aid synaptic processes. The dendritic membranes’ essential component is phosphatidylcholine. The Kennedy cycle, commonly known as the CDP-choline pathway, uses uridine as a substrate to produce phosphatidylcholine (PC). In this route, phosphatidylethanolamine is also produced. This is significant because phosphatidylethanolamine, a phospholipid, is essential for neurotransmission and helps to construct the membranes of brain cells.

According to research, uridine has the potential to enhance phosphatidylcholine levels in the brain, which may help synaptic processes. A vital element of dendritic membranes and an essential component for their operation is phosphatidylcholine. The Kennedy cycle, also known as the CDP-choline pathway, is used to synthesize phosphatidylcholine (PC), and uridine serves as a substrate in this process. This pathway also allows for the synthesis of phosphatidylethanolamine. This is significant because phosphatidylethanolamine, a phospholipid, is essential for the development of brain cell membranes and for neurotransmission.

Choline kinase catalyzes the conversion of choline into phosphocholine in the Kennedy cycle, using an ATP molecule in the process. This enables the conversion of more cellular choline into phosphocholine. When fed a diet rich in uridine monophosphate, choline, and docosahexaenoic acid, mice studied using uridine appeared to have better cognitive function (DHA). [R]

In other research, participants who took a uridine DHA stack—that is, a uridine supplement and a DHA supplement taken simultaneously—showed improved cognition. A phospholipid called phosphatidylcholine is both necessary for synapse function and advantageous for general cellular health and function. Uridine and cytidine are needed to make CDP-choline, which is needed to make phosphatidylcholine. Conveniently, the body can convert uridine to cytidine, simplifying the procedure considerably. [R]

Uridine Monophosphate Disodium Research

Purerawz sells Uridine Monophosphate Disodium for research purposes only. This product is not intended to diagnose, treat, cure or prevent any disease or illness. Please speak to a qualified health physician if you have any suspected medical conditions. However, Uridine Monophosphate has undergone several clinical and animal studies. Below are some of the proposed Uridine Monophosphate benefits:

Uridine Monophosphate on Learning, Memory, and Brain Health

Studies have observed that Uridine Monophosphate may potentially promote learning and memory by increasing acetylcholine production. Acetylcholine is a prominent neurotransmitter. [R]

Results from Uridine rodent studies suggest that Uridine Monophosphate may help promote spatial learning, attention span, and mental clarity. This may be a result of the compound’s impact on certain neurotransmitters associated with mood, motivation, and attention span. [R]

Uridine Monophosphate on Sleep

Uridine Monophosphate may also support restful sleep. Rat studies found that uridine increased slow-wave or deep sleep, particularly in sleep-deprived rats. Preliminary studies show that slow-wave sleep is needed to help the brain’s recovery process from daily activities. Thus, this may be an indirect way that Uridine Monophosphate takes to help promote cognition. [R]

Uridine Monophosphate and Alzheimer’s Disease

Because it helps with synaptic connections, which seem to be weakening in the state of Alzheimer’s, uridine is thought to help with Alzheimer’s disease. [R]

In one study, rats with increased -amyloid synthesis (and hence prone to Alzheimer’s) showed considerable improvements in Alzheimer’s pathology; however, the benefits of uridine were too complicated by the effects of other nutrients to be determined. [R]

Uridine Monophosphate and Bipolar Disorder

An open-label study for 6 weeks of children with bipolar disorder, found that supplementing with uridine monophosphate capsules resulted in significantly fewer depressive symptoms than baseline (from an average score of 65.6 on the CDRS-R to 27.2 with efficacy within a week). [R]

Uridine Monophosphate on Fat Mass

Lipodystrophy is a localized loss of fat mass, and is usually seen alongside HIV therapy using Nucleoside reverse transcriptase inhibitors (NRTIs).

In a multicenter research study, Uridine was well tolerated and had no detrimental effects on the virological response, although it was linked to an increase in limb fat (viewed as an endpoint measure of normalizing lipodystrophy) at 24 weeks, but was absent at 48 weeks. [R]

FAQs

Do Researchers Stack Uridine Monophosphate Disodium Salt?

According to MIT studies, Uridine and the B vitamin Choline interact quite favorably. This has seen researchers stack Uridine Monophosphate Disodium with either Alpha GPC or CDP Choline.

The combination enhances selective attention and spatial awareness while producing more neuron cell membranes. [R]

Where to Buy Uridine Monophosphate Online

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This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

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