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Dihexa – Product Information

It is a peptide that has exhibited excellent potential in anti-dementia activity in aged-rat models. This compound was initially developed by researchers at Washington State University. During its development, it demonstrated a potential high specificity and an ability to reach the brain. [R][R]

It has been found to potentially improve cognitive function in animal models of Alzheimer’s disease-like mental impairment. It has also been found to potentially increase synaptogenesis (creating new connections between brain cells) and recovery memory in multiple animal studies. [R][R]

PureRawz sells Dihexa for laboratory and research purposes only.

CAS Number 1401708-83-5
Molar Mass 504.672 g/mol
Chemical Formula C27H44N4O5
IUPAC Name 6-[(2S,3S)-2-[(2S)-2-hexanamido-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]hexanamide

What Is Dihexa?

It is a peptide derived from angiotensin IV (ANG IV). ANG IV is a metabolite of ANG, a protein that raises blood pressure by constricting your blood vessels. ANG IV-related peptides are widely recognized as pro-cognitive agents with the potential as anti-dementia therapeutics. [R]

In multiple animal studies, it has demonstrated a potential ability to improve cognitive functions, recover memory, and rescue cognitive impairment. Data from these animal models suggest Dihexa may have therapeutic potential as a treatment for Alzheimer’s disease. [R]

Research has shown it to be metabolically stable, potentially capable of crossing the blood-brain barrier, and possessing a long-circulating half-life of 12.68 days. This distinguishes it from other ANG-IV analogs, most of which cannot penetrate the blood-brain barrier.


How does Dihexa Work?

Here are the potential working mechanisms of Dihexa:


Activates hepatocyte growth factor (HGF) system

A mice study has shown that Dihexa binds with high affinity to HGF, a substance that performs various functions in the brain and body of the mice. The study further found that Dihexa’s pro-cognitive and synaptogenic effects depend on its activation of the HGF system. [R]


Increases synaptogenesis

Multiple animal studies have shown that Dihexa potentially increases the synthesis of new synapses (connections between neurons) in the brain. Its ability to induce synaptogenesis explains the pro-cognitive/anti-dementia properties of this compound. [R]


Dihexa Research

Multiple animal studies have been conducted on Dihexa. These studies have shown that it has the potential to be a therapeutic treatment for Alzheimer’s disease. In addition, it has been found to potentially enhance the acquisition, retention, and recall of learning and memory.

All the information presented in this guide is for information purposes only. Consult with licensed physicians conducting healthcare practice, or any other healthcare provider with your medical history for specific medical concerns.


Dihexa and Dementia

Research has shown that it exhibits anti-dementia activity in scopolamine and aged rat models. This ANG-IV analog has also been found to be a marker of synaptogenic activity. This is crucial because synaptic proteins play an important role in synaptic plasticity and cognitive function. [R]

During another animal study, Dihexa increased the number of neuronal cells and the expression of SYP protein in mice. This is crucial because SYP protein levels are lower in elderly individuals with dementia, meaning they are one of the major causes of Alzheimer’s disease. [R]

These data suggest that it may have therapeutic potential as a treatment of neurological diseases, such as Alzheimer’s disease, where increased synaptic connectivity may be beneficial.


Dihexa and Inflammation

It decreased the level of pro-inflammatory cytokines in an animal study involving mice. In addition, this compound increased the levels of the anti-inflammatory factor IL-1. These results were corroborated in another study in which Dihexa inhibited inflammation. [R][R]

Another animal study demonstrated how ANG IV dose-dependently suppressed inflammation in the brains of rats. The results of this study are relevant because Dihexa is an ANG IV analog, albeit one with an extended half-life and increased blood-brain barrier penetrability. [R]


Dihexa and Cognition

A mice study has demonstrated how Dihexa might potently improve cognitive function. This study has shown that it rescues cognitive impairment and recovers memory by ameliorating neuronal loss and inhibiting inflammation and glial activation. The study involved APP/PS1 mice. [R]

Another study demonstrated the impact of it on cognitive function in animal models. The study showed that when administered to APP/PS1 mice for three months, it rescued cognitive impairment. Aside from that, this compound helped the mice recover memory. [R]


Dihexa and Synaptogenesis

Synaptogenesis is a life-long process of the formation of connections (synapses) between neurons in the nervous system. It plays a vital role in learning, memory formation, and adaptation early in life. Synaptogenesis is also vital for the precision of brain circuitry. [R][R]

Multiple studies and animal models have shown that it may spur synaptogenesis. Its impact on synaptogenesis is similar to that of HGF. In fact, research indicates that it is Dihexa’s ability to activate HGF that is responsible for its synaptogenic activities. [R]


Dihexa Side Effects

Possible side effects of Dihexa include reduced attention span, irritability, and headaches. Dihexa is not FDA-approved and therefore shouldn’t be used for human consumption. It is recommended to consult with health care providers who offer pharmacy services, or health care services to know more.


Where to Buy Dihexa?

PureRawz is the best place to buy Dihexa online.

In order to be the best supplier of research peptides, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.


This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

10 reviews for Dihexa

  1. Jacob F

    You will not find a better Dihexa anywhere else. Very good product

  2. David Diaz

    I just wanted to say that this product really enhances cognitive functions. First I tried without any other nootropic, and it really works, but if you combine it with Sulbutiamine, you literally feel the difference and it kind of gives you a subtle hype.

  3. Rory

    Wow, you guys delivered my order in a timely manner. I’m impressed! Thumbs Up!

  4. Bernard Bailey

    Positive results for me.

  5. B Bell

    I have noticed an improvement in recalling names. Very happy with the results.

  6. X (verified owner)

    Might sound weird – but great for imaginative/divergent thought.

  7. Logan Hatfield

    Great product! I have never experienced mental clarity like this before.

  8. Garrett (verified owner)

    I’m thankful for Pure Raws in supplying this compound. I’m just a little disappointed that they told me they couldn’t tell me what the solution consisted of. As I need to list the ingredients in the study I’m working on.

  9. Anonymous (verified owner)

  10. adammatteo

    It’s become an essential part of my daily routine.

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