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PRL-8-53 – Product Information

PRL-8-53 belongs to the cholinergic family of nootropic research compounds. Researchers believe that it has cholinergic properties that would allow increases in acetylcholine activity, which is a neurotransmitter in the brain that plays a critical role in cognition and memory.

Preliminary studies also suggest it may increase dopamine levels in the brain, which are connected to our memory function, fatigue levels, and motivation. Low dopamine levels have been linked to depression, restless legs syndrome, and Parkinson’s disease.

PRL 8-53
CAS Number 51352-88-6
Molar Mass 283.371 g/mol
Chemical Formula C18H21NO2
IUPAC Name Methyl 3-[2-[benzyl(methyl)amino]ethyl]benzoate

What is PRL 8-53?

PRL-8-53 is a research compound derived from benzoic acid. It contains the phenylethylamine (PEA) skeleton within its structure. Benzoic acid is a staple ingredient in fruits, dairy products, and plants and animal tissues, whereas PEA is a chemical found naturally in the body.

It was first synthesized in the early 1970s. This research compound was patented in 1974 and attracted its first and (to date) only human study four years later. Only one animal study has been conducted over the past 50 years.

According to the human study, those who were administered PRL-8-53 were able to better recall test questions than members of the placebo group. An inquiry was made of all study subjects regarding potential side effects. Not a single instance of adverse reaction was reported. [R]

A rat study, meanwhile, showed that PRL-8-53 was able to improve avoidance learning among the study subjects. It also demonstrated that rats who were administered PRL-8-53 had improved memory better than their counterparts who took a placebo pill. [R]

PureRawz sells PRL-8-53 for laboratory research use only.


How does PRL 8-53 Work?

PRL-8-53’s exact mechanisms of action are unknown. But according to the 1978 human study mentioned above, this nootropic research compound: [R]

Potentiates Dopamine

Dopamine is a neurotransmitter that affects many important functions, such as learning, motivation, mood, sleep, movement, and more. Dopamine also plays a vital role in the formation of episodic memory, which lets you remember things such as what you had for lunch yesterday. [R]

Partially Inhibits Serotonin Production

Serotonin plays several roles in your body, such as regulating sexual behavior, sleep, body temperature, and hunger. It also influences happiness, memory, and learning. However, too much serotonin can cause conditions ranging from mild (diarrhea and shivering) to severe (fever, seizures, and death). [R]

Produces Cholinergic Response

Compounds that evoke a response from the cholinergic system act upon the neurotransmitter acetylcholine, the chief neurotransmitter of the parasympathetic nervous system. It helps the brain and body function by slowing the heart rate, contracting smooth vessels, and expanding blood vessels. [R]

Further research is needed to identify PRL-8-53’s exact research mechanism.


PRL 8-53 Research

Since being synthesized in the lab in the early 1970s, only one human study has been conducted on PRL-8-53. The number of animal studies this nootropic research compound has attracted is also the same. At the time of writing, there is no ongoing research on PRL-8-53.

PRL 8-53 and Memory

In a double-blind placebo-controlled trial, 47 healthy adults volunteered to take either a placebo or a 5mg dose of PRL-8-53. Subjects over 30 years of age, and who were administered PRL-8-53, showed a 31% increase in acquisition. Retention scores improved 108 – 152% after the drug.

Research also found that subjects who gave less than 50% of answers correct on placebo showed significant improvement with this nootropic research compound. Visual memory showed a minor improvement, but it was not statistically significant.

An inquiry was made on all subjects regarding potential side effects. Not a single instance of adverse reaction was reported.

PRL 8-53 and Verbal Retention

In the only human study to date, the effects of PRL-8-53 on the retention of verbal information were investigated.

A number of word lists were prepared, each consisting of 12 one-syllable, three- or four-letter English words. The number of words recalled, and the number of words recalled in their correct order were used as the measure of verbal retention performance.

The results showed that PRL-8-53 improved retention of verbal information to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either the visual reaction time or motor control for drug vs. placebo values.

PRL 8-53 FAQs

Where to Buy PRL-8-53 Online?

PureRawz is the best place to buy PRL-8-53 online

PureRawz is the most dependable name in the nootropic community. We ensure 100% product purity and use appropriate handling methods to ensure the product reaches your doorstep in perfect condition. A certificate of analysis will be included to let you verify that our products are lab-tested.

Is PRL-8-53 Legal?

PRL-8-53 is a research chemical with an "unscheduled" legal status in the US.

PureRawz sells PRL-8-53 for research purposes only, not for veterinary or human consumption.

What is the Molecular Weight of PRL-8-53?

Approximately 319.82578 g/mol.

Does PRL-8-53 Improve Cognitive Function?

In the only human study conducted on PRL-8-53 to date, this research compound improved memory and enhanced learning, and subsequent retention.

Anecdotal evidence links this drug to increased focus and other mental abilities, but scientific proof to support such claims is lacking.

Where to Buy PRL-8-53 for Sale

PureRawz is the best place to buy PRL-8-53 for sale.

In order to be the best research chemicals supplier, we provide reference materials with every product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.


PRL-8-53 has demonstrated the ability to improve memory and verbal retention. However, the fact that it has attracted only one human study, and one animal study, to date, necessitates further investigations into this nootropic research compound.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

12 reviews for PRL-8-53

  1. Candance Blue

    Ordering was very fast and I got my package 5 days after. Very happy with the experience here.

  2. Raymond

    Somehow this magically increased my productivity. I just love it!

  3. Fred Watson

    In my experience PRL-8-53 enhances your memory recall and also makes it easier to retain information. I can recommend this product.

  4. Jason P

    I feel a lot more motivated during the day. This is truly working

  5. P Perez

    Great product, I’m on my third bottle and still getting consistent results. 

  6. Mark Enock

    The shipping process took very long. But I got my package delivered to my door after two weeks. Thank you for helping me out!

  7. Anonymous

    This stuff gives me a youthful mind.

  8. Staurt

    I’m noticing great increases in my short term memory, I am very impressed with this liquid.

  9. Harvey S

    A good addition to my regimen.

  10. Stephen Bode

    My observations show that PRL-8-53 facilitates information retention while improving memory recall. I suggest buying this product.

  11. Emmanuel Sheridan

    This item is superb, I really felt the effect. My daily routine made easy!

  12. abegailhebie

    The quality and results are outstanding.

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