Berberine HCl – Product Details

Berberine hydrochloride is a research drug being studied for its supposed medicinal applications. This chemical has a long history of use in Ayurveda and herbal practices for a variety of purposes.

Berberine lowers blood glucose and supports vision health, as indicated by specific studies about it. The drug could also affect the immune system. It even has the potential to promote cardiovascular health. Berberine could help to maintain healthy blood sugar levels. [R]

Berberine supplements are not safe for human consumption because these are still considered research drugs. The purported benefits of this natural plant alkaloid berberine should not be viewed as an effective medical treatment for overall health.

It cannot also be a safe addition to one’s healthy diet. Buy berberine HCl for research purposes only.

PRODUCT TYPE	POWDER
Product Name	Berberine HCL powder
Application	isoquinoline alkaloid
CAS	633-65-8
Molar Mass	371.81 g/mol
Chemical Formula	C20H18ClNO4
IUPAC Name	16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
Synonyms	Benzodioxide
Storage	Minimize open-air exposure, store in a cool dry place
Terms	Kindly make yourself aware of the scientific uses of this product, and make sure to read the Terms and Conditions before making a purchase. By completing your order and making the payment, you agree to our Terms and Conditions. Please note that the packaging of the product might be slightly different than what is shown on the website. In case you are not 100% satisfied with the product you receive, you can contact us at support@purerawz.co. We will be glad to help you as customer satisfaction is our top priority.   ATTENTION: All Purerawz products are strictly restricted to LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used on humans or animals.

What is Berberine Hydrochloride?

Berberine hydrochloride is an isoquinoline alkaloid isolated from a variety of Chinese herbs, including Coptidis rhizoma, Phellodendron chinense schneid, and Phellodendron amurense, and has a wide range of pharmacological actions.

It has anti-diabetic and anti-lipid peroxidation activity, as well as anti-atherosclerotic properties. It is also neuroprotective and helps with polycystic ovary syndrome.

Berberine hydrochloride is an antibacterial, antifungal, and anti-inflammatory drug that has been used as a gastrointestinal remedy in China for thousands of years. [R]

Berberine HCl tablets were found to have a hypotensive effect in clinical practice. However, there have been few clinical studies on the use of berberine tablets to treat hypertensive patients.

Furthermore, the clinical dosage of berberine HCl tablets is not consistent, and the molecular mechanism is still unknown. [R]

Possible Applications of Berberine HCl

Berberine HCl May Help With Weight Loss

In a 12-week study of obese people, 500 mg taken three times per day resulted in an average weight loss of 5 pounds. In addition, the participants lost 3.6% of their body fat. [R]

Another study was carried out on 37 men and women who had metabolic syndrome. The participants in this study took a type of berberine supplement three times per day for three months.

In only three months, the participants reduced their BMI from 31.5 to 27.4, or from obese to overweight. They also lost belly fat and improved a variety of health indicators. [R]

The researchers believe the weight loss is due to improved fat-regulating hormone function, such as insulin, adiponectin, and leptin. [R]

Berberine appears to inhibit fat cell growth at the molecular level as well. [R] [R]

However, more research on the weight loss effects of berberine is required.

Berberine HCl May Reduce Blood Sugar Levels

Berberine dietary supplement has been shown to impact insulin sensitivity and lower blood glucose levels in people with type 2 diabetes. In fact, its efficacy is comparable to that of the widely used diabetes medication metformin. [R]

It reduces insulin resistance, increasing the effectiveness of the blood sugar-lowering hormone insulin. It also boosts glycolysis, which aids the body in breaking down sugars within cells. It reduces sugar production in the liver, slows carbohydrate breakdown in the gut, and increases the number of beneficial bacteria in the gut. [R]

In one study of 116 diabetic patients, 1 gram of berberine per day reduced fasting blood sugar by 20%, from 7.0 to 5.6 mmol/L (126 to 101 mg/dL), or from diabetic to normal levels.

