Colivelin

Description

Overview of Colivelin

Colivelin is an investigational synthetic hybrid peptide created for laboratory research. It is engineered by fusing an activity–dependent neurotrophic factor (ADNF) fragment to a humanin analogue (AGA–(C8R)HNG17), resulting in a peptide designed for enhanced stability and interaction with cellular signaling pathways studied in in vitro and preclinical models. The molecule has been characterized structurally and biochemically to support research into neuronal survival mechanisms and intracellular signal transduction.

Colivelin is only provided as a research reagent for laboratory use only.

Chemical and Molecular Properties

Colivelin
PubChem CID	90477169
Molecular Formula	C119H206N32O35
Molecular Weight	2645.1 g/mol
Synonyms	Colivelin TFA Colivelin trifluoroacetate salt
IUPAC Condensed	H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH
CAS	867021–83–8
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Research Use Only (RUO)
Storage Temperature	Lyophilized: –20 °C or colder
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Various Mechanisms of Colivelin

Intracellular Signaling in Experimental Systems

STAT3–related signaling:
In controlled research settings, Colivelin has been shown to influence the signal transducer and activator of transcription 3 (STAT3) pathway, a transcription factor involved in the regulation of genes linked to cell survival and anti‑apoptotic responses. Activation of this pathway is measured through increased STAT3 phosphorylation and downstream transcriptional events in cell culture models.

Ca2+/Calmodulin–Dependent Kinase IV Pathway:
Experimental evidence indicates that the ADNF component of Colivelin engages a Ca2+–dependent calmodulin kinase cascade (e.g., CaMKIV), which is distinct from STAT3 and contributes to prosurvival signaling networks in neuronal cell models.

Molecular Interactions Studied in Research

• Neuronal survival signaling: Investigated through modulation of intracellular pathways associated with prosurvival transcription and kinase activation.
• Structural stability: Colivelin’s peptide conformation and monomeric state in buffered solutions have been characterized to support its use as a consistent research tool. 

Research Applications of Colivelin in 

Colivelin is used in preclinical and in vitro research to investigate molecular mechanisms relevant to neuronal stress responses and intracellular signaling:

• Investigating Neuroprotective Signaling
• Structural and Biochemical Characterization of Hybrid Peptides
• Mechanistic Dissection of Prosurvival Pathways
• Model Peptide for Signal Transduction Research

Why Choose Purerawz for Colivelin?

Buy Colivelin for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Colivelin is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

Chiba T., Yamada M., Hashimoto Y., et al. Development of a femtomolar‑acting humanin derivative named Colivelin by attaching activity–dependent neurotrophic factor to its N terminus: characterization of Colivelin–mediated neuroprotection against Alzheimer’s disease‑relevant insults in vitro and in vivo. Journal of Neuroscience. 25(44):10252–10261. https://pubmed.ncbi.nlm.nih.gov/16267233/

Arakawa T., Niikura T., Arisaka F., et al. Activity‑dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog. Journal of Peptide Science. 14(5):631–636. https://pubmed.ncbi.nlm.nih.gov/17994638/

Matsuoka M., Hashimoto Y., Aiso S., et al. Humanin and Colivelin: neuronal‑death‑suppressing peptides for Alzheimer’s disease and amyotrophic lateral sclerosis. CNS Drug Reviews. 12(2):113–122. https://pubmed.ncbi.nlm.nih.gov/16958985/

PubChem Compound Summary for CID–90477169.PubChem. National Center for Biotechnology Information, U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/90477169