What Is Dihexa?

It is a peptide derived from angiotensin IV (ANG IV). ANG IV is a metabolite of ANG, a protein that raises blood pressure by constricting your blood vessels. ANG IV-related peptides are widely recognized as pro-cognitive agents with the potential as anti-dementia therapeutics. [R]

In multiple animal studies, it has demonstrated a potential ability to improve cognitive functions, recover memory, and rescue cognitive impairment. Data from these animal models suggest Dihexa may have therapeutic potential as a treatment for Alzheimer’s disease. [R]

Research has shown it to be metabolically stable, potentially capable of crossing the blood-brain barrier, and possessing a long-circulating half-life of 12.68 days. This distinguishes it from other ANG-IV analogs, most of which cannot penetrate the blood-brain barrier.

How does Dihexa Work?

Here are the potential working mechanisms of Dihexa:

Activates hepatocyte growth factor (HGF) system

A mice study has shown that Dihexa binds with high affinity to HGF, a substance that performs various functions in the brain and body of the mice. The study further found that Dihexa’s pro-cognitive and synaptogenic effects depend on its activation of the HGF system. [R]

Increases synaptogenesis

Multiple animal studies have shown that Dihexa potentially increases the synthesis of new synapses (connections between neurons) in the brain. Its ability to induce synaptogenesis explains the pro-cognitive/anti-dementia properties of this compound. [R]

Dihexa Research

Multiple animal studies have been conducted on Dihexa. These studies have shown that it has the potential to be a therapeutic treatment for Alzheimer’s disease. In addition, it has been found to potentially enhance the acquisition, retention, and recall of learning and memory.

All the information presented in this guide is for information purposes only. Consult with licensed physicians conducting healthcare practice, or any other healthcare provider with your medical history for specific medical concerns.

Dihexa and Dementia

Research has shown that it exhibits anti-dementia activity in scopolamine and aged rat models. This ANG-IV analog has also been found to be a marker of synaptogenic activity. This is crucial because synaptic proteins play an important role in synaptic plasticity and cognitive function. [R]

During another animal study, Dihexa increased the number of neuronal cells and the expression of SYP protein in mice. This is crucial because SYP protein levels are lower in elderly individuals with dementia, meaning they are one of the major causes of Alzheimer’s disease. [R]

These data suggest that it may have therapeutic potential as a treatment of neurological diseases, such as Alzheimer’s disease, where increased synaptic connectivity may be beneficial.

Dihexa and Inflammation

It decreased the level of pro-inflammatory cytokines in an animal study involving mice. In addition, this compound increased the levels of the anti-inflammatory factor IL-1. These results were corroborated in another study in which Dihexa inhibited inflammation. [R][R]

Another animal study demonstrated how ANG IV dose-dependently suppressed inflammation in the brains of rats. The results of this study are relevant because Dihexa is an ANG IV analog, albeit one with an extended half-life and increased blood-brain barrier penetrability. [R]

Dihexa and Cognition

A mice study has demonstrated how Dihexa might potently improve cognitive function. This study has shown that it rescues cognitive impairment and recovers memory by ameliorating neuronal loss and inhibiting inflammation and glial activation. The study involved APP/PS1 mice. [R]

Another study demonstrated the impact of it on cognitive function in animal models. The study showed that when administered to APP/PS1 mice for three months, it rescued cognitive impairment. Aside from that, this compound helped the mice recover memory. [R]

Dihexa and Synaptogenesis

Synaptogenesis is a life-long process of the formation of connections (synapses) between neurons in the nervous system. It plays a vital role in learning, memory formation, and adaptation early in life. Synaptogenesis is also vital for the precision of brain circuitry. [R][R]

Multiple studies and animal models have shown that it may spur synaptogenesis. Its impact on synaptogenesis is similar to that of HGF. In fact, research indicates that it is Dihexa’s ability to activate HGF that is responsible for its synaptogenic activities. [R]

Dihexa Side Effects

Possible side effects of Dihexa include reduced attention span, irritability, and headaches. Dihexa is not FDA-approved and therefore shouldn’t be used for human consumption. It is recommended to consult with health care providers who offer pharmacy services, or health care services to know more.

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