It also reduced hemoglobin A1c by 12% (a marker for long-term blood sugar levels) and improved blood lipids such as cholesterol and triglycerides. [R]

Berberine and the Digestive System

The impact of berberine HCL powder on the health of the digestive system was the subject of one review article. Recent research has demonstrated that berberine and its derivatives significantly affect GI and other biological functions.

Because of these results, berberine HCl supplements could one day be used to treat inflammatory disorders, diabetes, hyperlipidemia, diarrhea, and gastroenteritis. [R]

Same studies also show that berberine ameliorates inflammation. [R]

Berberine HCl May Improve Heart Health

Berberine HCl lowers cholesterol, LDL cholesterol, and blood triglycerides, and raises HDL cholesterol, according to a review of 11 studies. [R]

Berberine is thought to work by inhibiting an enzyme called PCSK9. This causes more LDL to be removed from the bloodstream. [R] [R]

Berberine HCL also potentially reduces blood pressure since it functions as a calcium channel blocker. [R]

Berberine ameliorates inflammation in patients with acute coronary syndrome based on another study of the chemical compound. [R]

Berberine HCl May Support Liver Health

Berberine HCl is reported to inhibit cholesterol and triglyceride synthesis in human hepatoma cell line (HepG2) cells and primary hepatocytes, and treating rat hepatoma H4IIE cells with Berberine HCl shows increased glucose consumption in a dose-dependent manner.

In vivo data from various animal models also support Berberine HCl’s beneficial role in preventing or treating NAFLD. A three-week intraperitoneal injection of BBR has been shown to alleviate hyperlipidemia and fatty liver in obese mice.

A two-week treatment with a Berberine-containing formula could slow fatty degeneration in Zucker diabetic fatty rats. BBR treatment of hyperlipidemic hamsters significantly reduces fat storage in the liver. [R]

In mice with high-fat diet (HFD)-induced fatty liver, a sixteen-week BBR supplement could alleviate hepatic steatosis and reduce liver lipid content by 14%. [R]

Berberine HCl and Bone Well-being

Due to its clear influence in stimulating osteoblast proliferation and differentiation as well as reducing the creation of osteoclasts to promote bone regeneration, berberine HCl may support healthy bones. The current research on the system mechanisms and pharmacological effects of berberine, however, was lacking. [R]

Berberine HCl may Fight Infections

Berberine has been shown to be effective against pathogenic microorganisms such as bacteria, viruses, fungi, and parasites. [R] [R] [R]

How Does Berberine HCl Work?

Based on animal trials, berberine is absorbed by the body and transported into the bloodstream following ingestion.

It binds to a variety of “molecular targets” within cells, altering their function. Berberine’s main action is to activate an enzyme inside cells called AMP-activated protein kinase (AMPK).

It can be found in brain, muscle, kidney, heart, and liver cells. This enzyme is sometimes referred to as a “metabolic master switch” and is important in metabolism regulation.

Berberine also affects other molecules within cells and may even influence which genes are activated or deactivated.

Safety and Side Effects

Because berberine has a long half-life, it must be administered numerous times daily to maintain stable blood levels in clinical subjects. It has an intensely bitter taste.

There have been complaints of cramping, diarrhea, gas, constipation, and stomach pain, which are the primary adverse effects of a berberine HCl supplement.

Frequently Asked Questions

What is the difference between berberine HCl and berberine?

A quaternary ammonium salt called berberine is found in plants like Berberis. Typically, it can be found in the bark, rhizomes, stems, and roots of plants. However, the most widely used form of berberine is berberine HCl. It is a natural berberine component in chemical form.

Is berberine HCl safe?

Although some randomized controlled trials give us promising effects of berberine HCl, it is still not a recommended food supplement. Berberine supplementation should not be treated as an effective way to improve one’s healthy lifestyle. Purchase this drug for research purposes only.

Where else can you naturally find berberine HCl?

Oregon grape contains berberine HCL, a research alkaloid with alleged antibiotic and antifungal activity.

Where can you buy berberine HCl?

Pure Rawz is the best place to buy berberine HCl. We offer several nootropics in our online store that you could use in your clinical trials.

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