AICAR

Description

AICAR Overview

AICAR is a naturally occurring and synthetically produced compound widely used in laboratory research. It is primarily known for its ability to stimulate AMP-activated protein kinase (AMPK), a key enzyme that regulates cellular energy balance.

Chemical and Molecular Properties

PubChem CID	65110
Molecular Formula	C9H15N4O8P
Molecular Weight	338.21 g/mol
Synonyms	AICA ribonucleotide 3031-94-5 Z-nucleotide
IUPAC	[(2R,3S,4R,5R)-5-(5-amino-4-carbamoylimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
CAS	3031-94-5
Labeling	Research Use Only (RUO), not for human or animal consumption
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO)
Storage Temperature	Store at -20°C
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Mechanisms of Action

In research settings, AICAR is converted into ZMP, an analog of AMP, which activates AMP-activated protein kinase (AMPK). AMPK serves as a central regulator of cellular energy, controlling how cells generate and utilize energy from fats and sugars.

This activation allows scientists to study cellular energy pathways, metabolism, and related biochemical processes under controlled laboratory conditions.

Potential Research Applications

AICAR is widely used in laboratory investigations involving cellular metabolism and signaling pathways. Common research areas include:

• AMPK Pathway Studies: Examination of AMPK activation and downstream signaling processes in experimental systems.
• Cellular Energy Regulation: Investigation of mechanisms that control cellular energy balance under energy-depleted conditions.
• Metabolic Signaling Research: Analysis of biochemical pathways associated with cellular lipid and carbohydrate metabolism.
• Cellular Stress Response: Exploration of signaling pathways involved in cellular responses to metabolic or energetic stress.
• Inflammatory Signaling Pathways: Study of molecular signaling mechanisms involved in inflammatory responses in experimental models.

All uses are restricted to in vitro or preclinical laboratory research settings.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

References:

1. Visnjic, D., Lalic, H., Dembitz, V., Tomic, B., & Smoljo, T. (2021). AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells, 10(5), 1095. https://doi.org/10.3390/cells10051095
2. Kong, L., Zhang, H., Lu, C., Shi, K., Huang, H., Zheng, Y., Wang, Y., Wang, D., Wang, H., & Huang, W. (2021). AICAR, an AMP-Activated protein kinase activator, ameliorates acute Pancreatitis-Associated liver injury partially through NRF2-Mediated antioxidant effects and inhibition of NLRP3 inflammasome activation. Frontiers in Pharmacology, 12, 724514. https://doi.org/10.3389/fphar.2021.724514