What is Aniracetam?

Aniracetam is a member of the nootropic class of compounds, with possible cognition-enhancing effects. It was initially developed in the 1970s by the Swiss pharmaceutical company Hoffman-La Roche and is available by prescription in Europe. However, the US FDA hasn’t approved it. [R]

Aniracetam belongs to the racetam family, a group of compounds that have the same chemical backbone (a pyrrolidone ring). Piracetam, the “original” racetam, is the family’s parent member. Other famous racetam chemical compounds include Oxiracetam and Phenylpiracetam. [R][R]

Unlike many racetams, Aniracetam can penetrate the blood-brain barrier. In studies, this nootropic compound has demonstrated a relatively short half-life of 30 – 40 minutes. It has also been shown that Aniracetam has a half-hour therapeutic window for exerting its potential effects. [R][R][R]

Speaking of effects, Aniracetam has been shown to potentially improve attention, memory, and logical-perceptual ability in mild-to-moderate Alzheimer’s disease patients. The nootropic has also been reported to potentially improve mood and prevent cognitive decline in people with dementia. [R][R]

How does Aniracetam Work?

Aniracetam activates a-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-type glutamate receptors in neuronal cultures. This action reportedly increases the density of receptor binding sites for AMPA and calcium uptake, presumably resulting in the elevation of intracellular calcium. [R]

In addition to this effect, various animal and cell-based studies have shown that Aniracetam:

• Potentially Increases acetylcholine transmission in the brain [R]
• Potentially Reduces dopamine levels in the hypothalamus and striatum regions of the brain [R]
• Potentially Increases serotonin levels in some brain regions (striatum and cortex) and decreases them in others (hypothalamus) [R]

Aniracetam Research

What follows is a summary of the existing clinical and preclinical research on Aniracetam. The information presented in this section is for educational purposes only and doesn’t constitute medical advice. PureRawz sells this Nootropic compound for research use only.

Aniracetam and Dementia

According to a double-blind placebo-controlled trial, Aniracetam treatment may have potentially improved attention, verbal and visuospatial memory, and logical-perceptual ability in patients with mild to moderate Alzheimer’s disease. The potential improvements were at least 20% higher than baseline levels. [R]

Another study of 60 elderly patients with primary or secondary mental deterioration found that Aniracetam treatment (1,500 mg/day for four months) potentially improved cognitive function. No statistically significant changes were observed in the placebo group members. [R]

Yet another study investigated the clinical efficacy of Aniracetam in patients with cognitive impairment. The patients were treated with cholinesterase inhibitors, Aniracetam, or both. The group treated with Aniracetam experienced a potentially improved mood and reduced cognitive decline. [R]

Aniracetam and Depression

A 2016 review of various clinical and preclinical studies noted that Aniracetam and similar compounds showed promise for depression. The study quoted in the review notes that Aniracetam potentially positively affected geriatric depression, a mental health condition affecting older adults. [R][R]

To further investigate its anti-depressive effects, a rat study was conducted. Results from the study show that subcutaneous administration of Aniracetam reduced immobility time in aged rats. This effect points to a decrease in depressive symptoms. [R]

Aniracetam and Sleep

REM sleep is a stage of sleep that plays an essential role in memory, emotional processing, and healthy brain development. Research has shown that the lack of REM sleep could lead to dementia. [R]

According to a study carried out on stroke-prone rats, Aniracetam treatment for 5 days reduced REM sleep during the day and excessive non-REM sleep at night. The authors conducting this review write that Aniracetam could improve REM sleep impairment caused by vascular dementia. [R]

Aniracetam and Anxiety

In three different mouse models of anxiety, Aniracetam exhibited its anti-anxiety effects by increasing social interactions and improving performance in fear stress tests. These results indicate that Aniracetam possesses a wide range of anxiolytic (anti-anxiety) properties. [R]

However, in another mice study, no differences in anxiety were found between the control group and the Aniracetam-treated group. The contradictory effects reported by both studies necessitate further research into the anxiolytic properties of Aniracetam capsules and powder. [R]

Aniracetam and Brain Damage

Fetal alcohol syndrome (FAD) is a plethora of birth defects and developmental disabilities experienced by babies whose mothers drink alcohol during pregnancy. Aniracetam was found to reverse cognitive deficits (memory and learning impairments) in a mice model of FAD. [R]

Cerebral infarction refers to a brain stroke that occurs due to a disrupted blood supply to the brain. An animal study showed that Aniracetam increased bladder capacity in rats with this condition. In the animals studied, cerebral infarction had caused bladder overactivity. [R]

Aniracetam and Memory and Focus

In three rat studies, Aniracetam treatment reversed memory loss and improved behavioral performance. The nootropic compound also improved memory loss caused by sleep deprivation. Aside from that, it increases focus impaired by the administration of apomorphine. [R][R][R]

A fourth animal study found that Aniracetam administration ameliorated impulsive behavior induced by a blockade of AMPA receptors in rats. While these studies highlight the nootropic effects of Aniracetam, clinical research is still needed to verify these effects in humans. [R]

Aniracetam Vs Piracetam

Despite being members of the same family, Aniracetam and Piracetam have their fair share of differences. For example, while Piracetam is water soluble and exhibits poor solubility in lipids, the reverse is true for Aniracetam, which is fat soluble.

Furthermore, while Aniracetam has an extremely short half-life (30 – 40 minutes), the plasma half-life of Piracetam in subjects is about 5 hours following oral or intravenous administration. This means that Piracetam lasts longer than Aniracetam. [R]

Aniracetam Side Effects

According to studies conducted on this racetam, the most common adverse reactions of Aniracetam usage are potentially insomnia, uneasiness, and anxiety. These effects were observed at decreased quantity or dosage. At higher dosages, potential headaches, diarrhea, and vertigo were observed. [R]

Speak to a qualified professional to know more about any associated risks of Aniracetam.

Where to Buy Aniracetam Online?

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Summary

Aniracetam is a nootropic compound belonging to the racetam family. Clinical studies have demonstrated the potential ability to improve cognitive functions (learning, memory, etc.) in people with mild-to-moderate cognitive impairment.

PureRawz sells Aniracetam for laboratory research use only. If you’re uncertain of the appropriate handling methods, please consult a professional.